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WormBase Tree Display for Gene: WBGene00006812

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Name Class

WBGene00006812SMapS_parentSequenceF25C8
IdentityVersion2
NameCGC_nameunc-80Person_evidenceWBPerson261
Sequence_nameF25C8.3
Molecular_name (15)
Other_nameCELE_F25C8.3Accession_evidenceNDBBX284605
Public_nameunc-80
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
213 Nov 2007 10:02:04WBPerson2970EventAcquires_mergeWBGene00009105
Acquires_mergeWBGene00009105
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00143879
Allele (316)
Legacy_informatione1272 : slightly sluggish tends to pause good movement. ES1 ME3. NA2 (e1069).
See also e1069, e1272
[C.elegansII] e1272 : slightly sluggish, tends to pause ("fainter"), good movement; hypersensitive to volatile anaesthetics.ES1 ME3. OA2: e1069, m513. [Sedensky and Meneely 1987; Morgan et al. 1991; CW]
StrainWBStrain00032777
WBStrain00040621
WBStrain00004238
WBStrain00004286
RNASeq_FPKM (74)
GO_annotation (15)
OrthologWBGene00027983Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
Inparanoid_8
WormBase-Compara
WBGene00063566Caenorhabditis remaneiFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00158228Caenorhabditis brenneriFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00122691Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00223829Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g2227Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g16091Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP21.g7029Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP21.g7952Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g20590Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g7280Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g1186Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g2252Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g9934Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g7116Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g20767Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g1938Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_03452.g18097Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-unc-80Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold630.g21785Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_04303.g32592Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_19881Caenorhabditis latensFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g07312Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g5617Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_50426200Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrV_pilon.g18189Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00244388Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00244389Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00107425Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00294580Trichuris murisFrom_analysisWormBase-Compara
WBGene00296023Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0039536Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:26582Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:2652882Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1309976Rattus norvegicusFrom_analysisEnsEMBL-Compara
OrthoInspector
PhylomeDB
Structured_descriptionConcise_descriptionunc-80 encodes a novel protein, conserved amongst C. elegans, Drosophila, and vertebrates; unc-79 functions in a pathway with unc-77 and nca-2, which encode alpha-1 subunits of voltage-insensitive cation leak channels, to regulate presynaptic activation and thus, locomotion and the response to specific volatile anesthetics; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-80::gfp reporter fusion is expressed in many sensory and all motoneurons; in the nerve ring and in dorsal and ventral nerve cords, UNC-80 localizes to specific axonal regions, but not to synapses; UNC-80, UNC-77, and UNC-79, an additional novel protein believed to act in the same pathway, reciprocally regulate their expression levels in neurons.Paper_evidenceWBPaper00001281
WBPaper00031000
WBPaper00031592
Curator_confirmedWBPerson1843
Date_last_updated22 Jun 2010 00:00:00
Automated_descriptionEnables monoatomic cation channel activity. Involved in several processes, including monoatomic cation homeostasis; positive regulation of locomotion; and response to anesthetic. Located in axon. Part of cation channel complex. Expressed in excretory canal; hermaphrodite distal tip cell; nervous system; and non-striated muscle. Is an ortholog of human UNC80 (unc-80 homolog, NALCN channel complex subunit).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelEFO:MONDO:0014176Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:26582)
Molecular_infoCorresponding_CDSF25C8.3a
F25C8.3b
F25C8.3c
F25C8.3d
F25C8.3e
Corresponding_CDS_historyF25C8.3:wp87
F25C8.3:wp109
F25C8.3a:wp182
Corresponding_transcriptF25C8.3a.1
F25C8.3b.1
F25C8.3c.1
F25C8.3d.1
F25C8.3e.1
Other_sequence (25)
Associated_featureWBsf647771
WBsf662284
WBsf662285
WBsf662286
WBsf1003660
WBsf1003661
WBsf1003662
WBsf1022024
WBsf1022025
WBsf1022026
Experimental_infoRNAi_result (12)
Expr_patternExpr4994
Expr8059
Expr8061
Expr16166
Expr1026757
Expr1032878
Expr1149400
Expr2017910
Expr2036046
Drives_constructWBCnstr00000610
WBCnstr00001622
WBCnstr00013085
WBCnstr00042790
Construct_productWBCnstr00000610
Microarray_results (26)
Expression_cluster (205)
InteractionWBInteraction000000543
WBInteraction000000545
WBInteraction000000547
WBInteraction000000549
WBInteraction000000983
WBInteraction000005397
WBInteraction000005400
WBInteraction000005404
WBInteraction000052191
WBInteraction000052197
WBInteraction000052202
WBInteraction000052207
WBInteraction000052209
WBInteraction000052325
WBInteraction000052354
WBInteraction000052774
WBInteraction000190426
WBInteraction000243097
WBInteraction000249288
WBInteraction000262143
WBInteraction000278974
WBInteraction000336034
WBInteraction000372304
WBInteraction000377672
WBInteraction000392695
WBInteraction000393773
WBInteraction000396459
WBInteraction000413751
WBInteraction000445552
WBInteraction000449697
WBInteraction000456553
WBInteraction000460418
WBInteraction000503016
WBInteraction000503017
WBInteraction000503536
WBInteraction000503537
WBInteraction000518930
WBInteraction000518931
WBInteraction000519119
WBInteraction000519121
WBInteraction000543059
Map_infoMapVPosition25.581Error0.021198
PositivePositive_cloneF25C8Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point1568
Reference (46)
MethodGene