WormBase Tree Display for Gene: WBGene00006385
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| WBGene00006385 | SMap | S_parent | Sequence | R119 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | taf-4 | |||||||
| Sequence_name | R119.6 | ||||||||
| Molecular_name | R119.6 | ||||||||
| R119.6.1 | |||||||||
| CE39613 | |||||||||
| Other_name | CELE_R119.6 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | taf-4 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | taf | ||||||||
| Allele (124) | |||||||||
| Strain | WBStrain00036170 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (40) | |||||||||
| Structured_description | Concise_description | taf-4 encodes a TAFII (TBP(TATA-binding protein)-associated factor) that is orthologous to human TAF4 (hTAFII130); TAF-4 is predicted to be a component of the TFIID mRNA transcription complex and is generally required for early embryonic mRNA transcription; consistent with this observation, taf-4(RNAi) results in embryonic lethality at the ~100-cell stage with little cell differentiation, similar to the loss of AMA-1/RNA polymerase II activity; TAF-4 is detected in nuclei in the adult germline, oocytes, and embryo, from the 2-cell stage through early morphogenesis. | Paper_evidence | WBPaper00004890 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 26 Jan 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in several processes, including determination of adult lifespan; regulation of mitotic cell cycle, embryonic; and transcription initiation at RNA polymerase II promoter. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in spermatogenic failure 13. Is an ortholog of human TAF4B (TATA-box binding protein associated factor 4b). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070182 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11538) | ||||
| Molecular_info | Corresponding_CDS | R119.6 | |||||||
| Corresponding_CDS_history | R119.6:wp153 | ||||||||
| Corresponding_transcript | R119.6.1 | ||||||||
| Other_sequence (39) | |||||||||
| Associated_feature | WBsf643011 | ||||||||
| WBsf980924 | |||||||||
| WBsf982485 | |||||||||
| WBsf1009079 | |||||||||
| WBsf217127 | |||||||||
| WBsf217128 | |||||||||
| Transcription_factor | WBTranscriptionFactor000206 | ||||||||
| WBTranscriptionFactor000442 | |||||||||
| Experimental_info | RNAi_result (40) | ||||||||
| Expr_pattern | Expr1027683 | ||||||||
| Expr1032582 | |||||||||
| Expr1155419 | |||||||||
| Expr2017214 | |||||||||
| Expr2035350 | |||||||||
| Construct_product | WBCnstr00005322 | ||||||||
| WBCnstr00005323 | |||||||||
| Antibody | WBAntibody00000409 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (84) | |||||||||
| Interaction (90) | |||||||||
| Map_info | Map | I | Position | -19.0465 | Error | 0.003066 | |||
| Positive | Positive_clone | R119 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Sequence connection from [source: A Walker] | ||||||||
| This gene was previously called taf-5. [krb 020614] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
