WormBase Tree Display for Gene: WBGene00006812
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| WBGene00006812 | SMap | S_parent | Sequence | F25C8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | unc-80 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F25C8.3 | ||||||||
| Molecular_name (15) | |||||||||
| Other_name | CELE_F25C8.3 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | unc-80 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 13 Nov 2007 10:02:04 | WBPerson2970 | Event | Acquires_merge | WBGene00009105 | ||||
| Acquires_merge | WBGene00009105 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143879 | ||||||||
| Allele (316) | |||||||||
| Legacy_information | e1272 : slightly sluggish tends to pause good movement. ES1 ME3. NA2 (e1069). | ||||||||
| See also e1069, e1272 | |||||||||
| [C.elegansII] e1272 : slightly sluggish, tends to pause ("fainter"), good movement; hypersensitive to volatile anaesthetics.ES1 ME3. OA2: e1069, m513. [Sedensky and Meneely 1987; Morgan et al. 1991; CW] | |||||||||
| Strain | WBStrain00032777 | ||||||||
| WBStrain00040621 | |||||||||
| WBStrain00004238 | |||||||||
| WBStrain00004286 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (35) | |||||||||
| Structured_description | Concise_description | unc-80 encodes a novel protein, conserved amongst C. elegans, Drosophila, and vertebrates; unc-79 functions in a pathway with unc-77 and nca-2, which encode alpha-1 subunits of voltage-insensitive cation leak channels, to regulate presynaptic activation and thus, locomotion and the response to specific volatile anesthetics; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-80::gfp reporter fusion is expressed in many sensory and all motoneurons; in the nerve ring and in dorsal and ventral nerve cords, UNC-80 localizes to specific axonal regions, but not to synapses; UNC-80, UNC-77, and UNC-79, an additional novel protein believed to act in the same pathway, reciprocally regulate their expression levels in neurons. | Paper_evidence | WBPaper00001281 | |||||
| WBPaper00031000 | |||||||||
| WBPaper00031592 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 22 Jun 2010 00:00:00 | ||||||||
| Automated_description | Enables monoatomic cation channel activity. Involved in several processes, including monoatomic cation homeostasis; positive regulation of locomotion; and response to anesthetic. Located in axon. Part of cation channel complex. Expressed in excretory canal; hermaphrodite distal tip cell; nervous system; and non-striated muscle. Is an ortholog of human UNC80 (unc-80 homolog, NALCN channel complex subunit). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | EFO:MONDO:0014176 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:26582) | ||||
| Molecular_info | Corresponding_CDS | F25C8.3a | |||||||
| F25C8.3b | |||||||||
| F25C8.3c | |||||||||
| F25C8.3d | |||||||||
| F25C8.3e | |||||||||
| Corresponding_CDS_history | F25C8.3:wp87 | ||||||||
| F25C8.3:wp109 | |||||||||
| F25C8.3a:wp182 | |||||||||
| Corresponding_transcript | F25C8.3a.1 | ||||||||
| F25C8.3b.1 | |||||||||
| F25C8.3c.1 | |||||||||
| F25C8.3d.1 | |||||||||
| F25C8.3e.1 | |||||||||
| Other_sequence (25) | |||||||||
| Associated_feature | WBsf647771 | ||||||||
| WBsf662284 | |||||||||
| WBsf662285 | |||||||||
| WBsf662286 | |||||||||
| WBsf1003660 | |||||||||
| WBsf1003661 | |||||||||
| WBsf1003662 | |||||||||
| WBsf1022024 | |||||||||
| WBsf1022025 | |||||||||
| WBsf1022026 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr4994 | ||||||||
| Expr8059 | |||||||||
| Expr8061 | |||||||||
| Expr16166 | |||||||||
| Expr1026757 | |||||||||
| Expr1032878 | |||||||||
| Expr1149400 | |||||||||
| Expr2017910 | |||||||||
| Expr2036046 | |||||||||
| Drives_construct | WBCnstr00000610 | ||||||||
| WBCnstr00001622 | |||||||||
| WBCnstr00013085 | |||||||||
| WBCnstr00042790 | |||||||||
| Construct_product | WBCnstr00000610 | ||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (205) | |||||||||
| Interaction | WBInteraction000000543 | ||||||||
| WBInteraction000000545 | |||||||||
| WBInteraction000000547 | |||||||||
| WBInteraction000000549 | |||||||||
| WBInteraction000000983 | |||||||||
| WBInteraction000005397 | |||||||||
| WBInteraction000005400 | |||||||||
| WBInteraction000005404 | |||||||||
| WBInteraction000052191 | |||||||||
| WBInteraction000052197 | |||||||||
| WBInteraction000052202 | |||||||||
| WBInteraction000052207 | |||||||||
| WBInteraction000052209 | |||||||||
| WBInteraction000052325 | |||||||||
| WBInteraction000052354 | |||||||||
| WBInteraction000052774 | |||||||||
| WBInteraction000190426 | |||||||||
| WBInteraction000243097 | |||||||||
| WBInteraction000249288 | |||||||||
| WBInteraction000262143 | |||||||||
| WBInteraction000278974 | |||||||||
| WBInteraction000336034 | |||||||||
| WBInteraction000372304 | |||||||||
| WBInteraction000377672 | |||||||||
| WBInteraction000392695 | |||||||||
| WBInteraction000393773 | |||||||||
| WBInteraction000396459 | |||||||||
| WBInteraction000413751 | |||||||||
| WBInteraction000445552 | |||||||||
| WBInteraction000449697 | |||||||||
| WBInteraction000456553 | |||||||||
| WBInteraction000460418 | |||||||||
| WBInteraction000503016 | |||||||||
| WBInteraction000503017 | |||||||||
| WBInteraction000503536 | |||||||||
| WBInteraction000503537 | |||||||||
| WBInteraction000518930 | |||||||||
| WBInteraction000518931 | |||||||||
| WBInteraction000519119 | |||||||||
| WBInteraction000519121 | |||||||||
| WBInteraction000543059 | |||||||||
| Map_info | Map | V | Position | 25.581 | Error | 0.021198 | |||
| Positive | Positive_clone | F25C8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 1568 | |||||||
| Reference (46) | |||||||||
| Method | Gene |
