WormBase Tree Display for Gene: WBGene00006601
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| WBGene00006601 | SMap | S_parent | Sequence | Y17G7B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | tpi-1 | |||||||
| Sequence_name | Y17G7B.7 | ||||||||
| Molecular_name | Y17G7B.7 | ||||||||
| Y17G7B.7.1 | |||||||||
| CE19040 | |||||||||
| Other_name | TPI | Accession_evidence | EMBL | U23081 | |||||
| CELE_Y17G7B.7 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | tpi-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tpi | ||||||||
| Allele (77) | |||||||||
| Strain | WBStrain00051229 | ||||||||
| WBStrain00051910 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Contained_in_operon | CEOP2588 | ||||||||
| Ortholog (40) | |||||||||
| Structured_description | Concise_description | tpi-1 encodes a putative triosephosphate isomerase orthologous to human TPI1 (OMIM:190450, mutated in TPI deficiency) and Drosophila WASTED AWAY; loss of tpi-1 activity via RNAi results in increased resistance to exogenous oxidants and shortening of natural adult lifespan, both presumably due to alterations in the redox state of cells. | Paper_evidence | WBPaper00030350 | |||||
| WBPaper00031102 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 09 May 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable methylglyoxal synthase activity and triose-phosphate isomerase activity. Involved in cell redox homeostasis and determination of adult lifespan. Located in myofibril. Human ortholog(s) of this gene implicated in triosephosphate isomerase deficiency. Is an ortholog of human TPI1 (triosephosphate isomerase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050884 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12009) | ||||
| DOID:2978 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12009) | ||||||
| Molecular_info | Corresponding_CDS | Y17G7B.7 | |||||||
| Corresponding_transcript | Y17G7B.7.1 | ||||||||
| Other_sequence (179) | |||||||||
| Associated_feature | WBsf650640 | ||||||||
| WBsf666220 | |||||||||
| WBsf666221 | |||||||||
| WBsf666222 | |||||||||
| WBsf981304 | |||||||||
| WBsf224027 | |||||||||
| WBsf224028 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00027635 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00072188 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00072187 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00055586 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00020085 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00081173 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9365 | ||||||||
| Expr1019721 | |||||||||
| Expr1032732 | |||||||||
| Expr1159092 | |||||||||
| Expr2017465 | |||||||||
| Expr2035604 | |||||||||
| Construct_product | WBCnstr00013930 | ||||||||
| WBCnstr00016234 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (162) | |||||||||
| Interaction (60) | |||||||||
| Map_info | Map | II | Position | 5.96493 | Error | 0.041731 | |||
| Positive | Positive_clone | Y17G7B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
