WormBase Tree Display for Gene: WBGene00006612

WBGene00006612 SMap: S_parent: Sequence: F45G2
  Identity: Version: 1
    Name: CGC_name: trf-1 Person_evidence: WBPerson1122
      Sequence_name: F45G2.6
      Molecular_name: F45G2.6
        F45G2.6.1
        CE37519
      Other_name: CELE_F45G2.6 Accession_evidence: NDB BX284603
      Public_name: trf-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: trf
    Allele (58)
    Strain: WBStrain00029110
      WBStrain00037405
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (48)
    Paralog: WBGene00022454 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: trf-1 encodes the sole C. elegans ortholog of the Tumor Necrosis Factor (TNF) receptor-associated factor adaptor protein; from N- to C-terminus, TRF-1 has five domains: a RING finger domain, three cysteine-rich (CART) domains and a meprin-associated Traf homology (MATH) domain; trf-1(nr2014) mutant animals display a shortened lifespan and a diminished immune response to Salmonella enterica infection. Paper_evidence: WBPaper00004589
            WBPaper00004692
            WBPaper00031161
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 18 Jul 2014 00:00:00
      Automated_description: Predicted to enable zinc ion binding activity. Involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be located in cytoplasm. Expressed in CEMDL; CEMDR; CEMVL; CEMVR; and tail. Human ortholog(s) of this gene implicated in brain disease and lung adenocarcinoma. Is an ortholog of human TRAF4 (TNF receptor associated factor 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3910 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12034)
      DOID:936 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12033)
  Molecular_info: Corresponding_CDS: F45G2.6
    Corresponding_CDS_history: F45G2.6:wp132
    Corresponding_transcript: F45G2.6.1
    Associated_feature: WBsf994891
      WBsf226009
  Experimental_info: RNAi_result: WBRNAi00095281 Inferred_automatically: RNAi_primary
      WBRNAi00047439 Inferred_automatically: RNAi_primary
      WBRNAi00032324 Inferred_automatically: RNAi_primary
      WBRNAi00006284 Inferred_automatically: RNAi_primary
      WBRNAi00076434 Inferred_automatically: RNAi_primary
      WBRNAi00094757 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr14564
      Expr16439
      Expr1014051
      Expr1151280
      Expr2017493
      Expr2035632
    Drives_construct: WBCnstr00034268
      WBCnstr00041164
      WBCnstr00043020
    Construct_product: WBCnstr00034268
    Microarray_results (19)
    Expression_cluster (58)
    Interaction (58)
    WBProcess: WBbiopr:00000039
  Map_info: Map: III Position: 21.2151 Error: 0.000524
    Positive: Positive_clone: F45G2 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4242
        4739
    Pseudo_map_position
  Reference (19)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene