WormBase Tree Display for Gene: WBGene00006367

WBGene00006367 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 2
    Name: CGC_name: sym-2 Person_evidence: WBPerson252
      Sequence_name: ZK1067.6
      Molecular_name: ZK1067.6a
        ZK1067.6a.1
        CE35148
        ZK1067.6b
        CE03707
        ZK1067.6b.1
      Other_name: CELE_ZK1067.6 Accession_evidence: NDB BX284602
      Public_name: sym-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 19 Aug 2005 11:42:03 WBPerson2970 Event: Acquires_merge: WBGene00014211
      Acquires_merge: WBGene00014211
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sym
    Allele: WBVar00754719
      WBVar00754720
      WBVar00754721
      WBVar01499702
      WBVar00754722
      WBVar00266278
      WBVar00754723
      WBVar00754724
      WBVar00754725
      WBVar00754726
      WBVar00754727
      WBVar00754728
      WBVar00754729
      WBVar00754730
      WBVar00754731
      WBVar00754732
      WBVar00754733
      WBVar00754734
      WBVar00754735
      WBVar00754736
      WBVar01604416
      WBVar00227715
      WBVar01604417
      WBVar00754737
      WBVar00227717
      WBVar00754738
      WBVar00754739
      WBVar00754740
      WBVar00754741
      WBVar00754742
      WBVar00552122
      WBVar00754743
      WBVar01498435
      WBVar00754744
      WBVar00754745
      WBVar00754746
      WBVar00754747
      WBVar00754748
      WBVar00754749
      WBVar00754750
      WBVar00246392
      WBVar00754752
      WBVar00754753
      WBVar00754754
      WBVar00754755
      WBVar00754756
      WBVar00754757
      WBVar00754758
      WBVar00754759
      WBVar00754760
      WBVar00754761
      WBVar00754762
      WBVar00754763
      WBVar00754764
      WBVar00754765
      WBVar00754766
      WBVar00754767
      WBVar00754768
      WBVar01439000
      WBVar01439001
      WBVar00754769
      WBVar00754770
      WBVar01439002
      WBVar00754771
      WBVar00754772
      WBVar01499017
      WBVar00278226
      WBVar00174506
      WBVar00174507
      WBVar00174508
      WBVar00174509
      WBVar00174510
      WBVar00105268
      WBVar01784331
      WBVar01559650
      WBVar01949246
      WBVar00309766
      WBVar00309767
      WBVar01243003
      WBVar02130453
      WBVar01243004
      WBVar02130454
      WBVar01243006
      WBVar02130455
      WBVar01243011
      WBVar00277337
      WBVar00277338
      WBVar01538374
      WBVar01377255
      WBVar02002906
      WBVar01377268
      WBVar00373584
      WBVar01309212
      WBVar01309213
      WBVar00373585
      WBVar00373586
      WBVar00373587
      WBVar00373588
      WBVar00373589
      WBVar00373590
      WBVar00373591
      WBVar00373592
      WBVar00373593
      WBVar01494497
      WBVar00373594
      WBVar00373595
      WBVar00373596
      WBVar00373597
      WBVar00373598
      WBVar01252683
      WBVar00373599
      WBVar00373600
      WBVar00373601
      WBVar00373602
      WBVar00373603
      WBVar00373604
      WBVar01493404
      WBVar00373605
      WBVar01252695
      WBVar00373606
      WBVar00373607
      WBVar00373608
      WBVar00373609
      WBVar00373610
      WBVar00089184
      WBVar00373611
      WBVar00373612
      WBVar00373613
      WBVar00373614
      WBVar01666384
      WBVar01498940
      WBVar00602427
      WBVar00754703
      WBVar01477788
      WBVar00754704
      WBVar00754705
      WBVar01477789
      WBVar00754706
      WBVar01477790
      WBVar00754707
      WBVar00754708
      WBVar00754709
      WBVar01696098
      WBVar00754710
      WBVar00754711
      WBVar01696099
      WBVar00754712
      WBVar00754713
      WBVar00754714
      WBVar00754715
      WBVar00754716
      WBVar00754717
      WBVar00754718
    Legacy_information: [Herman RK] sym-2(mn617) by itself is essentially wild type but is synthetic lethal with any mec-8 loss-of-function mutation
    Strain: WBStrain00034404
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (49)
    Paralog: WBGene00013703 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022253 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00020936 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: sym-2 encodes a predicted RNA binding protein that contains three RNA recognition motifs (RRMs) similar to those of Drosophila Fusilli and mammalian hnRNP F and H; genetic analyses indicate that, during embryonic development, sym-2 functions redundantly with mec-8, which also encodes an RRM-containing protein, to affect the structure of body wall muscles or their attachment to the body cuticle, perhaps by regulating maturation of transcripts essential for muscle development. Paper_evidence: WBPaper00003663
            WBPaper00024639
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 04 May 2006 00:00:00
      Automated_description: Predicted to enable mRNA binding activity. Involved in embryo development; embryonic body morphogenesis; and multicellular organismal movement. Predicted to be located in nucleoplasm. Predicted to be part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 109. Is an ortholog of human ESRP1 (epithelial splicing regulatory protein 1) and ESRP2 (epithelial splicing regulatory protein 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111639 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:25966)
  Molecular_info: Corresponding_CDS: ZK1067.6a
      ZK1067.6b
    Corresponding_CDS_history: ZK1067.6:wp106
    Corresponding_transcript: ZK1067.6a.1
      ZK1067.6b.1
    Associated_feature (20)
  Experimental_info: RNAi_result: WBRNAi00062554 Inferred_automatically: RNAi_primary
      WBRNAi00095006 Inferred_automatically: RNAi_primary
      WBRNAi00062552 Inferred_automatically: RNAi_primary
      WBRNAi00022509 Inferred_automatically: RNAi_primary
      WBRNAi00038138 Inferred_automatically: RNAi_primary
      WBRNAi00062553 Inferred_automatically: RNAi_primary
      WBRNAi00059094 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1019298
      Expr1032566
      Expr1162524
      Expr2017180
      Expr2035316
    Drives_construct: WBCnstr00034387
    Construct_product: WBCnstr00034387
    Microarray_results (19)
    Expression_cluster (205)
    Interaction: WBInteraction000033615
      WBInteraction000142468
      WBInteraction000178962
      WBInteraction000209724
      WBInteraction000210016
      WBInteraction000217195
      WBInteraction000220838
      WBInteraction000256329
      WBInteraction000257576
      WBInteraction000259183
      WBInteraction000261109
      WBInteraction000287321
      WBInteraction000290195
      WBInteraction000315237
      WBInteraction000317572
      WBInteraction000325319
      WBInteraction000373950
      WBInteraction000384910
      WBInteraction000394395
      WBInteraction000396828
      WBInteraction000399319
      WBInteraction000425246
      WBInteraction000503340
      WBInteraction000547281
      WBInteraction000547658
      WBInteraction000547997
      WBInteraction000548506
      WBInteraction000548694
      WBInteraction000548864
      WBInteraction000575916
  Map_info: Map: II Position: 1.09265 Error: 0.000921
    Positive: Positive_clone: ZK1067 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 7090
        7091
  Reference (18)
  Method: Gene