WormBase Tree Display for Gene: WBGene00006730
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| WBGene00006730 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F39B2 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | uev-1 | Person_evidence | WBPerson89 | |||||
| Sequence_name | F39B2.2 | ||||||||
| Molecular_name | F39B2.2 | ||||||||
| F39B2.2.1 | |||||||||
| CE16008 | |||||||||
| Other_name | mms-2 | CGC_data_submission | |||||||
| CELE_F39B2.2 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | uev-1 | ||||||||
| DB_info | Database | AceView | gene | 1P383 | |||||
| WormQTL | gene | WBGene00006730 | |||||||
| WormFlux | gene | WBGene00006730 | |||||||
| NDB | locus_tag | CELE_F39B2.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006730|UniProtKB=O45495 | |||||||
| family | PTHR24068 | ||||||||
| NCBI | gene | 173347 | |||||||
| RefSeq | protein | NM_061177.6 | |||||||
| SwissProt | UniProtAcc | O45495 | |||||||
| TREEFAM | TREEFAM_ID | TF316971 | |||||||
| UniProt_GCRP | UniProtAcc | O45495 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | uev | ||||||||
| Allele (20) | |||||||||
| Strain | WBStrain00032660 | ||||||||
| WBStrain00037221 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Contained_in_operon | CEOP1764 | ||||||||
| Ortholog (42) | |||||||||
| Paralog (18) | |||||||||
| Structured_description | Concise_description | uev-1 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the characteristic UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; UEV-1 activity is required cell autonomously for normal trafficking of the GLR-1 glutamate receptor and consequently, for normal locomotory behavior; UEV-1 physically interacts with the UBC-13 ubiquitin conjugating enzyme that is also required for normal locomotory behavior and that is also likely involved in the DNA damage response; a uev-1::gfp reporter fusion is expressed in a wide variety of tissues including the pharynx, neurons, muscle cells, vulva, intestine, distal tip cell, and cells in the anus/tail; UEV-1 reporter fusions localize to nuclei, the cytosol, and ventral cord neurites. | Paper_evidence | WBPaper00005039 | |||||
| WBPaper00005337 | |||||||||
| WBPaper00037956 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 07 Feb 2011 00:00:00 | ||||||||
| Automated_description | Enables ubiquitin conjugating enzyme binding activity. Involved in regulation of locomotion involved in locomotory behavior and regulation of protein localization to cell surface. Located in cytosol; neuron projection; and nucleus. Expressed in several structures, including anus; distal tip cell; germ line; neurons; and ventral nerve cord. Is an ortholog of human UBE2V2 (ubiquitin conjugating enzyme E2 V2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F39B2.2 | |||||||
| Corresponding_transcript | F39B2.2.1 | ||||||||
| Other_sequence (59) | |||||||||
| Associated_feature | WBsf643859 | ||||||||
| WBsf657109 | |||||||||
| WBsf986228 | |||||||||
| WBsf218828 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00116884 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00003632 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00046755 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076399 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082831 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9183 | ||||||||
| Expr9184 | |||||||||
| Expr9707 | |||||||||
| Expr1010234 | |||||||||
| Expr1032806 | |||||||||
| Expr1150629 | |||||||||
| Expr2017742 | |||||||||
| Expr2035881 | |||||||||
| Drives_construct | WBCnstr00013774 | ||||||||
| Construct_product | WBCnstr00013774 | ||||||||
| WBCnstr00013775 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (117) | |||||||||
| Interaction (93) | |||||||||
| Map_info | Map | I | Position | 26.8835 | Error | 0.138356 | |||
| Positive | Positive_clone | F39B2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4669 | |||||||
| Pseudo_map_position | |||||||||
| Reference (16) | |||||||||
| Remark | Sequence connection from [Jones D, Crowe E, Stevens TA, Candido EPM], 02/06/10 krb | ||||||||
| Sequence connection from [Boulton S, Vidal M] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
