WormBase Tree Display for Gene: WBGene00006571
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| WBGene00006571 | Evidence | Paper_evidence | WBPaper00003729 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CGC_data_submission | |||||||||
| SMap | S_parent | Sequence | Y75B8A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | tim-1 | Person_evidence | WBPerson540 | |||||
| Sequence_name | Y75B8A.22 | ||||||||
| Molecular_name | Y75B8A.22 | ||||||||
| Y75B8A.22.1 | |||||||||
| CE23033 | |||||||||
| Y75B8A.22.2 | |||||||||
| Other_name | csg-5 | ||||||||
| CELE_Y75B8A.22 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | tim-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tim | ||||||||
| Allele (263) | |||||||||
| Legacy_information | [Schnabel H] maternal effect embryonic lethal with defect in chromosome segregation during first cleavage | ||||||||
| Strain | WBStrain00007763 | ||||||||
| WBStrain00007806 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Ortholog (37) | |||||||||
| Structured_description | Concise_description | tim-1 encodes the C. elegans ortholog of mammalian timeless and Drosophila timeout proteins; in C. elegans, TIM-1 activity is essential for regulation of chromatid cohesion and thus, for proper meiotic and mitotic chromosome behavior and normal embryonic development; in addition, TIM-1 appears to also play a role in regulation of developmental timing, controlling the temporal identity of hypodermal seam cells during postembryonic development; during meiosis, TIM-1 activity is required for assembly of non-SMC members of the cohesin complex (REC-8 and SCC-3 in meiosis) onto chromosomes; immunoprecipitation experiments demonstrate that TIM-1 associates with mitotic cohesin subunits SMC-1, SMC-3, SCC-1, and SCC-3 in vivo, although TIM-1 is unlikely to be a core member of the cohesin complex but instead likely functions to regulate localization of non-SMC cohesin subunits to chromosomes; in mitotic cells, TIM-1 is present diffusely but most intensely in interphase nuclei and by the metaphase-to-anaphase transition, TIM-1 levels are much reduced and excluded from condensed chromatin; in germ cells, TIM-1 is diffuse in pre-meiotic nuclei, disappears abruptly as nuclei enter meiotic prophase, and then reappears in diplotene/diakinesis. | Paper_evidence | WBPaper00003729 | |||||
| WBPaper00005919 | |||||||||
| WBPaper00024931 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 31 Mar 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA binding activity. Involved in embryo development; regulation of sister chromatid cohesion; and sister chromatid cohesion. Located in nucleus. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome. Is an ortholog of human TIMELESS (timeless circadian regulator). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050628 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11813) | ||||
| Molecular_info | Corresponding_CDS | Y75B8A.22 | |||||||
| Corresponding_CDS_history | Y75B8A.22:wp59 | ||||||||
| Y75B8A.22:wp98 | |||||||||
| Corresponding_transcript | Y75B8A.22.1 | ||||||||
| Y75B8A.22.2 | |||||||||
| Other_sequence (14) | |||||||||
| Associated_feature | WBsf651533 | ||||||||
| WBsf667513 | |||||||||
| WBsf667514 | |||||||||
| WBsf667515 | |||||||||
| WBsf981615 | |||||||||
| WBsf994604 | |||||||||
| WBsf1016165 | |||||||||
| WBsf1016166 | |||||||||
| WBsf227645 | |||||||||
| WBsf227646 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00059905 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00059908 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059914 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00006901 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059909 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059916 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00058452 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2598 | ||||||||
| Expr1025187 | |||||||||
| Expr1032707 | |||||||||
| Expr1161868 | |||||||||
| Expr2017400 | |||||||||
| Expr2035539 | |||||||||
| Antibody | WBAntibody00000639 | ||||||||
| WBAntibody00000640 | |||||||||
| WBAntibody00002992 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (126) | |||||||||
| Interaction | WBInteraction000005369 | ||||||||
| WBInteraction000005370 | |||||||||
| WBInteraction000005371 | |||||||||
| WBInteraction000005372 | |||||||||
| WBInteraction000560690 | |||||||||
| WBInteraction000565552 | |||||||||
| WBInteraction000569474 | |||||||||
| WBInteraction000576778 | |||||||||
| WBProcess | WBbiopr:00000099 | ||||||||
| Map_info | Map | III | Position | 16.1962 | Error | 0.016436 | |||
| Positive | Inside_rearr | tDf5 | |||||||
| Positive_clone | Y75B8A | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | Multi_point | 5018 | |||||||
| 5667 | |||||||||
| Pos_neg_data | 10204 | ||||||||
| Reference (27) | |||||||||
| Remark | Sequence connection from [Jeon M, Rougvie AE, Gonczy P] | ||||||||
| old_name csg-5 becomes new_name tim-1 from [Jeon M, Rougvie AE, Gonczy P]. | |||||||||
| Method | Gene |
