WormBase Tree Display for Gene: WBGene00006773
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| WBGene00006773 | SMap | S_parent | Sequence | W02D3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-37 | Person_evidence | WBPerson261 | |||||
| Sequence_name | W02D3.9 | ||||||||
| Molecular_name | W02D3.9 | ||||||||
| W02D3.9.1 | |||||||||
| CE14434 | |||||||||
| Other_name | let-76 | ||||||||
| ESG | Accession_evidence | EMBL | AF001271 | ||||||
| AF001272 | |||||||||
| CELE_W02D3.9 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | unc-37 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143071 | ||||||||
| Allele (43) | |||||||||
| Legacy_information | e262 : weak coiler fairly active. ES2 ME1. NA1. | ||||||||
| s80 : L1 lethal. NA1. | |||||||||
| L1 lethal | |||||||||
| See also s80 | |||||||||
| [C.elegansII] e262 : weak coiler, fairly active; phenotype similar to Unc-4. ES2 ME1. OA2 (recessive): s80 (pka let-76, L1 lethal), h763 (Unc, adult sterile). Also dominant suppressors of unc-4(e2322ts):wd14, wd16, wd17, wd18 (no phenotype alone, allele-specific dominant suppressors of e2322). Intragenic revertants, e.g. wd17wd19, resembl eh763. Cloned: encodes predicted 614 aa protein with similarity to groucho-related transcription factors, 6 WD40 repeats in C-term. [Miller et al. 1993; NC] | |||||||||
| Strain (15) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (35) | |||||||||
| Contained_in_operon | CEOP1348 | ||||||||
| Ortholog (54) | |||||||||
| Structured_description | Concise_description | unc-37 encodes a transducin-like WD-repeat protein orthologous to Drosophila Groucho; unc-37 plays an essential role in embryonic and neuronal fate specification; unc-37 genetically interacts with components of the transcriptional Mediator complex. | Paper_evidence | WBPaper00002798 | |||||
| WBPaper00005042 | |||||||||
| WBPaper00005136 | |||||||||
| WBPaper00030973 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 07 May 2010 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in chemical synaptic transmission; regulation of axonogenesis; and regulation of synapse structure or activity. Located in nucleus. Expressed in several structures, including germ line; head; and tail. Is an ortholog of human TLE2 (TLE family member 2, transcriptional corepressor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | EFO:MONDO:0014769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30788) | ||||
| Molecular_info | Corresponding_CDS | W02D3.9 | |||||||
| Corresponding_transcript | W02D3.9.1 | ||||||||
| Other_sequence (80) | |||||||||
| Associated_feature | WBsf034259 | ||||||||
| WBsf649254 | |||||||||
| WBsf664356 | |||||||||
| WBsf664357 | |||||||||
| WBsf664358 | |||||||||
| WBsf983991 | |||||||||
| WBsf1009987 | |||||||||
| WBsf219629 | |||||||||
| WBsf219630 | |||||||||
| Transcription_factor | WBTranscriptionFactor000434 | ||||||||
| Experimental_info | RNAi_result (34) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00002546 | ||||||||
| WBCnstr00004371 | |||||||||
| WBCnstr00006094 | |||||||||
| WBCnstr00006107 | |||||||||
| WBCnstr00006110 | |||||||||
| WBCnstr00010892 | |||||||||
| Construct_product | WBCnstr00006110 | ||||||||
| WBCnstr00010892 | |||||||||
| Antibody | WBAntibody00000145 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (138) | |||||||||
| Interaction (324) | |||||||||
| Map_info | Map | I | Position | 1.30432 | Error | 0.000643 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | qDf16 | |||||||
| nDp1 | |||||||||
| Positive_clone | W02D3 | Person_evidence | WBPerson422 | ||||||
| WBPerson43 | |||||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | 2_point | 15 | |||||||
| 7055 | |||||||||
| Multi_point (24) | |||||||||
| Pos_neg_data (41) | |||||||||
| Reference (129) | |||||||||
| Remark | [Miller D and Barnes T] unc-37 encodes a homolog of Drosophila groucho and therefore is likely to function as a transcription cofactor protein. | ||||||||
| Method | Gene |
