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WormBase Tree Display for Gene: WBGene00006788

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Name Class

WBGene00006788SMapS_parentSequenceCHROMOSOME_II
IdentityVersion1
NameCGC_nameunc-53Person_evidenceWBPerson261
Sequence_nameF45E10.1
Molecular_name (24)
Other_nameCELE_F45E10.1Accession_evidenceNDBBX284602
Public_nameunc-53
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:42WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00143183
Allele (424)
Legacy_informatione404 : sluggish poor backing dumpyish somewhat Egl; males have abnormal bursal anatomy. ES2 ME0. NA4 (n152 n166 n569).
See also e2432, e2499, n152, n166, n569
[C.elegansII] e404 : sluggish, poor backing, dumpyish; somewhat Egl; multiple defects in neuronal outgrowth, branching; also defects in excretory canal extension, gonad arm growth; males have abnormal bursal anatomy. ES2 ME0. OA>5: n152, n166, n569 (synergizes with sem-5(n177) to give strong Sem migration defect),e2432, e2499, etc. Null phenotype uncertain; some lethality in strong alleles. Cloned: multiple transcripts (different 5' ends); one encodes 1528 aa protein, predicted to bind actin, ATP/GTP; may interact with SEM-5. Transgene overexpression leads to extension of growth cones along a-p axis. [Hedgecock et al. 1987; Hekimi and Kershaw 1993; UG]
StrainWBStrain00026706
WBStrain00026870
WBStrain00032757
WBStrain00034470
WBStrain00034483
WBStrain00037045
WBStrain00004162
WBStrain00004572
WBStrain00005655
RNASeq_FPKM (74)
GO_annotation (21)
Ortholog (46)
Structured_descriptionConcise_descriptionunc-53 encodes at least five large (~1200-1600 residue) proteins, orthologous to human NAV1, NAV2/RAINB1 (OMIM:607026), and NAV3, and homologous to Drosophila CG10662; UNC-53 proteins are required for anteroposterior guidance of migrating cells, axons, and excretory cell canals; unc-53 mutations affect egg laying, backward locomotion, body size, and male mating; UNC-53 proteins vary in their N-terminal regions but share common C-terminal sequences with a AAA-ATPase domain; the UNC-53 N-terminus physically interacts with ABI-1, suggesting that UNC-53 may function as a scaffold to link the ARP2/3 complex to ABI-1; UNC-53 also interacts both physically and genetically with SEM-5; unc-53 is expressed in those cells requiring it, suggesting that its function is cell-autonomous; overexpression of unc-53 induces excess cellular outgrowth.Paper_evidence (11)
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated13 Nov 2012 00:00:00
Automated_descriptionPredicted to enable actin filament binding activity. Involved in several processes, including backward locomotion; positive regulation of locomotion; and reproductive behavior. Located in cytoplasm. Expressed in several structures, including excretory cell; hermaphrodite distal tip cell; neurons; non-striated muscle; and socket cell. Is an ortholog of human NAV1 (neuron navigator 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:2559Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:15998)
Molecular_infoCorresponding_CDSF45E10.1a
F45E10.1b
F45E10.1c
F45E10.1d
F45E10.1e
F45E10.1f
F45E10.1g
F45E10.1h
Corresponding_CDS_historyF45E10.1:wp82
Corresponding_transcriptF45E10.1a.1
F45E10.1b.1
F45E10.1c.1
F45E10.1d.1
F45E10.1e.1
F45E10.1f.1
F45E10.1g.1
F45E10.1h.1
Other_sequence (27)
Associated_feature (66)
Experimental_infoRNAi_result (14)
Expr_pattern (12)
Drives_construct (25)
Construct_productWBCnstr00009444
WBCnstr00010519
WBCnstr00010520
WBCnstr00010521
WBCnstr00034150
AntibodyWBAntibody00001615
WBAntibody00001625
Microarray_results (40)
Expression_cluster (219)
InteractionWBInteraction000000132
WBInteraction000000469
WBInteraction000002728
WBInteraction000004089
WBInteraction000007193
WBInteraction000007610
WBInteraction000009541
WBInteraction000029196
WBInteraction000029222
WBInteraction000114344
WBInteraction000121277
WBInteraction000126318
WBInteraction000127598
WBInteraction000136377
WBInteraction000148735
WBInteraction000150156
WBInteraction000159589
WBInteraction000166404
WBInteraction000166470
WBInteraction000175479
WBInteraction000183674
WBInteraction000207625
WBInteraction000207626
WBInteraction000208033
WBInteraction000209538
WBInteraction000211005
WBInteraction000211452
WBInteraction000211471
WBInteraction000219245
WBInteraction000220851
WBInteraction000222907
WBInteraction000223832
WBInteraction000226581
WBInteraction000246679
WBInteraction000249007
WBInteraction000252521
WBInteraction000252970
WBInteraction000266935
WBInteraction000267338
WBInteraction000273134
WBInteraction000275437
WBInteraction000276293
WBInteraction000281482
WBInteraction000283947
WBInteraction000291605
WBInteraction000300112
WBInteraction000301995
WBInteraction000302269
WBInteraction000305065
WBInteraction000310152
WBInteraction000310491
WBInteraction000311943
WBInteraction000324531
WBInteraction000326168
WBInteraction000330965
WBInteraction000337213
WBInteraction000343513
WBInteraction000348200
WBInteraction000349681
WBInteraction000354565
WBInteraction000361016
WBInteraction000363739
WBInteraction000366429
WBInteraction000371032
WBInteraction000373218
WBInteraction000383225
WBInteraction000387983
WBInteraction000387984
WBInteraction000398871
WBInteraction000402304
WBInteraction000406256
WBInteraction000406613
WBInteraction000411972
WBInteraction000412367
WBInteraction000416836
WBInteraction000417487
WBInteraction000425180
WBInteraction000426686
WBInteraction000427618
WBInteraction000432240
WBInteraction000433790
WBInteraction000436141
WBInteraction000445409
WBInteraction000447757
WBInteraction000449531
WBInteraction000451523
WBInteraction000451831
WBInteraction000452274
WBInteraction000452743
WBInteraction000456099
WBInteraction000467762
WBInteraction000501943
WBInteraction000518887
WBInteraction000536135
WBInteraction000536136
WBInteraction000536137
WBInteraction000540983
WBInteraction000541410
WBInteraction000541503
WBInteraction000541887
WBInteraction000544737
WBInteraction000556357
WBInteraction000556425
Anatomy_functionWBbtf0113
WBbtf0114
WBbtf0118
WBbtf0119
Map_infoMapIIPosition3.16568Error0.005694
Well_ordered
PositivePositive_cloneF45E10Inferred_automaticallyFrom sequence, transcript, pseudogene data
T28D2
Mapping_data2_point43
Multi_point (11)
Pos_neg_data2145
2146
2159
2163
4533
4534
4535
4536
4539
10562
Reference (99)
MethodGene