WormBase Tree Display for Gene: WBGene00006385

WBGene00006385 SMap: S_parent: Sequence: R119
  Identity: Version: 1
    Name: CGC_name: taf-4
      Sequence_name: R119.6
      Molecular_name: R119.6
        R119.6.1
        CE39613
      Other_name: CELE_R119.6 Accession_evidence: NDB BX284601
      Public_name: taf-4
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: taf
    Allele (124)
    Strain: WBStrain00036170
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog (40)
    Structured_description: Concise_description: taf-4 encodes a TAFII (TBP(TATA-binding protein)-associated factor) that is orthologous to human TAF4 (hTAFII130); TAF-4 is predicted to be a component of the TFIID mRNA transcription complex and is generally required for early embryonic mRNA transcription; consistent with this observation, taf-4(RNAi) results in embryonic lethality at the ~100-cell stage with little cell differentiation, similar to the loss of AMA-1/RNA polymerase II activity; TAF-4 is detected in nuclei in the adult germline, oocytes, and embryo, from the 2-cell stage through early morphogenesis. Paper_evidence: WBPaper00004890
          Curator_confirmed: WBPerson1843
          Date_last_updated: 26 Jan 2005 00:00:00
      Automated_description: Predicted to enable DNA binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in several processes, including determination of adult lifespan; regulation of mitotic cell cycle, embryonic; and transcription initiation at RNA polymerase II promoter. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in spermatogenic failure 13. Is an ortholog of human TAF4B (TATA-box binding protein associated factor 4b). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070182 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11538)
  Molecular_info: Corresponding_CDS: R119.6
    Corresponding_CDS_history: R119.6:wp153
    Corresponding_transcript: R119.6.1
    Other_sequence (39)
    Associated_feature: WBsf643011
      WBsf980924
      WBsf982485
      WBsf1009079
      WBsf217127
      WBsf217128
    Transcription_factor (2)
  Experimental_info: RNAi_result (40)
    Expr_pattern: Expr1027683
      Expr1032582
      Expr1155419
      Expr2017214
      Expr2035350
    Construct_product: WBCnstr00005322
      WBCnstr00005323
    Antibody: WBAntibody00000409
    Microarray_results (21)
    Expression_cluster (84)
    Interaction: WBInteraction000035721
      WBInteraction000035722
      WBInteraction000036201
      WBInteraction000039717
      WBInteraction000106940
      WBInteraction000107186
      WBInteraction000107187
      WBInteraction000107192
      WBInteraction000107398
      WBInteraction000108944
      WBInteraction000108983
      WBInteraction000108984
      WBInteraction000108988
      WBInteraction000108995
      WBInteraction000109001
      WBInteraction000125032
      WBInteraction000125036
      WBInteraction000127643
      WBInteraction000130429
      WBInteraction000130430
      WBInteraction000130431
      WBInteraction000130432
      WBInteraction000130433
      WBInteraction000130434
      WBInteraction000130435
      WBInteraction000130436
      WBInteraction000130437
      WBInteraction000130438
      WBInteraction000130439
      WBInteraction000130440
      WBInteraction000130441
      WBInteraction000130740
      WBInteraction000130892
      WBInteraction000131251
      WBInteraction000131456
      WBInteraction000131863
      WBInteraction000131976
      WBInteraction000132352
      WBInteraction000132479
      WBInteraction000132570
      WBInteraction000132695
      WBInteraction000132776
      WBInteraction000135610
      WBInteraction000151152
      WBInteraction000158923
      WBInteraction000164388
      WBInteraction000166952
      WBInteraction000167600
      WBInteraction000169815
      WBInteraction000172865
      WBInteraction000173870
      WBInteraction000192729
      WBInteraction000208386
      WBInteraction000303038
      WBInteraction000304724
      WBInteraction000316114
      WBInteraction000320008
      WBInteraction000323647
      WBInteraction000329397
      WBInteraction000330973
      WBInteraction000339709
      WBInteraction000339711
      WBInteraction000345293
      WBInteraction000347707
      WBInteraction000347899
      WBInteraction000357966
      WBInteraction000369751
      WBInteraction000373647
      WBInteraction000375852
      WBInteraction000390854
      WBInteraction000395844
      WBInteraction000405852
      WBInteraction000409881
      WBInteraction000411847
      WBInteraction000416143
      WBInteraction000428327
      WBInteraction000433359
      WBInteraction000451780
      WBInteraction000460256
      WBInteraction000501846
      WBInteraction000503813
      WBInteraction000519298
      WBInteraction000540900
      WBInteraction000540904
      WBInteraction000540905
      WBInteraction000556341
      WBInteraction000556342
      WBInteraction000561274
      WBInteraction000564327
      WBInteraction000577261
  Map_info: Map: I Position: -19.0465 Error: 0.003066
    Positive: Positive_clone: R119 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (17)
  Remark: Sequence connection from [source: A Walker]
    This gene was previously called taf-5. [krb 020614]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene