WormBase Tree Display for Gene: WBGene00006970
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WBGene00006970 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | F28F9 | ||||
Identity | Version | 2 | |||||
Name | CGC_name | zag-1 | Person_evidence | WBPerson110 | |||
Sequence_name | F28F9.1 | ||||||
Molecular_name | F28F9.1 | ||||||
F28F9.1.1 | |||||||
CE34546 | |||||||
Other_name | zfh-1 | Person_evidence | WBPerson1103 | ||||
CELE_F28F9.1 | Accession_evidence | NDB | BX284604 | ||||
Public_name | zag-1 | ||||||
DB_info | Database (12) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | zag | ||||||
Allele (88) | |||||||
Strain (12) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (22) | |||||||
Ortholog (36) | |||||||
Paralog | WBGene00000462 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00009553 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00018446 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | zag-1 encodes a homeodomain protein of the ZFH class which consists of a homeodomain flanked by two clusters of C2H2-type zinc fingers and is related to transcriptional repressors encoded by Drosophila zfh-1 and the vertebrate ZEB genes; ZAG-1 is required for locomotion, for neuronal differentiation, and for proper axonal branching and fasciculation; from late embryogenesis through adult stages of development, ZAG-1 is expressed dynamically in head and tail neurons and in the intestinal and anal depressor muscles. | Paper_evidence | WBPaper00006104 | |||
WBPaper00006106 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 14 Aug 2006 00:00:00 | ||||||
Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; neuron differentiation; and regulation of cell differentiation. Located in nucleus. Expressed in body wall musculature; enteric muscle; neurons; pharynx; and somatic nervous system. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Mowat-Wilson syndrome; and corneal dystrophy (multiple). Is an ortholog of human ZEB1 (zinc finger E-box binding homeobox 1) and ZEB2 (zinc finger E-box binding homeobox 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0110857 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11642) | ||
DOID:11555 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11642) | ||||
DOID:10487 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14881) | ||||
DOID:0060485 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14881) | ||||
Molecular_info | Corresponding_CDS | F28F9.1 | |||||
Corresponding_CDS_history | F28F9.1:wp88 | ||||||
F28F9.1:wp102 | |||||||
Corresponding_transcript | F28F9.1.1 | ||||||
Other_sequence (23) | |||||||
Associated_feature (26) | |||||||
Gene_product_binds (9188) | |||||||
Transcription_factor | WBTranscriptionFactor000277 | ||||||
Experimental_info | RNAi_result | WBRNAi00031537 | Inferred_automatically | RNAi_primary | |||
WBRNAi00045855 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00014064 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00115808 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00115917 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (20) | |||||||
Drives_construct (13) | |||||||
Construct_product | WBCnstr00005180 | ||||||
WBCnstr00005181 | |||||||
WBCnstr00016870 | |||||||
WBCnstr00034063 | |||||||
Microarray_results (19) | |||||||
Expression_cluster (228) | |||||||
Interaction (92) | |||||||
Product_binds_matrix | WBPmat00005565 | ||||||
WBPmat00005566 | |||||||
WBPmat00005567 | |||||||
Map_info | Map | IV | Position | -2.06697 | Error | 0.013802 | |
Positive | Positive_clone | F28F9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (30) | |||||||
Remark | Sequence connection from [Clark SG] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |