WormBase Tree Display for Gene: WBGene00006910
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| WBGene00006910 | SMap | S_parent | Sequence | R10E11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | vha-1 | |||||||
| Sequence_name | R10E11.8 | ||||||||
| Molecular_name | R10E11.8 | ||||||||
| R10E11.8.1 | |||||||||
| CE06291 | |||||||||
| Other_name | CELE_R10E11.8 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | vha-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 29 Nov 2005 14:23:26 | WBPerson2970 | Event | Acquires_merge | WBGene00001504 | ||||
| Name_change | Other_name | fus-1 | |||||||
| 3 | 12 Jan 2006 16:38:00 | WBPerson2970 | Name_change | Other_name | fus-1 removed. Added by mistake | ||||
| Acquires_merge | WBGene00001504 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | vha | ||||||||
| Allele | WBVar00406029 | ||||||||
| WBVar01500260 | |||||||||
| WBVar00091800 | |||||||||
| WBVar01499774 | |||||||||
| WBVar00215628 | |||||||||
| WBVar01491573 | |||||||||
| WBVar00852498 | |||||||||
| WBVar00852499 | |||||||||
| WBVar00852500 | |||||||||
| Legacy_information | [Oka T, Yamamoto R, Futai M] vha for Vacuolar-type H+ ATPase. Encodes 16kD proteolipid. Upstream in operon with vha-2. vha-1::GFP strongly expressed in excretory cell, rectum and two post-anal cells. Predicted gene R10E11.8 | ||||||||
| Strain | WBStrain00035631 | ||||||||
| WBStrain00051769 | |||||||||
| WBStrain00051763 | |||||||||
| WBStrain00051767 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Contained_in_operon | CEOP3620 | ||||||||
| Ortholog (34) | |||||||||
| Paralog | WBGene00006913 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00006911 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006912 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | vha-1 encodes an ortholog of subunit c of the membrane-bound (V0) domainof vacuolar proton-translocating ATPase (V-ATPase); VHA-1 is a predictedV-ATPase transmembrane rotor component; VHA-1 and VHA-2/3 comprise aclosely related family of subunit c co-orthologs, predicted to carryprotons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32)for transmembrane export; VHA-1, like VHA-12 and VHA-17, antagonizesEFF-1-mediated cell fusion in hypodermal cells; VHA-1 is required forovulation and embryogenesis, since vha-1(RNAi) animals are sterile withpolyploid, unmatured oocytes and dead progeny; VHA-1 is required foralae formation, like the V0 subunits VHA-4 and VHA-5, but not like theV1 subunits VHA-8 or VHA-13; vha-1 shares an operon with vha-2 andR10E11.6; both vha-1 and vha-2 are expressed in the excretory cell, therectum, and a pair of cells near the anus. | Paper_evidence | WBPaper00002899 | |||||
| WBPaper00003195 | |||||||||
| WBPaper00004341 | |||||||||
| WBPaper00026591 | |||||||||
| WBPaper00027697 | |||||||||
| WBPaper00028773 | |||||||||
| WBPaper00028774 | |||||||||
| WBPaper00028775 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 19 Nov 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in several processes, including lysosomal lumen acidification; ovulation; and regulation of syncytium formation by plasma membrane fusion. Located in membrane raft. Expressed in excretory cell and rectum. Human ortholog(s) of this gene implicated in thyroid gland carcinoma. Is an ortholog of human ATP6V0C (ATPase H+ transporting V0 subunit c). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3963 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:855) | ||||
| DOID:0070472 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:855) | ||||||
| Molecular_info | Corresponding_CDS | R10E11.8 | |||||||
| Corresponding_transcript | R10E11.8.1 | ||||||||
| Other_sequence (89) | |||||||||
| Associated_feature | WBsf659449 | ||||||||
| WBsf981550 | |||||||||
| WBsf993802 | |||||||||
| WBsf1015672 | |||||||||
| WBsf225619 | |||||||||
| WBsf225620 | |||||||||
| WBsf225621 | |||||||||
| Experimental_info | RNAi_result (27) | ||||||||
| Expr_pattern | Expr1397 | ||||||||
| Expr1460 | |||||||||
| Expr9996 | |||||||||
| Expr1025127 | |||||||||
| Expr1032927 | |||||||||
| Expr1155373 | |||||||||
| Expr2017986 | |||||||||
| Expr2036122 | |||||||||
| Drives_construct | WBCnstr00008646 | ||||||||
| WBCnstr00009010 | |||||||||
| WBCnstr00010289 | |||||||||
| WBCnstr00034104 | |||||||||
| WBCnstr00038135 | |||||||||
| WBCnstr00038388 | |||||||||
| Construct_product | WBCnstr00010289 | ||||||||
| WBCnstr00034104 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (126) | |||||||||
| Interaction (45) | |||||||||
| Map_info | Map | III | Position | 1.0326 | Error | 0.005811 | |||
| Positive | Positive_clone | R10E11 | Person_evidence | WBPerson5079 | |||||
| WBPerson5074 | |||||||||
| Author_evidence | Yamamoto R | ||||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 5015 | |||||||
| Pseudo_map_position | |||||||||
| Reference (20) | |||||||||
| Remark | Data extracted from Oka et al. (1997) | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| fus-1 was mistakenly added as other_name to vha-1. It has now been correctly added to vha-17 | Curator_confirmed | WBPerson2970 | |||||||
| [140610 pad] Gene history inconsistency in this object. Missing Acquires_merge rooted tag inferred from Version_change Event data. | Curator_confirmed | WBPerson1983 | |||||||
| Method | Gene |
