WormBase Tree Display for Gene: WBGene00007006

WBGene00007006 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C10C6
  Identity: Version: 1
    Name: CGC_name: npr-3 Person_evidence: WBPerson42
      Sequence_name: C10C6.2
      Molecular_name: C10C6.2
        C10C6.2.1
        CE08056
      Other_name: flp15-R
        CELE_C10C6.2 Accession_evidence: NDB BX284604
      Public_name: npr-3
    DB_info: Database: AceView gene 4M225
        WormQTL gene WBGene00007006
        WormFlux gene WBGene00007006
        NDB locus_tag CELE_C10C6.2
        Panther gene CAEEL|WormBase=WBGene00007006|UniProtKB=P90745
          family PTHR24240
        NCBI gene 182494
        RefSeq protein NM_069761.4
        TrEMBL UniProtAcc P90745
        UniProt_GCRP UniProtAcc P90745
    Species: Caenorhabditis elegans
    History: Version_change: 1 22 Apr 2004 16:09:48 WBPerson1971 Event: Created
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: npr
    Allele (35)
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (38)
    Paralog (22)
    Structured_description: Concise_description: C10C6.2 encodes a G-protein-coupled receptor for the FMRFamide-related peptides (FaRPs) encoded by flp-15; C10C6.2 is primarily coupled to Gi/Go proteins, since C10C6.2 signalling is blocked by pertussis toxin; because of its link to Gi/Go proteins, C10C6.2 is expected to be inhibitory Paper_evidence: WBPaper00006156
          Curator_confirmed: WBPerson567
          Date_last_updated: 09 Aug 2004 00:00:00
      Automated_description: Predicted to enable G protein-coupled photoreceptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to light stimulus; and phototransduction. Predicted to be located in membrane. Expressed in ventral cord neurons. Human ortholog(s) of this gene implicated in hypertension. Is an ortholog of human PRLHR (prolactin releasing hormone receptor). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10763 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4464)
  Molecular_info: Corresponding_CDS: C10C6.2
    Corresponding_transcript: C10C6.2.1
    Other_sequence: EX534709.1
      HGC01084_1
      JI243086.1
      EX548503.1
      HG10102
      Oden_isotig20340
      ACC10368_1
      Acan_isotig10351
    Associated_feature: WBsf718197
      WBsf997843
      WBsf997844
      WBsf997845
      WBsf1018210
      WBsf1018211
      WBsf229160
  Experimental_info: RNAi_result: WBRNAi00040290 Inferred_automatically: RNAi_primary
      WBRNAi00028772 Inferred_automatically: RNAi_primary
      WBRNAi00075423 Inferred_automatically: RNAi_primary
      WBRNAi00010590 Inferred_automatically: RNAi_primary
      WBRNAi00072930 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2766
      Expr1016827
      Expr1144363
      Expr2014423
      Expr2032664
    Drives_construct: WBCnstr00010940
      WBCnstr00034044
    Construct_product: WBCnstr00010940
      WBCnstr00034044
    Microarray_results (19)
    Expression_cluster (110)
    Interaction (63)
  Map_info: Map: IV Position: 4.98602 Error: 0.001483
    Positive: Positive_clone: C10C6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4832
        4863
        5044
    Pseudo_map_position
  Reference: WBPaper00006132
    WBPaper00006156
    WBPaper00027520
    WBPaper00038491
    WBPaper00043908
    WBPaper00049732
    WBPaper00050768
    WBPaper00055090
    WBPaper00055865
    WBPaper00065946
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene