WormBase Tree Display for Gene: WBGene00006606
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| WBGene00006606 | SMap | S_parent | Sequence | LLC1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | tra-3 | Person_evidence | WBPerson261 | |||||
| Sequence_name | LLC1.1 | ||||||||
| Molecular_name | LLC1.1a | ||||||||
| LLC1.1a.1 | |||||||||
| CE16260 | |||||||||
| LLC1.1b | |||||||||
| Other_name | clp-5 | ||||||||
| CELE_LLC1.1 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | tra-3 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tra | ||||||||
| Reference_allele | WBVar00143747 | ||||||||
| Allele (125) | |||||||||
| Legacy_information | e1107amber mat : e1107 daughters of e1107/+ parents are wildtype hermaphrodite e1107 XX progeny of e1107 parents are abnormal sterile males or intersexes occasionally self-fertile especially at 15x (15x brood 1% of wildtype); XO phenotype wildtype. ES3 (progeny testing) ME0 (XX) ME3 (XO). NA4 (e1525amber e1767(non-amber) etc : all alleles resemble e1107). Amber alleles very efficiently suppressed. | ||||||||
| See also e2028, e2333 | |||||||||
| [C.elegansII] e1107amb,mat : XX progeny of homozygous parents are abnormal sterile males or intersexes, occasionally self-fertile, especially at 15C (15C brood 1% of wildtype); XO phenotype wildtype. Either maternal or zygotic expression of tra-3(+) sufficient for normal XX hermaphrodite development. ES3 (progeny testing) ME0 (XX) ME3 (XO). OA>5: e1525amb, e1767(non-amb), y240 etc.(resemble e1107, probable nulls), bn75ts (Mog 25C),e2333 (XX anatomically WT, brood size increased). Amber alleles very efficiently suppressed;used for sup-7 transgene selection. Cloned: encodes predicted protein with similarity to vertebrate protease calpain, but lacking calcium-binding domains. [Hodgkin 1986; Fire 1986; Hodgkin and Barnes 1991; CB] | |||||||||
| Strain (18) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (47) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | tra-3 encodes an atypical calpain regulatory protease that lacks calcium-binding EF hand domains; during development, TRA-3 likely promotes female development in XX hermaphrodites by cleaving the membrane-associated TRA-2A protein to generate a TRA-2 peptide likely to have feminizing activity; in addition, TRA-3 is one of several proteases that mediate necrotic cell death during neurodegeneration. | Paper_evidence | WBPaper00002548 | |||||
| WBPaper00004113 | |||||||||
| WBPaper00005513 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 09 Apr 2007 00:00:00 | ||||||||
| Automated_description | Enables cysteine-type endopeptidase activity. Involved in proteolysis and sex determination. Predicted to be located in cytoplasm. Expressed in several structures, including excretory cell; hypodermis; intestine; ventral nerve cord; and vulva. Human ortholog(s) of this gene implicated in neovascular inflammatory vitreoretinopathy. Is an ortholog of human CAPN5 (calpain 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9719 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1482) | ||||
| Molecular_info | Corresponding_CDS | LLC1.1a | |||||||
| Corresponding_transcript | LLC1.1b | ||||||||
| LLC1.1a.1 | |||||||||
| Other_sequence (42) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (23) | ||||||||
| Expr_pattern | Expr10020 | ||||||||
| Expr1022748 | |||||||||
| Expr1032737 | |||||||||
| Expr1154408 | |||||||||
| Expr2017477 | |||||||||
| Expr2035616 | |||||||||
| Drives_construct | WBCnstr00014644 | ||||||||
| WBCnstr00034274 | |||||||||
| Construct_product | WBCnstr00014653 | ||||||||
| WBCnstr00014659 | |||||||||
| WBCnstr00034274 | |||||||||
| Antibody | WBAntibody00001581 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (107) | |||||||||
| Interaction (108) | |||||||||
| WBProcess | WBbiopr:00000131 | ||||||||
| Map_info | Map | IV | Position | 12.0984 | |||||
| Well_ordered | |||||||||
| Positive | Positive_clone | CB#1412 | |||||||
| LLC1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point (4) | ||||||||
| Multi_point | 130 | ||||||||
| 131 | |||||||||
| 762 | |||||||||
| 1619 | |||||||||
| 1620 | |||||||||
| 1621 | |||||||||
| 1622 | |||||||||
| 3407 | |||||||||
| 3995 | |||||||||
| 5062 | |||||||||
| Pos_neg_data | 3269 | ||||||||
| 4680 | |||||||||
| 4692 | |||||||||
| 836 | |||||||||
| 4683 | |||||||||
| Landmark_gene | |||||||||
| Reference (148) | |||||||||
| Picture | WBPicture0000013095 | ||||||||
| Remark | Sequence connection from [Barnes TM, Hodgkin J, Kuwabara PE] | ||||||||
| Method | Gene |
