WormBase Tree Display for Gene: WBGene00006382

WBGene00006382 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: taf-1
      Sequence_name: W04A8.7
      Molecular_name: W04A8.7a
        W04A8.7a.1
        CE42634
        W04A8.7b
        CE54397
        W04A8.7b.1
      Other_name: Y71A12B.b Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_W04A8.7 Accession_evidence: NDB BX284601
      Public_name: taf-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: taf
    Allele (397)
    RNASeq_FPKM (74)
    GO_annotation (23)
    Contained_in_operon: CEOP1728
    Ortholog (42)
    Structured_description: Concise_description: The taf-1 gene encodes an ortholog of human TATA-binding protein associated factor TAF1L (TAFII250) that possesses histone acetyl transferase (HAT) activity and is a component of the TFIID general transcription factor that recognizes the transcription start site; TAF-1 is required for proper embryonic and larval development. Paper_evidence: WBPaper00004402
            WBPaper00004890
            WBPaper00005654
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable several functions, including RNA polymerase II general transcription initiation factor activity; TBP-class protein binding activity; and histone acetyltransferase activity. Predicted to contribute to transcription cis-regulatory region binding activity. Involved in embryo development and transcription initiation at RNA polymerase II promoter. Located in nucleus. Human ortholog(s) of this gene implicated in X-linked dystonia-parkinsonism and syndromic X-linked intellectual disability. Is an ortholog of human TAF1L (TATA-box binding protein associated factor 1 like). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0090057 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11535)
      DOID:0060309 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11535)
  Molecular_info: Corresponding_CDS: W04A8.7a
      W04A8.7b
    Corresponding_CDS_history: W04A8.7:wp20
      W04A8.7:wp191
    Corresponding_transcript: W04A8.7a.1
      W04A8.7b.1
    Other_sequence (53)
    Associated_feature: WBsf643820
      WBsf657050
      WBsf985962
      WBsf985963
      WBsf985964
      WBsf1011126
      WBsf1011127
      WBsf218758
    Transcription_factor: WBTranscriptionFactor000206
      WBTranscriptionFactor000421
  Experimental_info: RNAi_result (32)
    Expr_pattern: Expr1027270
      Expr1032579
      Expr1158287
      Expr2017211
      Expr2035347
    Antibody: WBAntibody00000731
    Microarray_results (23)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_embryo_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_embryo_enriched
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_downregulated_N2
      WBPaper00049942:HeatShock_downregulated_hsf-1(+)
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F1_morc-1(tm6048)_downregulated
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055897:heat-shock_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061274:microgravity_upregulated
      WBPaper00061340:AIN_parent
      WBPaper00061340:Neuroblast_M2_M3
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:gpb-1_3783-C48A7.2_22459
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00036123:Atrazine_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00040823:alg-1(gk214)_downregulated
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:TA200_up
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-exposed_3h
      WBPaper00041939:control_vs_UVC-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00048624:hlh-25(ok1710)_downregulated
      [cgc6390]:herm_sex-enriched
    Interaction (177)
  Map_info: Map: I Position: 22.0627 Error: 0.064158
    Positive: Positive_clone: W04A8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4888
        4903
        5555
    Pseudo_map_position
  Reference (14)
  Remark: Sequence connection from [source: A Walker]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene