WormBase Tree Display for Gene: WBGene00006789

WBGene00006789 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: unc-54 Person_evidence: WBPerson261
      Sequence_name: F11C3.3
      Molecular_name: F11C3.3
        F11C3.3.1
        CE09349
      Other_name: myo-4
        CELE_F11C3.3 Accession_evidence: NDB BX284601
      Public_name: unc-54
    DB_info: Database: AceView gene 1P454
        WormQTL gene WBGene00006789
        WormFlux gene WBGene00006789
        NDB locus_tag CELE_F11C3.3
        Panther gene CAEEL|WormBase=WBGene00006789|UniProtKB=P02566
          family PTHR45615
        NCBI gene 259839
        RefSeq protein NM_061195.7
        SwissProt UniProtAcc P02566
        UniProt_GCRP UniProtAcc P02566
        OMIM gene 160710
            160720
            160740
            160741
            160760
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Allele (386)
    Legacy_information: Structural gene for major body wall myosin heavy chain. Reference null allele e190 : limp paralysed phenotype at all stages larvae can move slightly more than adults Egl; muscle ultrastructure very disorganized few thick filaments. ES3 ME0. NA (recessive) > 50 including e1108amber; e1301ts; e675sd and s291 (in frame internal deletion mutants with heavy chain fragment behavioral phenotype almost paralysed slight twitcher); also Tc1 insertion mutants; etc. Also unusual suppressor alleles (NA > 15) e.g. s74 : dominant suppressor of unc-22(s12) no other dominant phenotype recessive phenotype slow stiff normal muscle ultrastructure; alteration in S1 portion of protein. Also Class 3 (dominant) alleles reference allele e1152sd : severe rigid paralysis small; e1152/+ paralysed weaker phenotype. ES3 ME0. NA (dominant) > 10 : e1153 n489 etc.; resemble e1152 or more severe recessive lethal. Intragenic revertants have Class 1 phenotypes.
      See unc-54.
      See also e569, e576, e651, e675, e843, e903, e1008, e1009, e1021, e1092, e1108, e1115, e1152, e1153, e1157, e1168, e1201, e1213, e1219, e1223, e1257, e1258, e1273, e1274, e1300, e1301, e1311, e1315, e1328, e1360, e1419, e1420, n325, n326, n327, n489, n794, r274, r308, r322, r323, r327, r360, s74, s75, s76, s77, s78, s95, s291, s409, s411
      [C.elegansII] e190 : limp paralysed phenotype at all stages; larvae can move slightly more than adults; Egl; muscle ultrastructure very disorganized few thick filaments. ES3 ME0. OA>50 (recessive): e1108amb,e1301ts, e675sd and s291 (in frame internal deletion mutants, almost paralysed slight twitchers), etc. Also unusual suppressor alleles, OA>15: s74 (dominant suppressor of unc-22(s12), recessive slow, stiff; normal muscle ultrastructure) Also dominant antimorphic alleles, OA>10:e1152sd (severe rigid paralysis, small;e1152/+ paralysed weaker phenotype. ES3 ME0),r344 (recessive lethal, r344/+ severely paralysed), etc. Intragenic revertants have recessive paralysed phenotype. Some recessive alleles (r274, e1420 etc.) are dominant antimorphs in smg background. Cloned: encodes MHC B (MYO-4), major bodywall muscle myosin heavy chain. 6 kb message,1117 aa protein. Extensive molecular analysis. [Epstein et al. 1974; McLachlan and Karn 1982;Dibb et al. 1989; Bejsovec and Anderson 1990; TR; RW]
    Strain (1380)
    RNASeq_FPKM (74)
    GO_annotation (31)
    Ortholog (82)
    Paralog (21)
    Structured_description: Concise_description: unc-54 encodes a muscle myosin class II heavy chain (MHC B); UNC-54 is the major myosin heavy chain expressed in C. elegans and is required for locomotion and egg-laying; in vivo and in vitro, UNC-54 interacts with ITR-1, an IP3 receptor, and this interaction may provide a link between calcium signaling and the muscle cytoskeleton; UNC-54 is a thick filament component that is expressed in multiple muscle cell classes including body wall, intestinal, anal depressor, and sphincter muscles as well as sex-specific muscles that develop postembryonically. Paper_evidence: WBPaper00000232
            WBPaper00000647
            WBPaper00001014
            WBPaper00005299
            WBPaper00005940
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables actin filament binding activity and microfilament motor activity. A structural constituent of muscle. Involved in several processes, including egg-laying behavior; muscle contraction; and skeletal muscle myosin thick filament assembly. Located in A band and striated muscle myosin thick filament. Part of muscle myosin complex. Expressed in anal depressor muscle; body wall musculature; head; vulval muscle; and in male. Human ortholog(s) of this gene implicated in several diseases, including congenital heart disease (multiple); distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (30)
  Molecular_info: Corresponding_CDS: F11C3.3
    Corresponding_transcript: F11C3.3.1
    Other_sequence (386)
    Associated_feature (32)
  Experimental_info: RNAi_result (12)
    Expr_pattern (15)
    Drives_construct (151)
    Construct_product: WBCnstr00011688
      WBCnstr00011704
      WBCnstr00013869
      WBCnstr00015881
      WBCnstr00018819
      WBCnstr00034149
    Antibody (11)
    Microarray_results (22)
    Expression_cluster (308)
    Interaction: WBInteraction000000047
      WBInteraction000000048
      WBInteraction000000052
      WBInteraction000000062
      WBInteraction000000092
      WBInteraction000000133
      WBInteraction000000254
      WBInteraction000000255
      WBInteraction000000256
      WBInteraction000000330
      WBInteraction000000454
      WBInteraction000000686
      WBInteraction000000748
      WBInteraction000000785
      WBInteraction000000786
      WBInteraction000000787
      WBInteraction000000917
      WBInteraction000001181
      WBInteraction000001285
      WBInteraction000001366
      WBInteraction000002476
      WBInteraction000002484
      WBInteraction000002492
      WBInteraction000002513
      WBInteraction000002859
      WBInteraction000003213
      WBInteraction000003353
      WBInteraction000005191
      WBInteraction000005192
      WBInteraction000005415
      WBInteraction000005417
      WBInteraction000005418
      WBInteraction000005419
      WBInteraction000008718
      WBInteraction000008900
      WBInteraction000009383
      WBInteraction000009808
      WBInteraction000009840
      WBInteraction000009846
      WBInteraction000009855
      WBInteraction000009862
      WBInteraction000028333
      WBInteraction000029206
      WBInteraction000029390
      WBInteraction000029640
      WBInteraction000029654
      WBInteraction000029811
      WBInteraction000031739
      WBInteraction000031741
      WBInteraction000031743
      WBInteraction000031800
      WBInteraction000031900
      WBInteraction000031901
      WBInteraction000032577
      WBInteraction000032613
      WBInteraction000032713
      WBInteraction000032717
      WBInteraction000033033
      WBInteraction000033068
      WBInteraction000033098
      WBInteraction000033204
      WBInteraction000033221
      WBInteraction000033225
      WBInteraction000033527
      WBInteraction000033528
      WBInteraction000033649
      WBInteraction000033897
      WBInteraction000034016
      WBInteraction000034120
      WBInteraction000034151
      WBInteraction000034360
      WBInteraction000034361
      WBInteraction000034409
      WBInteraction000034414
      WBInteraction000034423
      WBInteraction000034424
      WBInteraction000035125
      WBInteraction000035240
      WBInteraction000036544
      WBInteraction000041407
      WBInteraction000041994
      WBInteraction000042581
      WBInteraction000043193
      WBInteraction000043201
      WBInteraction000043210
      WBInteraction000043562
      WBInteraction000045739
      WBInteraction000046029
      WBInteraction000046686
      WBInteraction000046701
      WBInteraction000046808
      WBInteraction000046852
      WBInteraction000046955
      WBInteraction000046960
      WBInteraction000046968
      WBInteraction000046977
      WBInteraction000046978
      WBInteraction000047116
      WBInteraction000047441
      WBInteraction000047450
      WBInteraction000048580
      WBInteraction000048588
      WBInteraction000048596
      WBInteraction000049354
      WBInteraction000050000
      WBInteraction000052606
      WBInteraction000052698
      WBInteraction000118659
      WBInteraction000120438
      WBInteraction000120439
      WBInteraction000120440
      WBInteraction000120441
      WBInteraction000121872
      WBInteraction000122959
      WBInteraction000122960
      WBInteraction000122961
      WBInteraction000122962
      WBInteraction000122963
      WBInteraction000125331
      WBInteraction000126319
      WBInteraction000133786
      WBInteraction000137575
      WBInteraction000144663
      WBInteraction000147703
      WBInteraction000162558
      WBInteraction000166259
      WBInteraction000166405
      WBInteraction000166406
      WBInteraction000166407
      WBInteraction000166408
      WBInteraction000166409
      WBInteraction000166410
      WBInteraction000166431
      WBInteraction000166443
      WBInteraction000166513
      WBInteraction000174006
      WBInteraction000209621
      WBInteraction000225974
      WBInteraction000240475
      WBInteraction000240480
      WBInteraction000256762
      WBInteraction000271250
      WBInteraction000287312
      WBInteraction000290130
      WBInteraction000292081
      WBInteraction000305770
      WBInteraction000338343
      WBInteraction000352829
      WBInteraction000353868
      WBInteraction000361069
      WBInteraction000362691
      WBInteraction000371233
      WBInteraction000374944
      WBInteraction000377188
      WBInteraction000389247
      WBInteraction000393057
      WBInteraction000400154
      WBInteraction000408064
      WBInteraction000419060
      WBInteraction000444877
      WBInteraction000454195
      WBInteraction000462043
      WBInteraction000500073
      WBInteraction000500074
      WBInteraction000500075
      WBInteraction000500076
      WBInteraction000500304
      WBInteraction000500305
      WBInteraction000500306
      WBInteraction000500307
      WBInteraction000500308
      WBInteraction000502901
      WBInteraction000505018
      WBInteraction000518530
      WBInteraction000518531
      WBInteraction000518611
      WBInteraction000518885
      WBInteraction000518902
      WBInteraction000519050
      WBInteraction000519052
      WBInteraction000519062
      WBInteraction000519065
      WBInteraction000519069
      WBInteraction000519115
      WBInteraction000519151
      WBInteraction000519853
      WBInteraction000534938
      WBInteraction000536506
      WBInteraction000538533
      WBInteraction000539597
      WBInteraction000539636
      WBInteraction000539638
      WBInteraction000540636
      WBInteraction000540793
      WBInteraction000541424
      WBInteraction000541933
      WBInteraction000542398
      WBInteraction000542700
      WBInteraction000543834
      WBInteraction000549731
      WBInteraction000550042
      WBInteraction000553936
      WBInteraction000554395
      WBInteraction000554585
      WBInteraction000555391
      WBInteraction000555983
      WBInteraction000556418
      WBInteraction000559191
      WBInteraction000560387
      WBInteraction000560657
      WBInteraction000561712
      WBInteraction000562142
      WBInteraction000562327
      WBInteraction000562496
      WBInteraction000563525
      WBInteraction000564383
      WBInteraction000565225
      WBInteraction000565562
      WBInteraction000566286
      WBInteraction000566565
      WBInteraction000569211
      WBInteraction000569610
      WBInteraction000570585
      WBInteraction000571927
      WBInteraction000572532
      WBInteraction000572727
      WBInteraction000573610
      WBInteraction000580483
      WBInteraction000584594
      WBInteraction000585156
      WBInteraction000586158
    WBProcess: WBbiopr:00000040
  Map_info: Map: I Position: 27.9607 Error: 0.002243
    Well_ordered
    Positive: Inside_rearr: eDf3
        eDf10
        dxDf2
      Positive_clone: F11C3 Inferred_automatically: From sequence, transcript, pseudogene data
        SG25/36
    Mapping_data (3)
    Landmark_gene
  Reference (599)
  Remark: unc-54 posneg pcr data gives map conflict, spans deletion breakpoint ? jah 8.97
  Method: Gene