WormBase Tree Display for Gene: WBGene00006385

WBGene00006385 SMap: S_parent: Sequence: R119
  Identity: Version: 1
    Name: CGC_name: taf-4
      Sequence_name: R119.6
      Molecular_name: R119.6
        R119.6.1
        CE39613
      Other_name: CELE_R119.6 Accession_evidence: NDB BX284601
      Public_name: taf-4
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: taf
    Allele (124)
    Strain: WBStrain00036170
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog: WBGene00060550 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00040741 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00162243 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00161706 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00131205 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00270845 Caenorhabditis briggsae From_analysis: WormBase-Compara
      WBGene00225679 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g12334 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP26.g12027 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g11519 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g11015 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g10772 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g8826 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g8003 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g28031 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g10545 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_01408.g16382 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-taf-4 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold508.g2486 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01832.g23411 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_22095 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_23323 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_001112 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g10713 Oscheius tipulae From_analysis: WormBase-Compara
      Sp34_10251600 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g65 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00241154 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00259342 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00292081 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000004607 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Panther
      FB:FBgn0010280 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
      ZFIN:ZDB-GENE-090313-238 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-131127-579 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
      ZFIN:ZDB-GENE-070424-105 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
      HGNC:11537 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
      HGNC:11538 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
      MGI:2152345 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
      MGI:2152346 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
      RGD:1562997 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
      RGD:1588072 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            OrthoInspector
            Panther
    Structured_description: Concise_description: taf-4 encodes a TAFII (TBP(TATA-binding protein)-associated factor) that is orthologous to human TAF4 (hTAFII130); TAF-4 is predicted to be a component of the TFIID mRNA transcription complex and is generally required for early embryonic mRNA transcription; consistent with this observation, taf-4(RNAi) results in embryonic lethality at the ~100-cell stage with little cell differentiation, similar to the loss of AMA-1/RNA polymerase II activity; TAF-4 is detected in nuclei in the adult germline, oocytes, and embryo, from the 2-cell stage through early morphogenesis. Paper_evidence: WBPaper00004890
          Curator_confirmed: WBPerson1843
          Date_last_updated: 26 Jan 2005 00:00:00
      Automated_description: Predicted to enable DNA binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in several processes, including determination of adult lifespan; regulation of mitotic cell cycle, embryonic; and transcription initiation at RNA polymerase II promoter. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in spermatogenic failure 13. Is an ortholog of human TAF4B (TATA-box binding protein associated factor 4b). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070182 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11538)
  Molecular_info: Corresponding_CDS: R119.6
    Corresponding_CDS_history: R119.6:wp153
    Corresponding_transcript: R119.6.1
    Other_sequence (39)
    Associated_feature: WBsf643011
      WBsf980924
      WBsf982485
      WBsf1009079
      WBsf217127
      WBsf217128
    Transcription_factor (2)
  Experimental_info: RNAi_result (40)
    Expr_pattern: Expr1027683
      Expr1032582
      Expr1155419
      Expr2017214
      Expr2035350
    Construct_product: WBCnstr00005322
      WBCnstr00005323
    Antibody: WBAntibody00000409
    Microarray_results (21)
    Expression_cluster (84)
    Interaction (90)
  Map_info: Map: I Position: -19.0465 Error: 0.003066
    Positive: Positive_clone: R119 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (17)
  Remark: Sequence connection from [source: A Walker]
    This gene was previously called taf-5. [krb 020614]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene