WormBase Tree Display for Gene: WBGene00006789
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| WBGene00006789 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-54 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F11C3.3 | ||||||||
| Molecular_name | F11C3.3 | ||||||||
| F11C3.3.1 | |||||||||
| CE09349 | |||||||||
| Other_name | myo-4 | ||||||||
| CELE_F11C3.3 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | unc-54 | ||||||||
| DB_info | Database | AceView | gene | 1P454 | |||||
| WormQTL | gene | WBGene00006789 | |||||||
| WormFlux | gene | WBGene00006789 | |||||||
| NDB | locus_tag | CELE_F11C3.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006789|UniProtKB=P02566 | |||||||
| family | PTHR45615 | ||||||||
| NCBI | gene | 259839 | |||||||
| RefSeq | protein | NM_061195.7 | |||||||
| SwissProt | UniProtAcc | P02566 | |||||||
| UniProt_GCRP | UniProtAcc | P02566 | |||||||
| OMIM | gene | 160710 | |||||||
| 160720 | |||||||||
| 160740 | |||||||||
| 160741 | |||||||||
| 160760 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Allele (386) | |||||||||
| Legacy_information (4) | |||||||||
| Strain (1380) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (31) | |||||||||
| Ortholog (82) | |||||||||
| Paralog (21) | |||||||||
| Structured_description | Concise_description | unc-54 encodes a muscle myosin class II heavy chain (MHC B); UNC-54 is the major myosin heavy chain expressed in C. elegans and is required for locomotion and egg-laying; in vivo and in vitro, UNC-54 interacts with ITR-1, an IP3 receptor, and this interaction may provide a link between calcium signaling and the muscle cytoskeleton; UNC-54 is a thick filament component that is expressed in multiple muscle cell classes including body wall, intestinal, anal depressor, and sphincter muscles as well as sex-specific muscles that develop postembryonically. | Paper_evidence | WBPaper00000232 | |||||
| WBPaper00000647 | |||||||||
| WBPaper00001014 | |||||||||
| WBPaper00005299 | |||||||||
| WBPaper00005940 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables actin filament binding activity and microfilament motor activity. A structural constituent of muscle. Involved in several processes, including egg-laying behavior; muscle contraction; and skeletal muscle myosin thick filament assembly. Located in A band and striated muscle myosin thick filament. Part of muscle myosin complex. Expressed in anal depressor muscle; body wall musculature; head; vulval muscle; and in male. Human ortholog(s) of this gene implicated in several diseases, including congenital heart disease (multiple); distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (30) | ||||||||
| Molecular_info | Corresponding_CDS | F11C3.3 | |||||||
| Corresponding_transcript | F11C3.3.1 | ||||||||
| Other_sequence (386) | |||||||||
| Associated_feature (32) | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern (15) | |||||||||
| Drives_construct (151) | |||||||||
| Construct_product | WBCnstr00011688 | ||||||||
| WBCnstr00011704 | |||||||||
| WBCnstr00013869 | |||||||||
| WBCnstr00015881 | |||||||||
| WBCnstr00018819 | |||||||||
| WBCnstr00034149 | |||||||||
| Antibody (11) | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (308) | |||||||||
| Interaction (231) | |||||||||
| WBProcess | WBbiopr:00000040 | ||||||||
| Map_info | Map | I | Position | 27.9607 | Error | 0.002243 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | eDf3 | |||||||
| eDf10 | |||||||||
| dxDf2 | |||||||||
| Positive_clone | F11C3 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| SG25/36 | |||||||||
| Mapping_data | 2_point (22) | ||||||||
| Multi_point (47) | |||||||||
| Pos_neg_data (20) | |||||||||
| Landmark_gene | |||||||||
| Reference (599) | |||||||||
| Remark | unc-54 posneg pcr data gives map conflict, spans deletion breakpoint ? jah 8.97 | ||||||||
| Method | Gene |
