WormBase Tree Display for Gene: WBGene00006999
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| WBGene00006999 | Evidence | Paper_evidence | WBPaper00005583 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F42G4 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | zyx-1 | Person_evidence | WBPerson57 | |||||
| Sequence_name | F42G4.3 | ||||||||
| Molecular_name (15) | |||||||||
| Other_name | CELE_F42G4.3 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | zyx-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:44 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | zyx | ||||||||
| Allele (371) | |||||||||
| Possibly_affected_by | WBVar02156836 | ||||||||
| WBVar02159005 | |||||||||
| Strain | WBStrain00002902 | ||||||||
| WBStrain00002940 | |||||||||
| WBStrain00031658 | |||||||||
| WBStrain00035659 | |||||||||
| WBStrain00036164 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (29) | |||||||||
| Ortholog (44) | |||||||||
| Structured_description | Concise_description | zyx-1 encodes a LIM domain protein and is most similar to vertebrate Zyxin; the vertebrate zyxin sub-family also includes migfilin, TRIP6 and LPP; the ZYX-1 protein is expressed in striated body wall muscle and localizes at dense bodies/Z-discs and in the nucleus; ZYX-1 physically interacts with P granule components (GLH proteins) and several dense body and M-line proteins, including DEB-1 (Vinculin) and ATN-1 (alpha-actinin), indicating that zyx-1 may play a role in anchoring actin filaments to dense bodies via its interaction with these proteins. | Paper_evidence | WBPaper00005583 | |||||
| WBPaper00042056 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 12 Mar 2013 00:00:00 | ||||||||
| Automated_description | Enables DEAD/H-box RNA helicase binding activity. Involved in maintenance of synapse structure. Acts upstream of or within with a positive effect on smooth muscle contraction. Located in M band; nucleus; and striated muscle dense body. Expressed in muscle cell and neurons. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Is an ortholog of human LPP (LIM domain containing preferred translocation partner in lipoma) and TRIP6 (thyroid hormone receptor interactor 6). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6679) | ||||
| Molecular_info | Corresponding_CDS | F42G4.3a | |||||||
| F42G4.3b | |||||||||
| F42G4.3c | |||||||||
| F42G4.3d | |||||||||
| F42G4.3e | |||||||||
| Corresponding_CDS_history | F42G4.3b:wp229 | ||||||||
| Corresponding_transcript | F42G4.3a.1 | ||||||||
| F42G4.3b.1 | |||||||||
| F42G4.3c.1 | |||||||||
| F42G4.3d.1 | |||||||||
| F42G4.3e.1 | |||||||||
| Other_sequence (102) | |||||||||
| Associated_feature (27) | |||||||||
| Transcription_factor | WBTranscriptionFactor000281 | ||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00003418 | ||||||||
| WBCnstr00003446 | |||||||||
| WBCnstr00013255 | |||||||||
| WBCnstr00017561 | |||||||||
| WBCnstr00034046 | |||||||||
| Construct_product | WBCnstr00013255 | ||||||||
| WBCnstr00017408 | |||||||||
| WBCnstr00017561 | |||||||||
| WBCnstr00020064 | |||||||||
| WBCnstr00020065 | |||||||||
| WBCnstr00020066 | |||||||||
| WBCnstr00020067 | |||||||||
| WBCnstr00020483 | |||||||||
| WBCnstr00034046 | |||||||||
| Antibody | WBAntibody00002404 | ||||||||
| WBAntibody00002405 | |||||||||
| WBAntibody00002406 | |||||||||
| Microarray_results (35) | |||||||||
| Expression_cluster (214) | |||||||||
| Interaction (74) | |||||||||
| Map_info | Map | II | Position | 13.979 | Error | 0.069963 | |||
| Positive | Positive_clone | F42G4 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4247 | |||||||
| 4770 | |||||||||
| 4980 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (27) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
