WormBase Tree Display for Gene: WBGene00006815

WBGene00006815 SMap: S_parent: Sequence: W01A11
  Identity: Version: 1
    Name: CGC_name: unc-83 Person_evidence: WBPerson261
      Sequence_name: W01A11.3
      Molecular_name (11)
      Other_name: CeGrip
        CELE_W01A11.3 Accession_evidence: NDB BX284605
      Public_name: unc-83
    DB_info: Database: WormQTL gene WBGene00006815
        WormFlux gene WBGene00006815
        OMIM disease 610743
            612998
        NDB locus_tag CELE_W01A11.3
        NCBI gene 179033
        RefSeq protein NM_001392533.1
            NM_001392532.1
            NM_001083280.3
        SwissProt UniProtAcc Q23064
        TREEFAM TREEFAM_ID TF352677
        TrEMBL UniProtAcc Q0PDL1
            G8JYF1
        UniProt_GCRP UniProtAcc Q23064
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143983
    Allele (315)
    Legacy_information: e1408ts : reverse kinker as adult variably Egl; L1 moves well; variable failures in postembryonic migration of Pn nuclei into ventral cord and (some alleles) embryonic migrations of hyp-7 hypodermal nuclei; all alleles are ts for Pn defect non-ts for hyp-7 defect; unmigrated Pn nuclei mostly fail to divide; adult male phenotype variable some can mate at 25x all can mate at 15x. ES3 ME3 (15x). NA11 (n331amber ts; e1409amber ts (suppressible only for hyp-7 defect)).
      See also e1408, e1409, n159, n1216, n1217, n1218
      [C.elegansII] e1408ts : reverse kinker as adult, variably Egl; L1 moves well; variable failures in postembryonic migration of Pn nuclei into ventral cord and (some alleles) embryonic migrations of hyp-7 hypodermal nuclei; all alleles are ts for Pn defect,non-ts for hyp-7 defect; unmigrated Pn nuclei mostly fail to divide; adult male phenotype variable, some can mate at 25C, all can mate at 15C. ES3 ME3 (15C). NA11: n331amb,ts, e1409amb,ts (suppressible only for hyp-7 defect), n159, n1218 etc. [Sulston and Horvitz 1981; MH; MT]
    Strain: WBStrain00026512
      WBStrain00037609
      WBStrain00037683
      WBStrain00004325
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog (26)
    Structured_description (2)
  Disease_info: Experimental_model: DOID:11726 Homo sapiens Paper_evidence: WBPaper00040268
          Accession_evidence: OMIM 612998
          Curator_confirmed: WBPerson324
          Date_last_updated: 14 Feb 2013 00:00:00
    Disease_relevance: Studies in elegans have contributed much to the knowledge of SUN-KASH protein complexes which link components of the nucleus to the cytoplasm; KASH domain proteins in elegans are involved in nuclear positioning and migration; the family of mammalian KASH (klarsicht, ANC-1 and Syne) domain proteins include Nesprin-1/SYNE1, Nesprin-2/SYNE2, Nesprin-3/SYNE3 and Nesprin-4/SYNE4) that encode at least 12 isoforms, by alternative transcription and splicing; most KASH domain proteins do not share primary sequence homology outside of their KASH domain; mutations in SYNE1, similar to those in LMNA/Lamin, cause laminopathic diseases like Emery-Dreifuss muscular dystrophy (EDMD) and Spinocerebellar ataxia. Homo sapiens Paper_evidence: WBPaper00040268
          Accession_evidence: OMIM 612998
              610743
          Curator_confirmed: WBPerson324
          Date_last_updated: 19 Mar 2012 00:00:00
  Models_disease_in_annotation: WBDOannot00000051
  Molecular_info: Corresponding_CDS: W01A11.3a
      W01A11.3b
      W01A11.3c
    Corresponding_CDS_history: W01A11.3:wp162
    Corresponding_transcript: W01A11.3a.1
      W01A11.3b.1
      W01A11.3b.2
      W01A11.3c.1
      W01A11.3c.2
    Other_sequence (22)
    Associated_feature (57)
  Experimental_info: RNAi_result: WBRNAi00090325 Inferred_automatically: RNAi_primary
      WBRNAi00062672 Inferred_automatically: RNAi_primary
      WBRNAi00090007 Inferred_automatically: RNAi_primary
      WBRNAi00054484 Inferred_automatically: RNAi_primary
      WBRNAi00065283 Inferred_automatically: RNAi_primary
      WBRNAi00054483 Inferred_automatically: RNAi_primary
      WBRNAi00089756 Inferred_automatically: RNAi_primary
      WBRNAi00090166 Inferred_automatically: RNAi_primary
      WBRNAi00062671 Inferred_automatically: RNAi_primary
      WBRNAi00019442 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram318
      Expr1789
      Expr6810
      Expr13170
      Expr1023585
      Expr1032880
      Expr1158032
      Expr2017912
      Expr2036048
    Drives_construct: WBCnstr00002621
    Antibody: WBAntibody00000447
      WBAntibody00002169
    Microarray_results (31)
    Expression_cluster (171)
    Interaction: WBInteraction000002613
      WBInteraction000002614
      WBInteraction000003952
      WBInteraction000028748
      WBInteraction000031053
      WBInteraction000031906
      WBInteraction000126432
      WBInteraction000126692
      WBInteraction000144292
      WBInteraction000144293
      WBInteraction000161337
      WBInteraction000165173
      WBInteraction000165939
      WBInteraction000166424
      WBInteraction000182876
      WBInteraction000185264
      WBInteraction000185267
      WBInteraction000188297
      WBInteraction000202386
      WBInteraction000211593
      WBInteraction000222083
      WBInteraction000229496
      WBInteraction000233912
      WBInteraction000233921
      WBInteraction000233963
      WBInteraction000250996
      WBInteraction000252988
      WBInteraction000264341
      WBInteraction000275759
      WBInteraction000275951
      WBInteraction000287764
      WBInteraction000301647
      WBInteraction000308332
      WBInteraction000329195
      WBInteraction000336924
      WBInteraction000339263
      WBInteraction000341901
      WBInteraction000352179
      WBInteraction000355021
      WBInteraction000365229
      WBInteraction000382071
      WBInteraction000388915
      WBInteraction000390661
      WBInteraction000391999
      WBInteraction000393801
      WBInteraction000403128
      WBInteraction000404537
      WBInteraction000405253
      WBInteraction000417689
      WBInteraction000423099
      WBInteraction000424086
      WBInteraction000425123
      WBInteraction000429033
      WBInteraction000429511
      WBInteraction000429717
      WBInteraction000429922
      WBInteraction000437649
      WBInteraction000442993
      WBInteraction000453076
      WBInteraction000453645
      WBInteraction000460696
      WBInteraction000466210
      WBInteraction000473386
      WBInteraction000522807
      WBInteraction000540196
      WBInteraction000540334
      WBInteraction000543091
      WBInteraction000543126
      WBInteraction000543127
      WBInteraction000543128
      WBInteraction000543129
      WBInteraction000543130
      WBInteraction000543131
      WBInteraction000543132
      WBInteraction000543133
      WBInteraction000543134
      WBInteraction000543135
      WBInteraction000543136
      WBInteraction000543137
      WBInteraction000543138
      WBInteraction000543139
      WBInteraction000543140
      WBInteraction000543141
      WBInteraction000543142
      WBInteraction000543143
      WBInteraction000543144
      WBInteraction000543145
      WBInteraction000543146
      WBInteraction000543147
      WBInteraction000543148
      WBInteraction000543149
      WBInteraction000543150
      WBInteraction000543151
      WBInteraction000543152
      WBInteraction000543153
      WBInteraction000543154
      WBInteraction000543155
      WBInteraction000543156
      WBInteraction000543157
      WBInteraction000543158
      WBInteraction000555681
      WBInteraction000556273
      WBInteraction000556590
      WBInteraction000556591
      WBInteraction000556813
      WBInteraction000557547
      WBInteraction000557548
  Map_info: Map: V Position: -0.105154 Error: 0.00884
    Well_ordered
    Positive: Inside_rearr: nDf32
        nDf1
        nDf18
        nDf33
      Positive_clone: W01A11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 311
      Multi_point: 141
        142
        653
        657
        658
        5590
      Pos_neg_data: 843
        1735
        1748
        6813
        6814
  Reference (75)
  Method: Gene