WormBase Tree Display for Gene: WBGene00006476
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| WBGene00006476 | SMap | S_parent | Sequence | T08H4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | rhgf-2 | Person_evidence | WBPerson3043 | |||||
| Sequence_name | T08H4.1 | ||||||||
| Molecular_name (15) | |||||||||
| Other_name | tag-127 | Person_evidence | WBPerson201 | ||||||
| CELE_T08H4.1 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | rhgf-2 | ||||||||
| DB_info | Database | AceView | gene | 2E417 | |||||
| WormQTL | gene | WBGene00006476 | |||||||
| WormFlux | gene | WBGene00006476 | |||||||
| NDB | locus_tag | CELE_T08H4.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006476|UniProtKB=S6EZU2 | |||||||
| family | PTHR13217 | ||||||||
| NCBI | gene | 173748 | |||||||
| RefSeq | protein | NM_001381382.1 | |||||||
| NM_001381384.1 | |||||||||
| NM_001383815.1 | |||||||||
| TrEMBL | UniProtAcc | Q22354 | |||||||
| S6EZU2 | |||||||||
| I1W6S5 | |||||||||
| UniProt_GCRP | UniProtAcc | S6EZU2 | |||||||
| OMIM | gene | 611101 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 24 May 2007 08:50:44 | WBPerson2970 | Name_change | CGC_name | rhgf-2 | ||||
| 3 | 18 Jun 2013 10:56:50 | WBPerson615 | Event | Acquires_merge | WBGene00020367 | ||||
| Acquires_merge | WBGene00020367 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rhgf | ||||||||
| Allele (546) | |||||||||
| Strain | WBStrain00002248 | ||||||||
| WBStrain00001994 | |||||||||
| WBStrain00035783 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | rhgf-2 encodes a Rho guanyl-nucleotide exchange factor (RhoGEF) with similarity to the mammalian PLEKHG5/Tech/Syx RhoGEFs; rhgf-2 is required for embryonic morphogenesis, larval development, and regulation of locomotion; when expressed in mammalian neuronal tissue culture cells, RHGF-2 induces cell rounding inhibits neurite outgrowth; RHGF-2 functions as a RhoGEF for the RHO-1 GTPase; RHGF-2 physically interacts with the multi-PDZ domain scaffold protein MPZ-1; RHGF-2 is expressed in many, but not all, C. elegans neurons from the 1.5-fold stage of embryogenesis through adulthood; in nerve ring axons, RHGF-2 expression overlaps with that of MPZ-1. | Paper_evidence | WBPaper00040835 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 14 Jun 2013 00:00:00 | ||||||||
| Automated_description | Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including Rho protein signal transduction; embryonic body morphogenesis; and positive regulation of transcription by RNA polymerase II. Located in axon and cell body. Expressed in several structures, including pharyngeal cell; seam cell; somatic nervous system; tail; and touch receptor neurons. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and distal spinal muscular atrophy type 4. Is an ortholog of human PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110198 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29105) | ||||
| DOID:0111213 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29105) | ||||||
| Molecular_info | Corresponding_CDS | T08H4.1a | |||||||
| T08H4.1b | |||||||||
| T08H4.1c | |||||||||
| Corresponding_transcript | T08H4.1a.1 | ||||||||
| T08H4.1a.2 | |||||||||
| T08H4.1a.3 | |||||||||
| T08H4.1a.4 | |||||||||
| T08H4.1a.5 | |||||||||
| T08H4.1b.1 | |||||||||
| T08H4.1b.2 | |||||||||
| T08H4.1b.3 | |||||||||
| T08H4.1c.1 | |||||||||
| Other_sequence (18) | |||||||||
| Associated_feature (31) | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern (15) | |||||||||
| Drives_construct | WBCnstr00002778 | ||||||||
| WBCnstr00004413 | |||||||||
| WBCnstr00011905 | |||||||||
| WBCnstr00014583 | |||||||||
| WBCnstr00014584 | |||||||||
| WBCnstr00014585 | |||||||||
| WBCnstr00014586 | |||||||||
| WBCnstr00014587 | |||||||||
| Construct_product | WBCnstr00014585 | ||||||||
| WBCnstr00014586 | |||||||||
| WBCnstr00014587 | |||||||||
| Antibody | WBAntibody00002646 | ||||||||
| Microarray_results (34) | |||||||||
| Expression_cluster (174) | |||||||||
| Interaction (65) | |||||||||
| Map_info | Map | II | Position | -5.62283 | |||||
| Positive | Positive_clone | T08H4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4906 | |||||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
