WormBase Tree Display for Gene: WBGene00006962
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| WBGene00006962 | SMap | S_parent | Sequence | C18A11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | xol-1 | Person_evidence | WBPerson421 | |||||
| Sequence_name | C18A11.5 | ||||||||
| Molecular_name | C18A11.5b | ||||||||
| C18A11.5a | |||||||||
| CE35709 | |||||||||
| C18A11.5c | |||||||||
| CE24807 | |||||||||
| C18A11.5b.1 | |||||||||
| C18A11.5c.1 | |||||||||
| Other_name | CELE_C18A11.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | xol-1 | ||||||||
| DB_info | Database | AceView | gene | XI661 | |||||
| WormQTL | gene | WBGene00006962 | |||||||
| WormFlux | gene | WBGene00006962 | |||||||
| NDB | locus_tag | CELE_C18A11.5 | |||||||
| NCBI | gene | 181061 | |||||||
| RefSeq | protein | NM_001029247.3 | |||||||
| NR_132547.1 | |||||||||
| NM_001029248.1 | |||||||||
| SwissProt | UniProtAcc | Q23229 | |||||||
| TREEFAM | TREEFAM_ID | TF343326 | |||||||
| UniProt_GCRP | UniProtAcc | Q23229 | |||||||
| RNAcentral | URSid | URS0000854D1A | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:44 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | xol | ||||||||
| Allele (57) | |||||||||
| Legacy_information | See also y9 | ||||||||
| [C.elegansII] y9 : XO animals die as embryos or small crumpled feminized L1 larvae with disorganized cellular structures; XX animals viable, apparently WT hermaphrodites. Also enhances XX pseudomale phenotype of tra-2, tra-3, her-1(gf), to fertile mating male phenotype. 35-50 kb deletion null.OA>10: y70, y95, y138 (nonsense), mn467 (XOlethal but no XX Tra enhancement), e2533, e2583 etc. Cloned: multiple transcripts (1.5, 2.2, 2.5 kb) present 10x higher in XO than XX embryo; encode novel predicted proteins with 3 different C-termini; 2.2 kb transcript necessary and sufficient for xol-1 activity.Transgene overexpression leads to XX lethality. [Miller et al. 1988; Rhind et al. 1995; TY] | |||||||||
| Strain (22) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (26) | |||||||||
| Structured_description | Concise_description | xol-1 encodes an acidic protein structurally related to members of the GHMP(galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase) family of small molecule metabolic kinases; during early development, xol-1, the master sex-determination switch gene that is a direct molecular target of the X chromosome to autosome signal, functions to specify male sexual fate and the activation state of the dosage compensation machinery (inactive in males); in XX hermaphrodites, xol-1 expression is repressed, while in males, xol-1 expression is elevated; the T-box transcription factor SEA-1 positively regulates xol-1 transcription, while the CEH-39 ONECUT homeodomain protein and SEX-1 nuclear receptor repress xol-1 transcription; two 10-bp motifs shown to be strong binding locations of two components of the dosage compensation machinery, DPY-27 and SDC-3, are found upstream of xol-1; xol-1 expression is also regulated on the posttranscriptional level by the RNA-binding protein FOX-1, which inhibits splicing of the last intron in the xol-1 pre-mRNA. | Paper_evidence | WBPaper00001077 | |||||
| WBPaper00002107 | |||||||||
| WBPaper00002827 | |||||||||
| WBPaper00003262 | |||||||||
| WBPaper00005826 | |||||||||
| WBPaper00026779 | |||||||||
| WBPaper00029117 | |||||||||
| WBPaper00030931 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 22 Oct 2007 00:00:00 | ||||||||
| Automated_description | Involved in dosage compensation by hypoactivation of X chromosome; intergenic mRNA trans splicing; and male sex determination. Predicted to be located in nucleus. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C18A11.5b | |||||||
| C18A11.5c | |||||||||
| Corresponding_CDS_history | C18A11.5:wp98 | ||||||||
| C18A11.5:wp109 | |||||||||
| C18A11.5a:wp248 | |||||||||
| Corresponding_transcript | C18A11.5a | ||||||||
| C18A11.5b.1 | |||||||||
| C18A11.5c.1 | |||||||||
| Associated_feature | WBsf1006031 | ||||||||
| WBsf1006032 | |||||||||
| WBsf1023355 | |||||||||
| WBsf236012 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00095036 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00010956 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00087455 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027629 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00040876 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1539 | ||||||||
| Expr1540 | |||||||||
| Expr13532 | |||||||||
| Expr1023035 | |||||||||
| Expr1032973 | |||||||||
| Expr1144922 | |||||||||
| Expr2018099 | |||||||||
| Expr2036237 | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product | WBCnstr00017604 | ||||||||
| WBCnstr00017605 | |||||||||
| WBCnstr00017606 | |||||||||
| WBCnstr00017607 | |||||||||
| WBCnstr00017660 | |||||||||
| WBCnstr00034067 | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (114) | |||||||||
| Interaction (141) | |||||||||
| WBProcess | WBbiopr:00000056 | ||||||||
| Map_info | Map | X | Position | -0.70195 | Error | 0.019847 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C18A11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| C37E11 | |||||||||
| Mapping_data | Multi_point (12) | ||||||||
| Pos_neg_data | 3641 | ||||||||
| 7296 | |||||||||
| 7297 | |||||||||
| 7298 | |||||||||
| 5712 | |||||||||
| 8435 | |||||||||
| 8438 | |||||||||
| 8447 | |||||||||
| Reference (174) | |||||||||
| Method | Gene |
