| WBGene00006843 | SMap | S_parent | Sequence | CHROMOSOME_III |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-119 | Person_evidence | WBPerson261 |
| | | Sequence_name | M142.1 |
| | | Molecular_name | M142.1a |
| | | | M142.1a.1 |
| | | | CE06203 |
| | | | M142.1b |
| | | | CE43523 |
| | | | M142.1c |
| | | | CE44343 |
| | | | M142.1b.1 |
| | | | M142.1c.1 |
| | | Other_name | 3L997 | Inferred_automatically |
| | | | CELE_M142.1 | Accession_evidence | NDB | BX284603 |
| | | Public_name | unc-119 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Allele (132) |
| | Possibly_affected_by | WBVar02152819 |
| | | WBVar02153069 |
| | | WBVar02153167 |
| | | WBVar02153169 |
| | | WBVar02153170 |
| | | WBVar02153171 |
| | | WBVar02153173 |
| | | WBVar02154063 |
| | | WBVar02158600 |
| | | WBVar02158612 |
| | Legacy_information | See also e2498 |
| | | [Maduro & Pilgrim] e2498::Tc1: strong unc, almost paralyzed adults, dumpyish, tends to curl; daf-d (daf-7 suppressible), weak FITC uptake; partially Egl; similar phenotype to eDf2; eDp6. ES3 (all stages), ME0. NA4 (ed3op, ed4oc, ed9: all similar to e2498, all putative nulls). Ref. DP. |
| | | [C.elegansII] e2498::Tc1 : severe Unc, almost paralysed adults,dumpyish, tends to curl; Daf-d, partial Egl, partial Dyf. Normal muscle ultrastructure.ES3. ME0. OA3: ed3op, ed4oc, ed9 (all similar). Cloned: encodes predicted 219 aa novel protein. unc-119:GFP expressed extensively in axons. [Maduro & Pilgrim 1995] |
| | Strain (2313) |
| | RNASeq_FPKM (74) |
| | GO_annotation (22) |
| | Ortholog (38) |
| | Paralog | WBGene00003966 | Caenorhabditis elegans | From_analysis | TreeFam |
| | Structured_description | Concise_description | unc-119 encodes a novel protein that is highly conserved amongst metazoans; unc-119 activity is required for proper development of the nervous system, including axonal branching and fasciculation, and hence, for normal movement, chemosensation, and feeding; unc-119 is expressed pan-neuronally beginning in the early embryo (~60 cells) and continuing through adulthood; although the molecular function of UNC-119 is not yet known, human UNC119, which can rescue C. elegans unc-119 mutant animals, is reported to function as a receptor-associated activator of signal transduction; thus, UNC-119 may be part of a signal transduction pathway that mediates axonal patterning in response to external developmental cues. | Paper_evidence | WBPaper00002306 |
| | | | | | WBPaper00003926 |
| | | | | | WBPaper00024591 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 15 Dec 2004 00:00:00 |
| | | Automated_description | Predicted to enable lipid binding activity. Involved in several processes, including body morphogenesis; dauer larval development; and regulation of multicellular organismal process. Located in axon. Expressed in several structures, including body wall musculature; ganglia; neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in cone-rod dystrophy and immunodeficiency 13. Is an ortholog of human UNC119 (unc-119 lipid binding chaperone) and UNC119B (unc-119 lipid binding chaperone B). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0111987 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12565) |
| | | DOID:0050572 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12565) |
| Molecular_info | Corresponding_CDS | M142.1a |
| | | M142.1b |
| | | M142.1c |
| | Corresponding_transcript | M142.1a.1 |
| | | M142.1b.1 |
| | | M142.1c.1 |
| | Other_sequence (63) |
| | Associated_feature (12) |
| Experimental_info | RNAi_result (13) |
| | Expr_pattern (18) |
| | Drives_construct (109) |
| | Construct_product (41) |
| | Antibody | WBAntibody00000421 |
| | | WBAntibody00002511 |
| | | WBAntibody00002695 |
| | Microarray_results (21) |
| | Expression_cluster | WBPaper00029359_1135 |
| | | WBPaper00029359_1166 |
| | | WBPaper00029359_1197 |
| | | WBPaper00029359_1209 |
| | | WBPaper00029359_1253 |
| | | WBPaper00029359_1291 |
| | | WBPaper00029359_1320 |
| | | WBPaper00029359_1326 |
| | | WBPaper00029359_1345 |
| | | WBPaper00029359_1439 |
| | | WBPaper00029359_1458 |
| | | WBPaper00029359_1466 |
| | | WBPaper00029359_1488 |
| | | WBPaper00029359_1546 |
| | | WBPaper00029359_1549 |
| | | WBPaper00029359_1557 |
| | | WBPaper00029359_1599 |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:CEP-sheath-cells_adult_enriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_larva_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045050:csr-1(hypomorph)_upregulated |
| | | WBPaper00045420:fertilization_upregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00048690:hermaphrodite-Z1-Z4_enriched |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049134:hpk-1(pk1393)_downregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050743:elli-1(sam-3)_downregulated |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053295:lin-22(ot267)_downregulated |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059334:sacy-1(depletion)_regulated |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059378:lmn-1(Y59C)_upregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00060634:fhod-1(tm2363)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:AFD |
| | | WBPaper00061340:ASE |
| | | WBPaper00061340:ASE_parent |
| | | WBPaper00061340:ASI_parent |
| | | WBPaper00061340:AWC |
| | | WBPaper00061340:Neuroblast_ASG_AWA |
| | | WBPaper00061466:nath-10(icb99)_upregulated |
| | | WBPaper00061466:nath-10(icb102)_upregulated |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:nrde-3-tra-4_10484 |
| | | WBPaper00061651:I1_enriched |
| | | WBPaper00061651:I3_enriched |
| | | WBPaper00061651:I5_enriched |
| | | WBPaper00061651:M2_enriched |
| | | WBPaper00061651:M5_enriched |
| | | WBPaper00061651:MI_enriched |
| | | WBPaper00061651:NSM_enriched |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062325:etr-1(lq61)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062344:grh-1(overexpression)_upregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | cgc4386_cluster_6_3 |
| | | cgc4489_group_18 |
| | | WBPaper00025032:cluster_7 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00028483:Up_mes-4_vs_WT |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036286:Pattern_D |
| | | WBPaper00037695:LD_3-day |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00040184:hcf-1up_sir-2.1down_daf-2nc |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00045263:ProLongevity-mtROS_upregulated |
| | | [cgc5376]:let-60(G12V)-regulated_genes |
| | | [cgc5767]:cluster_2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(41_min) |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | Interaction (303) |
| Map_info | Map | III | Position | 5.58925 | Error | 0.00446 |
| | Well_ordered |
| | Positive | Positive_clone | C27F7 |
| | | | C44B9 |
| | | | M142 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | Y39A1 |
| | | | Y60D9 |
| | Negative | Negative_clone | K02B6 |
| | | | K11D9 |
| | | | T27G1 |
| | Mapping_data | 2_point | 4972 |
| | | | 4973 |
| | | | 4974 |
| | | Multi_point | 1715 |
| | | | 1716 |
| | | | 1717 |
| | | Pos_neg_data | 4970 |
| | | | 4971 |
| Reference (258) |
| Remark | a sequence search shows strong similarity to C27H5.1 (II): a 92 a.a. region shows 26% identity, 51% similarity to UNC-119. |
| Method | Gene |
