WormBase Tree Display for Gene: WBGene00006840
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| WBGene00006840 | SMap | S_parent | Sequence | R05D3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-116 | Person_evidence | WBPerson261 | |||||
| Sequence_name | R05D3.7 | ||||||||
| Molecular_name | R05D3.7 | ||||||||
| R05D3.7.1 | |||||||||
| CE26945 | |||||||||
| Other_name | khc-1 | ||||||||
| CELE_R05D3.7 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | unc-116 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Allele (45) | |||||||||
| Legacy_information | See also e2281, e2282 | ||||||||
| [C.elegansII] e2281::Tc5 : L1 coiler; poor backing; variable misplacement of axons, excretory canals. OA>3: e2282, e2310, pk211, rh24 (severe phenotype,high embryonic lethality at first cleavages; abnormal membrane inventories, defective endocytosis, axon guidance defects). Cloned: encodes predicted 815 aa protein, extensive similarity to kinesin heavy chain. [Patel et al. 1993; FF; NJ; UC] | |||||||||
| Strain | WBStrain00001963 | ||||||||
| WBStrain00028846 | |||||||||
| WBStrain00007476 | |||||||||
| WBStrain00023498 | |||||||||
| WBStrain00051328 | |||||||||
| WBStrain00052047 | |||||||||
| WBStrain00052059 | |||||||||
| WBStrain00052048 | |||||||||
| WBStrain00055676 | |||||||||
| WBStrain00055522 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (47) | |||||||||
| Contained_in_operon | CEOP3512 | ||||||||
| Ortholog (38) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | unc-116 encodes a kinesin-1 heavy chain ortholog; UNC-116 is predicted to function as an anterograde microtubule-based motor and its activity is required for transport and localization of synaptic vesicle components and thus for normal locomotion and larval development; in addition, unc-116 is required for normal early translocation of the meiotic spindle to the oocyte cortex, cortical positioning of the meiosis II spindle, and polar body formation; in neurons, UNC-116 retrograde displacements are regulated by PTL-1/Tau; UNC-116 physically interacts with the kinesin light chain KLC-2 to form a kinesin-1 complex in vivo; an UNC-116::GFP fusion protein is widely expressed and seen in neurons, muscle, and the pharynx; in neurons, UNC-116::GFP exhibits diffuse localization that is excluded from the nucleus and depends upon wild-type activity of KLC-2. | Paper_evidence | WBPaper00001818 | |||||
| WBPaper00024617 | |||||||||
| WBPaper00025176 | |||||||||
| WBPaper00038442 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 09 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables plus-end-directed microtubule motor activity. Involved in several processes, including establishment of organelle localization; organelle organization; and positive regulation of cell projection organization. Located in several cellular components, including neuron projection; nuclear envelope; and synapse. Part of kinesin I complex. Expressed in several structures, including AVA; body ganglion; muscle cell; tail; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 3; asbestos-related lung carcinoma; autoimmune disease (multiple); and complex cortical dysplasia with other brain malformations 2. Is an ortholog of human KIF5A (kinesin family member 5A); KIF5B (kinesin family member 5B); and KIF5C (kinesin family member 5C). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:7148 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6323) | ||||
| DOID:0090133 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6325) | ||||||
| DOID:2377 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6323) | ||||||
| DOID:127 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6325) | ||||||
| DOID:7596 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6323) | ||||||
| DOID:0110042 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6325) | ||||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6323) | ||||||
| DOID:0081379 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6323) | ||||||
| DOID:0110763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6323) | ||||||
| DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6325) | ||||||
| Molecular_info | Corresponding_CDS | R05D3.7 | |||||||
| Corresponding_transcript | R05D3.7.1 | ||||||||
| Other_sequence (66) | |||||||||
| Associated_feature | WBsf651269 | ||||||||
| WBsf667148 | |||||||||
| WBsf667149 | |||||||||
| WBsf981520 | |||||||||
| WBsf993322 | |||||||||
| WBsf1015411 | |||||||||
| WBsf227122 | |||||||||
| WBsf227123 | |||||||||
| WBsf227124 | |||||||||
| WBsf227125 | |||||||||
| Experimental_info | RNAi_result (55) | ||||||||
| Expr_pattern | Expr3209 | ||||||||
| Expr6459 | |||||||||
| Expr8662 | |||||||||
| Expr11466 | |||||||||
| Expr1019159 | |||||||||
| Expr1032899 | |||||||||
| Expr1154983 | |||||||||
| Expr2017840 | |||||||||
| Expr2035976 | |||||||||
| Drives_construct | WBCnstr00002748 | ||||||||
| WBCnstr00005937 | |||||||||
| WBCnstr00011222 | |||||||||
| Construct_product | WBCnstr00008417 | ||||||||
| WBCnstr00009775 | |||||||||
| WBCnstr00011222 | |||||||||
| WBCnstr00019039 | |||||||||
| WBCnstr00022737 | |||||||||
| Antibody | WBAntibody00001659 | ||||||||
| WBAntibody00002830 | |||||||||
| Microarray_results (15) | |||||||||
| Expression_cluster (129) | |||||||||
| Interaction (157) | |||||||||
| Map_info | Map | III | Position | -0.324405 | Error | 0.007817 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | R05D3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| ZC267 | |||||||||
| Mapping_data | 2_point | 3798 | |||||||
| 3800 | |||||||||
| 3801 | |||||||||
| 3809 | |||||||||
| Multi_point (11) | |||||||||
| Pos_neg_data | 3802 | ||||||||
| 3805 | |||||||||
| 8634 | |||||||||
| 8641 | |||||||||
| Reference (127) | |||||||||
| Method | Gene |
