Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00006915

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00006915SMapS_parentSequenceCHROMOSOME_II
IdentityVersion1
NameCGC_namevha-6
Sequence_nameVW02B12L.1
Molecular_nameVW02B12L.1
VW02B12L.1.1
CE18980
Other_nameCELE_VW02B12L.1Accession_evidenceNDBBX284602
Public_namevha-6
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classvha
Allele (54)
Legacy_information[Pujol N] vha-6 is expressed only in the intestine, from the embryonic coma stage through larvae and adult
StrainWBStrain00036524
RNASeq_FPKM (74)
GO_annotation (17)
Ortholog (58)
ParalogWBGene00006768Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006914Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006916Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionvha-6 encodes an ortholog of subunit a of the membrane-bound (V0) domainof vacuolar proton-translocating ATPase (V-ATPase); VHA-6 is orthologousto human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutatedin distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated inosteopetrosis); VHA-6 is expressed in germline (P2 through Z3 cellsuntil the comma stage), on the apical surface of postembryonicintestinal cells, and at the junction between pharynx and intestine;VHA-6 is required for growth and survival past the L1 larval stage;vha-6(RNAi) animals arrest as L1 larvae and remain alive (but do notgrow) for one week; in S. cerevisiae, different V0 a-subunits (Stv1p andVph1p) direct the assembly of V-ATPases to different membranes andorganelles, suggesting that the profusion of such subunits in C. elegans(co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have asimilar function; VHA-6 is predicted to capture protons from V-ATPasetransmembrane rotor components and export the protons across themembrane.Paper_evidenceWBPaper00004601
WBPaper00004842
WBPaper00025183
WBPaper00028773
WBPaper00028774
WBPaper00028775
Curator_confirmedWBPerson567
Date_last_updated19 Nov 2006 00:00:00
Automated_descriptionPredicted to enable ATPase binding activity. Involved in nematode larval development. Located in apical plasma membrane. Part of vacuolar proton-transporting V-type ATPase complex. Expressed in Psub2; excretory cell; hypodermis; pharyngeal-intestinal valve; and uterus. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; and developmental and epileptic encephalopathy 104. Is an ortholog of several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0070390Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:865)
DOID:0110942Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11647)
DOID:14219Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:866)
DOID:0112171Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:18481)
EFO:MONDO:0015827Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:866)
DOID:0070134Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:18481)
Molecular_infoCorresponding_CDSVW02B12L.1
Corresponding_transcriptVW02B12L.1.1
Other_sequence (71)
Associated_featureWBsf650573
WBsf650574
WBsf989758
WBsf1013237
WBsf223933
Experimental_infoRNAi_result (55)
Expr_patternExpr851
Expr2404
Expr2407
Expr13465
Expr1029215
Expr1032932
Expr1158019
Expr2017992
Expr2036128
Drives_construct (205)
Construct_productWBCnstr00013297
WBCnstr00016253
WBCnstr00038389
AntibodyWBAntibody00000406
Microarray_results (20)
Expression_cluster (230)
InteractionWBInteraction000034752
WBInteraction000036295
WBInteraction000038689
WBInteraction000039152
WBInteraction000039153
WBInteraction000040241
WBInteraction000040542
WBInteraction000040618
WBInteraction000042300
WBInteraction000044264
WBInteraction000044924
WBInteraction000045477
WBInteraction000045583
WBInteraction000047135
WBInteraction000047331
WBInteraction000052689
WBInteraction000117996
WBInteraction000118133
WBInteraction000119012
WBInteraction000122021
WBInteraction000134136
WBInteraction000134138
WBInteraction000136929
WBInteraction000136930
WBInteraction000138066
WBInteraction000141408
WBInteraction000141579
WBInteraction000142249
WBInteraction000145224
WBInteraction000146843
WBInteraction000152521
WBInteraction000162125
WBInteraction000168469
WBInteraction000171761
WBInteraction000176431
WBInteraction000177060
WBInteraction000179128
WBInteraction000182015
WBInteraction000183369
WBInteraction000197313
WBInteraction000208971
WBInteraction000209433
WBInteraction000213194
WBInteraction000213874
WBInteraction000219177
WBInteraction000220131
WBInteraction000224290
WBInteraction000225015
WBInteraction000226886
WBInteraction000232000
WBInteraction000237010
WBInteraction000249278
WBInteraction000249395
WBInteraction000260037
WBInteraction000263360
WBInteraction000263492
WBInteraction000265563
WBInteraction000270198
WBInteraction000271058
WBInteraction000273261
WBInteraction000276524
WBInteraction000282586
WBInteraction000289009
WBInteraction000289986
WBInteraction000296239
WBInteraction000296363
WBInteraction000304117
WBInteraction000307263
WBInteraction000308207
WBInteraction000324435
WBInteraction000331612
WBInteraction000331613
WBInteraction000331859
WBInteraction000346589
WBInteraction000348263
WBInteraction000348801
WBInteraction000350508
WBInteraction000353533
WBInteraction000353890
WBInteraction000364594
WBInteraction000368433
WBInteraction000369788
WBInteraction000374409
WBInteraction000374785
WBInteraction000374867
WBInteraction000378842
WBInteraction000379891
WBInteraction000380118
WBInteraction000386701
WBInteraction000387488
WBInteraction000405405
WBInteraction000416300
WBInteraction000419078
WBInteraction000423798
WBInteraction000424604
WBInteraction000425119
WBInteraction000425701
WBInteraction000436424
WBInteraction000437537
WBInteraction000438069
WBInteraction000438829
WBInteraction000438932
WBInteraction000440595
WBInteraction000442760
WBInteraction000443455
WBInteraction000444385
WBInteraction000445584
WBInteraction000445870
WBInteraction000445871
WBInteraction000450897
WBInteraction000465933
WBInteraction000525298
WBInteraction000525299
WBInteraction000525300
WBInteraction000552413
WBInteraction000552903
WBInteraction000555652
WBInteraction000564400
WBInteraction000570979
WBInteraction000572706
WBInteraction000578656
WBInteraction000580496
WBInteraction000583158
Map_infoMapIIPosition3.46558Error0.000297
PositivePositive_cloneVW02B12LInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Pseudo_map_position
Reference (28)
RemarkSequence From: Pujol Nathalie via ACEDB feedback page <pujol@lgpd.univ-mrs.fr>
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene