mnp-1 encodes a protein related to the M1 family of metalloproteinases, but whose sequence indicates that it is unlikely to be catalytically active (MNP-1 lacks three of the four essential zinc-binding amino acids); during embryonic development mnp-1 activity is required, likely cell autonomously, for migration of muscle cells from their lateral positions to their final positions close to the dorsal and ventral midlines and for proper body morphology; an MNP-1::GFP reporter fusion localizes to the plasma membrane and is expressed from the 400-cell stage of embryogenesis through the early first larval stage in body-wall muscle, the Z1 and Z4 somatic gonad precursors, and cells in the dorsal anterior region that are likely to be neuronal precursors.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.