WormBase Tree Display for Gene: WBGene00006774
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| WBGene00006774 | SMap | S_parent | Sequence | F21F3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-38 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F21F3.5 | ||||||||
| Molecular_name | F21F3.5 | ||||||||
| F21F3.5.1 | |||||||||
| CE24908 | |||||||||
| Other_name | tmr-2 | ||||||||
| CELE_F21F3.5 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | unc-38 | ||||||||
| DB_info | Database | AceView | gene | 1F466 | |||||
| WormQTL | gene | WBGene00006774 | |||||||
| WormFlux | gene | WBGene00006774 | |||||||
| NDB | locus_tag | CELE_F21F3.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006774|UniProtKB=Q23022 | |||||||
| family | PTHR18945 | ||||||||
| NCBI | gene | 172105 | |||||||
| RefSeq | protein | NM_059071.8 | |||||||
| SwissProt | UniProtAcc | Q23022 | |||||||
| UniProt_GCRP | UniProtAcc | Q23022 | |||||||
| OMIM | gene | 100690 | |||||||
| 118503 | |||||||||
| 118504 | |||||||||
| 118507 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143072 | ||||||||
| Allele (68) | |||||||||
| Legacy_information | e264 : weak kinker sluggish slightly dumpyish sometimes Egl resistant to 1mM levamisole in body but not in head; sensitive to hypoosmotic shock. ES3 ME2. NA > 40 (e213 x20 etc.). | ||||||||
| See also e213, e229, e243, e294 | |||||||||
| [C.elegansII] e264 : weak kinker, sluggish, slightly dumpyish sometimes Egl, resistant to 1mM levamisole in body but not in head; sensitive to hypoosmotic shock. ES3 ME2. OA>40: e213, e743, x20, etc. Cloned: encodes subunit of nicotinic acetylcholine receptor. [Lewis et al. 1980; ZZ] | |||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (40) | |||||||||
| Ortholog (69) | |||||||||
| Paralog (100) | |||||||||
| Structured_description | Concise_description | unc-38 encodes a nicotinic acetylcholine receptor (nAChR) alpha subunit; UNC-38 is required for normal locomotion and egg-laying, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with ACR-2, ACR-3, UNC-29, and LEV-1, non-alpha nAChR subunits, the resulting multimer can form levamisole-gated channels; UNC-38 is expressed postsynaptically in muscles and neurons where it colocalizes with TAX-6, and with ACR-8, ACR-12, and UNC-29, respectively. | Paper_evidence | WBPaper00000031 | |||||
| WBPaper00002294 | |||||||||
| WBPaper00002860 | |||||||||
| WBPaper00003080 | |||||||||
| WBPaper00003425 | |||||||||
| WBPaper00005223 | |||||||||
| WBPaper00005594 | |||||||||
| WBPaper00026635 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 Sep 2006 00:00:00 | ||||||||
| Automated_description | Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including calcium ion import across plasma membrane; neuromuscular synaptic transmission; and regulation of multicellular organismal process. Located in neuron projection and postsynaptic membrane. Expressed in several structures, including body wall musculature; copulatory spicule; enteric muscle; oblique male muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); and lung disease (multiple). Is an ortholog of human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (17) | ||||||||
| Molecular_info | Corresponding_CDS | F21F3.5 | |||||||
| Corresponding_transcript | F21F3.5.1 | ||||||||
| Other_sequence (47) | |||||||||
| Associated_feature | WBsf649123 | ||||||||
| WBsf983531 | |||||||||
| WBsf983532 | |||||||||
| WBsf1009728 | |||||||||
| WBsf219329 | |||||||||
| WBsf219330 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct (14) | |||||||||
| Construct_product (15) | |||||||||
| Antibody | WBAntibody00001428 | ||||||||
| WBAntibody00001985 | |||||||||
| WBAntibody00002833 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (169) | |||||||||
| Interaction (32) | |||||||||
| Map_info | Map | I | Position | -0.653265 | Error | 0.013847 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | gaDp1 | |||||||
| Positive_clone | F21F3 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| ZZ#11 | |||||||||
| Mapping_data | 2_point (4) | ||||||||
| Multi_point (24) | |||||||||
| Pos_neg_data | 332 | ||||||||
| 5038 | |||||||||
| 5039 | |||||||||
| 5040 | |||||||||
| 5093 | |||||||||
| 6023 | |||||||||
| 6024 | |||||||||
| Reference (161) | |||||||||
| Method | Gene |
