WormBase Tree Display for Gene: WBGene00006779
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| WBGene00006779 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-43 | Person_evidence | WBPerson261 | |||||
| Sequence_name | K11E8.1 | ||||||||
| Molecular_name (61) | |||||||||
| Other_name | dec-8 | ||||||||
| CELE_K11E8.1 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | unc-43 | ||||||||
| DB_info | Database (15) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143187 | ||||||||
| Allele (357) | |||||||||
| Legacy_information | e408 : slow slightly rippling movement poor backing thin; old adults Egl almost paralysed tend to shrink and relax when prodded; larvae move better. ES3 (adult) ME0. NA3 (e266 e755). | ||||||||
| Also gain-of-function allele n498sd : paralysed n498/+ less severe; revertants e.g. n498n1179 have recessive uncoordinated phenotype. | |||||||||
| See also e408, n498, n1179, n1180, n1181, n1182, n1183, n1184, n1185, n1186, n1187, n1188, n1210 | |||||||||
| [Reiner D]] Mac-m (Muscle ACtivation-Mixed) | |||||||||
| [Reiner D] n498sd is Daf-c at 27C. | |||||||||
| [Reiner D] The egg-laying phenotype of loss-of-function unc-43mutations is strong egg laying constitutive, where animals lay eggs of a very early stage. All unc-43 loss-of-function alleles confer echo defecation cycles: reiterated activation of motor program components. Furthermore, unc-43(lof) mutations have defects in locomotion motivation. The are lazy (motionless), followed by sharp jerks of the body. | |||||||||
| [C.elegansII] e408 : slow, lazy, slightly rippling movement poor backing thin; almost paralysed, tends to shrink and relax when prodded; larvae move better; Egl-c.ES3 (adult) ME1. OA>5: e266 (similar Unc, Egl-c, echo in defecation cycle; exhibits muscle activation defects in some tissues, muscle hyperactivation in others), e300 (shorter than e408, shrinking more marked), e755, sa200 (pka dec-8, weaker allele, Dec non-Unc;sa200/Df is Unc). Also gain-of-function allele: n498sd small, almost paralysed, Egl; Daf-c at 27C; n498/+ less severe). Intragenic revertants e.g. n498n1179 have recessive uncoordinated phenotype. [Park and Horvitz 1986; JT] | |||||||||
| Strain (15) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (42) | |||||||||
| Ortholog (51) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | unc-43 encodes the C. elegans ortholog of type II calcium/calmodulin-dependent protein kinase (CaMKII); unc-43 activity is required for a number of processes, including locomotion, neuronal cell fate specification and regulation of synaptic density, egg laying, defecation, and meiotic maturation; in regulating some of these processes, unc-43 acts in concert with MAPKKK and G protein signaling pathways; UNC-43 is expressed in neurons, oocytes, and gonadal sheath cells; UNC-43 can regulate the activity of the EGL-2 ether-a-go-go potassium channel with which it physically interacts. | Paper_evidence (11) | ||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 09 Feb 2011 00:00:00 | ||||||||
| Automated_description | Enables calmodulin-dependent protein kinase activity; identical protein binding activity; and transmembrane transporter binding activity. Involved in MAPK cascade; medium-term memory; and positive regulation of gene expression. Acts upstream of or within serotonin biosynthetic process. Located in axon cytoplasm. Expressed in several structures, including AWC; copulatory spicule; gonadal sheath cell; oocyte; and somatic nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; intellectual disability (multiple); and malignant astrocytoma. Is an ortholog of human CAMK2D (calcium/calmodulin dependent protein kinase II delta). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1463) | ||||
| DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1460) | ||||||
| DOID:0080230 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1461) | ||||||
| DOID:3070 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1460) | ||||||
| DOID:3069 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1463) | ||||||
| DOID:0081224 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1460) | ||||||
| DOID:0080228 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1460) | ||||||
| Molecular_info | Corresponding_CDS (18) | ||||||||
| Corresponding_CDS_history | K11E8.1a:wp52 | ||||||||
| K11E8.1a:wp191 | |||||||||
| K11E8.1b:wp52 | |||||||||
| K11E8.1c:wp52 | |||||||||
| K11E8.1c:wp229 | |||||||||
| Corresponding_transcript (25) | |||||||||
| Other_sequence (69) | |||||||||
| Associated_feature (45) | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00001323 | ||||||||
| WBCnstr00002569 | |||||||||
| WBCnstr00012386 | |||||||||
| WBCnstr00018122 | |||||||||
| WBCnstr00018123 | |||||||||
| Construct_product (16) | |||||||||
| Antibody | WBAntibody00000248 | ||||||||
| Microarray_results (140) | |||||||||
| Expression_cluster (221) | |||||||||
| Interaction (196) | |||||||||
| Anatomy_function | WBbtf0509 | ||||||||
| WBbtf0511 | |||||||||
| WBbtf0512 | |||||||||
| WBbtf0513 | |||||||||
| WBbtf1063 | |||||||||
| WBProcess | WBbiopr:00000010 | ||||||||
| WBbiopr:00000039 | |||||||||
| Map_info | Map | IV | Position | 4.57616 | Error | 0.00067 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | K11E8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 114 | |||||||
| 453 | |||||||||
| 631 | |||||||||
| Multi_point (21) | |||||||||
| Pos_neg_data (13) | |||||||||
| Landmark_gene | |||||||||
| Reference (217) | |||||||||
| Picture | WBPicture0000013079 | ||||||||
| Method | Gene |
