WormBase Tree Display for Gene: WBGene00006795
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| WBGene00006795 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y50E8A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-61 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y50E8A.4 | ||||||||
| Molecular_name | Y50E8A.4a | ||||||||
| Y50E8A.4a.1 | |||||||||
| CE47829 | |||||||||
| Y50E8A.4b | |||||||||
| CE47887 | |||||||||
| Y50E8A.4c | |||||||||
| CE47979 | |||||||||
| Y50E8A.4b.1 | |||||||||
| Y50E8A.4c.1 | |||||||||
| Other_name | Y50E8A.d | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y50E8A.4 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | unc-61 | ||||||||
| DB_info | Database | AceView | gene | 5P212 | |||||
| WormQTL | gene | WBGene00006795 | |||||||
| WormFlux | gene | WBGene00006795 | |||||||
| NDB | locus_tag | CELE_Y50E8A.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006795|UniProtKB=Q8I4C9 | |||||||
| family | PTHR18884 | ||||||||
| NCBI | gene | 179976 | |||||||
| RefSeq | protein | NM_001047733.5 | |||||||
| NM_074237.8 | |||||||||
| NM_182356.5 | |||||||||
| TREEFAM | TREEFAM_ID | TF101080 | |||||||
| TrEMBL | UniProtAcc | Q25AR8 | |||||||
| Q9U277 | |||||||||
| Q8I4C9 | |||||||||
| UniProt_GCRP | UniProtAcc | Q8I4C9 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143048 | ||||||||
| Allele (46) | |||||||||
| Legacy_information | e228 : poor backing irregular waveform in forward movement; thin; protrusive vulva; male tail very abnormal (rays absent spicules reduced etc.). ES3 ME0. NA1. | ||||||||
| [C.elegansII] e228 : poor backing irregular waveform in forward movement; thin; protrusive vulva; variable defects in neuroanatomy; male tail very abnormal (rays absent, spicules reduced etc.). ES3 ME0. NA1. [Brenner 1974; Siddiqui and Culotti 1991; SQ] | |||||||||
| Strain | WBStrain00022737 | ||||||||
| WBStrain00022738 | |||||||||
| WBStrain00022749 | |||||||||
| WBStrain00029194 | |||||||||
| WBStrain00040370 | |||||||||
| WBStrain00004131 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (55) | |||||||||
| Paralog | WBGene00006793 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00015956 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | unc-61, by alternative splicing, encodes two septin isoforms required (like the septin UNC-59) for normal axonal migration, distal tip cell migration, and postembryonic cytokinesis (at the cellular level) and for normal locomotion and formation of the postembryonic vulva, somatic gonad, and male tail (at the organismal level); both UNC-61A/B and UNC-59 are dispensable for embryonic cytokinesis and development, but are thought to be required for all postembryonic cytokinesis; UNC-61A/B and UNC-59 depend on each other for localization to the cytokinetic furrow. | Paper_evidence | WBPaper00004453 | |||||
| WBPaper00006087 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis. Located in cleavage furrow and midbody. Expressed in anterior distal tip cell; nerve ring; posterior distal tip cell; and ventral cord neurons. Human ortholog(s) of this gene implicated in Parkinson's disease. Is an ortholog of human SEPTIN11 (septin 11) and SEPTIN8 (septin 8). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:33280) | ||||
| Molecular_info | Corresponding_CDS | Y50E8A.4a | |||||||
| Y50E8A.4b | |||||||||
| Y50E8A.4c | |||||||||
| Corresponding_transcript | Y50E8A.4a.1 | ||||||||
| Y50E8A.4b.1 | |||||||||
| Y50E8A.4c.1 | |||||||||
| Other_sequence (43) | |||||||||
| Associated_feature | WBsf653409 | ||||||||
| WBsf669704 | |||||||||
| WBsf1002116 | |||||||||
| WBsf1020904 | |||||||||
| WBsf1020905 | |||||||||
| WBsf234983 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr2319 | ||||||||
| Expr2689 | |||||||||
| Expr2690 | |||||||||
| Expr1013797 | |||||||||
| Expr1032865 | |||||||||
| Expr1160551 | |||||||||
| Expr2017894 | |||||||||
| Expr2036030 | |||||||||
| Drives_construct | WBCnstr00010901 | ||||||||
| WBCnstr00034144 | |||||||||
| Construct_product | WBCnstr00010901 | ||||||||
| WBCnstr00034144 | |||||||||
| Antibody | WBAntibody00000330 | ||||||||
| WBAntibody00000931 | |||||||||
| Microarray_results (29) | |||||||||
| Expression_cluster (148) | |||||||||
| Interaction (49) | |||||||||
| Map_info | Map | V | Position | 6.74673 | Error | 0.006359 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | Y50E8A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data (3) | |||||||||
| Reference (45) | |||||||||
| Remark | Sequence connection from [Nguyen TQ, White JG] | ||||||||
| Method | Gene |
