WormBase Tree Display for Gene: WBGene00006788
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| WBGene00006788 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-53 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F45E10.1 | ||||||||
| Molecular_name (24) | |||||||||
| Other_name | CELE_F45E10.1 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | unc-53 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143183 | ||||||||
| Allele (424) | |||||||||
| Legacy_information | e404 : sluggish poor backing dumpyish somewhat Egl; males have abnormal bursal anatomy. ES2 ME0. NA4 (n152 n166 n569). | ||||||||
| See also e2432, e2499, n152, n166, n569 | |||||||||
| [C.elegansII] e404 : sluggish, poor backing, dumpyish; somewhat Egl; multiple defects in neuronal outgrowth, branching; also defects in excretory canal extension, gonad arm growth; males have abnormal bursal anatomy. ES2 ME0. OA>5: n152, n166, n569 (synergizes with sem-5(n177) to give strong Sem migration defect),e2432, e2499, etc. Null phenotype uncertain; some lethality in strong alleles. Cloned: multiple transcripts (different 5' ends); one encodes 1528 aa protein, predicted to bind actin, ATP/GTP; may interact with SEM-5. Transgene overexpression leads to extension of growth cones along a-p axis. [Hedgecock et al. 1987; Hekimi and Kershaw 1993; UG] | |||||||||
| Strain | WBStrain00026706 | ||||||||
| WBStrain00026870 | |||||||||
| WBStrain00032757 | |||||||||
| WBStrain00034470 | |||||||||
| WBStrain00034483 | |||||||||
| WBStrain00037045 | |||||||||
| WBStrain00004162 | |||||||||
| WBStrain00004572 | |||||||||
| WBStrain00005655 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (46) | |||||||||
| Structured_description | Concise_description | unc-53 encodes at least five large (~1200-1600 residue) proteins, orthologous to human NAV1, NAV2/RAINB1 (OMIM:607026), and NAV3, and homologous to Drosophila CG10662; UNC-53 proteins are required for anteroposterior guidance of migrating cells, axons, and excretory cell canals; unc-53 mutations affect egg laying, backward locomotion, body size, and male mating; UNC-53 proteins vary in their N-terminal regions but share common C-terminal sequences with a AAA-ATPase domain; the UNC-53 N-terminus physically interacts with ABI-1, suggesting that UNC-53 may function as a scaffold to link the ARP2/3 complex to ABI-1; UNC-53 also interacts both physically and genetically with SEM-5; unc-53 is expressed in those cells requiring it, suggesting that its function is cell-autonomous; overexpression of unc-53 induces excess cellular outgrowth. | Paper_evidence (11) | ||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 13 Nov 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable actin filament binding activity. Involved in several processes, including backward locomotion; positive regulation of locomotion; and reproductive behavior. Located in cytoplasm. Expressed in several structures, including excretory cell; hermaphrodite distal tip cell; neurons; non-striated muscle; and socket cell. Is an ortholog of human NAV1 (neuron navigator 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2559 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15998) | ||||
| Molecular_info | Corresponding_CDS | F45E10.1a | |||||||
| F45E10.1b | |||||||||
| F45E10.1c | |||||||||
| F45E10.1d | |||||||||
| F45E10.1e | |||||||||
| F45E10.1f | |||||||||
| F45E10.1g | |||||||||
| F45E10.1h | |||||||||
| Corresponding_CDS_history | F45E10.1:wp82 | ||||||||
| Corresponding_transcript | F45E10.1a.1 | ||||||||
| F45E10.1b.1 | |||||||||
| F45E10.1c.1 | |||||||||
| F45E10.1d.1 | |||||||||
| F45E10.1e.1 | |||||||||
| F45E10.1f.1 | |||||||||
| F45E10.1g.1 | |||||||||
| F45E10.1h.1 | |||||||||
| Other_sequence (27) | |||||||||
| Associated_feature | WBsf665273 | ||||||||
| WBsf666088 | |||||||||
| WBsf666089 | |||||||||
| WBsf666090 | |||||||||
| WBsf666091 | |||||||||
| WBsf666092 | |||||||||
| WBsf666093 | |||||||||
| WBsf666094 | |||||||||
| WBsf666095 | |||||||||
| WBsf666096 | |||||||||
| WBsf666097 | |||||||||
| WBsf666098 | |||||||||
| WBsf666099 | |||||||||
| WBsf666100 | |||||||||
| WBsf666101 | |||||||||
| WBsf666102 | |||||||||
| WBsf666103 | |||||||||
| WBsf666104 | |||||||||
| WBsf666105 | |||||||||
| WBsf666106 | |||||||||
| WBsf666107 | |||||||||
| WBsf666108 | |||||||||
| WBsf666109 | |||||||||
| WBsf666110 | |||||||||
| WBsf666111 | |||||||||
| WBsf666112 | |||||||||
| WBsf666113 | |||||||||
| WBsf666114 | |||||||||
| WBsf666115 | |||||||||
| WBsf666116 | |||||||||
| WBsf989594 | |||||||||
| WBsf989595 | |||||||||
| WBsf989596 | |||||||||
| WBsf989597 | |||||||||
| WBsf989598 | |||||||||
| WBsf989599 | |||||||||
| WBsf989600 | |||||||||
| WBsf989601 | |||||||||
| WBsf989602 | |||||||||
| WBsf989603 | |||||||||
| WBsf989604 | |||||||||
| WBsf989605 | |||||||||
| WBsf989606 | |||||||||
| WBsf989607 | |||||||||
| WBsf989608 | |||||||||
| WBsf989609 | |||||||||
| WBsf989610 | |||||||||
| WBsf989611 | |||||||||
| WBsf989612 | |||||||||
| WBsf989613 | |||||||||
| WBsf989614 | |||||||||
| WBsf989615 | |||||||||
| WBsf989616 | |||||||||
| WBsf989617 | |||||||||
| WBsf989618 | |||||||||
| WBsf1013153 | |||||||||
| WBsf1013154 | |||||||||
| WBsf1013155 | |||||||||
| WBsf1013156 | |||||||||
| WBsf1013157 | |||||||||
| WBsf1013158 | |||||||||
| WBsf1013159 | |||||||||
| WBsf1013160 | |||||||||
| WBsf1013161 | |||||||||
| WBsf1013162 | |||||||||
| WBsf223887 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct (25) | |||||||||
| Construct_product | WBCnstr00009444 | ||||||||
| WBCnstr00010519 | |||||||||
| WBCnstr00010520 | |||||||||
| WBCnstr00010521 | |||||||||
| WBCnstr00034150 | |||||||||
| Antibody | WBAntibody00001615 | ||||||||
| WBAntibody00001625 | |||||||||
| Microarray_results (40) | |||||||||
| Expression_cluster (219) | |||||||||
| Interaction (103) | |||||||||
| Anatomy_function | WBbtf0113 | ||||||||
| WBbtf0114 | |||||||||
| WBbtf0118 | |||||||||
| WBbtf0119 | |||||||||
| Map_info | Map | II | Position | 3.16568 | Error | 0.005694 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F45E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| T28D2 | |||||||||
| Mapping_data | 2_point | 43 | |||||||
| Multi_point (11) | |||||||||
| Pos_neg_data | 2145 | ||||||||
| 2146 | |||||||||
| 2159 | |||||||||
| 2163 | |||||||||
| 4533 | |||||||||
| 4534 | |||||||||
| 4535 | |||||||||
| 4536 | |||||||||
| 4539 | |||||||||
| 10562 | |||||||||
| Reference (99) | |||||||||
| Method | Gene |
