WormBase Tree Display for Gene: WBGene00007278

WBGene00007278 SMap: S_parent: Sequence: C03D6
  Identity: Version: 2
    Name: CGC_name: lab-1 Person_evidence: WBPerson113
      Sequence_name: C03D6.6
      Molecular_name: C03D6.6
        C03D6.6.1
        CE15580
      Other_name: CELE_C03D6.6 Accession_evidence: NDB BX284601
      Public_name: lab-1
    DB_info: Database: AceView gene 1K232
        WormQTL gene WBGene00007278
        WormFlux gene WBGene00007278
        NDB locus_tag CELE_C03D6.6
        NCBI gene 182160
        RefSeq protein NM_060165.7
        SwissProt UniProtAcc Q17604
        UniProt_GCRP UniProtAcc Q17604
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:47 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 05 Feb 2009 11:43:57 WBPerson2970 Name_change: CGC_name: lab-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lab
    Allele (18)
    Strain: WBStrain00005201
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (16)
    Structured_description: Concise_description: lab-1 encodes a protein containing a motif associated with binding, localization, and function of protein phosphatase 1 (PP1/Glc7); LAB-1 activity is required for establishment and maintenance of sister chromatid cohesion during meiosis; LAB-1 physically interacts with the protein phosphatases GSP-1 and GSP-2 and positively regulates the localization of GSP-2 to early meiotic nuclei; in addition, LAB-1 negatively regulates AIR-2 localization to early meiotic nuclei; LAB-1 localizes to condensed chromosomes in the germ line. Paper_evidence: WBPaper00032269
            WBPaper00041481
          Curator_confirmed: WBPerson1843
          Date_last_updated: 20 Nov 2012 00:00:00
      Automated_description: Enables protein phosphatase 1 binding activity. Involved in meiotic sister chromatid cohesion and regulation of protein localization to nucleus. Located in condensed chromosome and nucleus. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C03D6.6
    Corresponding_transcript: C03D6.6.1
    Other_sequence: CRC00213_1
      CR03512
      Tcir_isotig21065
      Tcir_isotig22694
    Associated_feature: WBsf649505
      WBsf649506
      WBsf220122
      WBsf220123
  Experimental_info: RNAi_result: WBRNAi00112287 Inferred_automatically: RNAi_primary
      WBRNAi00002896 Inferred_automatically: RNAi_primary
      WBRNAi00018240 Inferred_automatically: RNAi_primary
      WBRNAi00061574 Inferred_automatically: RNAi_primary
      WBRNAi00039520 Inferred_automatically: RNAi_primary
      WBRNAi00028392 Inferred_automatically: RNAi_primary
      WBRNAi00114695 Inferred_automatically: RNAi_primary
      WBRNAi00112273 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8521
      Expr1022004
      Expr1033139
      Expr1143622
      Expr2012992
      Expr2031224
    Drives_construct: WBCnstr00033864
    Construct_product: WBCnstr00005561
      WBCnstr00033864
    Antibody: WBAntibody00001491
    Microarray_results (18)
    Expression_cluster (131)
    Interaction (200)
  Map_info: Map: I Position: 3.83496 Error: 0.001373
    Positive: Positive_clone: C03D6 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (14)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene