WormBase Tree Display for Gene: WBGene00006971
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WBGene00006971 | SMap | S_parent | Sequence | R13F6 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | zak | ||||||
Allele (57) | |||||||
Strain | WBStrain00051212 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (22) | |||||||
Ortholog (29) | |||||||
Paralog (11) | |||||||
Structured_description | Concise_description | zak-1 encodes a mitogen-activated protein kinase kinase kinase (MAPKKK) that is orthologous to mammalian zipper sterile-motif kinases (ZAKs); ZAK-1 is predicted to play a role in regulation of MAPK signaling cascades and large-scale RNAi experiments indicate that its activity is required for proper embryonic and larval development. | Paper_evidence | WBPaper00004403 | |||
WBPaper00005654 | |||||||
WBPaper00013126 | |||||||
WBPaper00024295 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 14 Aug 2006 00:00:00 | ||||||
Automated_description | Enables MAP kinase kinase kinase activity. Involved in stress-activated MAPK cascade. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Is an ortholog of human MAP3K20 (mitogen-activated protein kinase kinase kinase 20). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0111221 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17797) | ||
Molecular_info | Corresponding_CDS | R13F6.6a | |||||
R13F6.6b | |||||||
R13F6.6c | |||||||
Corresponding_CDS_history | R13F6.6:wp82 | ||||||
R13F6.6a:wp147 | |||||||
R13F6.6a:wp225 | |||||||
Corresponding_transcript | R13F6.6a.1 | ||||||
R13F6.6a.2 | |||||||
R13F6.6b.1 | |||||||
R13F6.6b.2 | |||||||
R13F6.6c.1 | |||||||
Other_sequence | AS11924 | ||||||
JI165508.1 | |||||||
CJC06263_1 | |||||||
MC05171 | |||||||
CR05032 | |||||||
HGC05974 | |||||||
HG09306 | |||||||
ASC04037_1 | |||||||
CRC02818_1 | |||||||
MCC05841_1 | |||||||
Experimental_info | RNAi_result (13) | ||||||
Expr_pattern | Expr1010577 | ||||||
Expr1032978 | |||||||
Expr1155575 | |||||||
Expr2018122 | |||||||
Expr2036259 | |||||||
Drives_construct | WBCnstr00034062 | ||||||
Construct_product | WBCnstr00034062 | ||||||
Microarray_results (28) | |||||||
Expression_cluster (123) | |||||||
Map_info | Map | III | Position | -0.926358 | Error | 0.00147 | |
Positive | Positive_clone | R13F6 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4762 | |||||
Pseudo_map_position | |||||||
Reference (6) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |