WormBase Tree Display for Gene: WBGene00006556
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| WBGene00006556 | Evidence | Author_evidence | Woollard AS | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y47D3A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | tbx-37 | |||||||
| Sequence_name | Y47D3A.12 | ||||||||
| Molecular_name | Y47D3A.12 | ||||||||
| Y47D3A.12.1 | |||||||||
| CE44340 | |||||||||
| Other_name | CELE_Y47D3A.12 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | tbx-37 | ||||||||
| DB_info | Database | AceView | gene | 3M314 | |||||
| WormQTL | gene | WBGene00006556 | |||||||
| WormFlux | gene | WBGene00006556 | |||||||
| NDB | locus_tag | CELE_Y47D3A.12 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006556|UniProtKB=Q9U2C9 | |||||||
| family | PTHR11267 | ||||||||
| NCBI | gene | 189977 | |||||||
| RefSeq | protein | NM_067043.6 | |||||||
| SwissProt | UniProtAcc | Q9U2C9 | |||||||
| UniProt_GCRP | UniProtAcc | Q9U2C9 | |||||||
| OMIM | gene | 300307 | |||||||
| 601719 | |||||||||
| 602427 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tbx | ||||||||
| Allele (38) | |||||||||
| Strain | WBStrain00050742 | ||||||||
| WBStrain00050741 | |||||||||
| WBStrain00050740 | |||||||||
| WBStrain00050739 | |||||||||
| WBStrain00051019 | |||||||||
| WBStrain00051968 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (78) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | tbx-37 encodes a T box transcription factor; during embryonic development, tbx-37 functions redundantly with tbx-38 to effect Notch-mediated pharyngeal mesoderm induction in descendants of the ABa blastomere; in addition, tbx-37 and tbx-38 are required for proper cell fate specification of other ABa descendants, such as those that give rise to hypodermal tissue; a tbx-37::gfp fusion is expressed exclusively in the 8 ABa descendents at the 24-cell stage of embryogenesis; negative regulation of tbx-37 expression in ABp descendants depends upon Notch signaling, while negative regulation of expression in both ABp and EMS descendents appears to be controlled by members of the REF-1 family of bHLH transcriptions factors, specifically REF-1, HLH-26, HLH-27, and HLH-29. | Paper_evidence | WBPaper00013403 | |||||
| WBPaper00025235 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 01 Feb 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in pharynx development. Located in nucleus. Expressed in head neurons. Human ortholog(s) of this gene implicated in Abruzzo-Erickson syndrome; X-linked cleft palate with or without ankyloglossia; and bone disease (multiple). Is an ortholog of several human genes including TBX15 (T-box transcription factor 15); TBX4 (T-box transcription factor 4); and TBX6 (T-box transcription factor 6). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111382 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11603) | ||||
| DOID:381 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11603) | ||||||
| DOID:0111826 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11600) | ||||||
| DOID:0112363 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11605) | ||||||
| DOID:674 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11600) | ||||||
| DOID:0060613 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11600) | ||||||
| Molecular_info | Corresponding_CDS | Y47D3A.12 | |||||||
| Corresponding_CDS_history | Y47D3A.12:wp209 | ||||||||
| Corresponding_transcript | Y47D3A.12.1 | ||||||||
| Other_sequence | CR06287 | ||||||||
| CRC10308_1 | |||||||||
| Associated_feature | WBsf651497 | ||||||||
| WBsf978782 | |||||||||
| WBsf994307 | |||||||||
| WBsf994308 | |||||||||
| WBsf1015952 | |||||||||
| WBsf1015953 | |||||||||
| WBsf227557 | |||||||||
| Transcription_factor | WBTranscriptionFactor000213 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00056731 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00006920 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2925 | ||||||||
| Expr7717 | |||||||||
| Expr10452 | |||||||||
| Expr10453 | |||||||||
| Expr1032698 | |||||||||
| Expr1160198 | |||||||||
| Expr2017352 | |||||||||
| Expr2035489 | |||||||||
| Drives_construct | WBCnstr00001748 | ||||||||
| WBCnstr00006262 | |||||||||
| WBCnstr00012862 | |||||||||
| WBCnstr00015338 | |||||||||
| Construct_product | WBCnstr00016170 | ||||||||
| Microarray_results (14) | |||||||||
| Expression_cluster (99) | |||||||||
| Interaction (36) | |||||||||
| Map_info | Map | III | Position | 7.52439 | Error | 0.10175 | |||
| Positive | Positive_clone | Y47D3A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (23) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
