WormBase Tree Display for Gene: WBGene00005156
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| WBGene00005156 | Identity | Version | 1 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | CGC_name | srf-6 | Person_evidence | WBPerson494 | |||||
| Public_name | srf-6 | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Gene_class | srf | |||||||
| Allele | WBVar00275414 | Inferred_automatically | From strain object: AT18 | ||||||
| From strain object: AT28 | |||||||||
| WBVar00275415 | Inferred_automatically | From strain object: AT24 | |||||||
| WBVar00275416 | Inferred_automatically | From strain object: AT25 | |||||||
| WBVar00275410 | |||||||||
| WBVar00275417 | |||||||||
| Legacy_information | [Grenache DG] srf for SuRFace antigen. Animal express an L1-specific antigen detected by mouse monoclonal antibodies M37 and M38 at stages L1 - L4 but not as adults. No visible phenotype. | ||||||||
| [Grenache DG] srf for SuRFace antigen. Animal express an L1-specific antigen detected by mouse monoclonal antibodies M37 and M38 at stages L1 - L4 but not as adults. No visible phenotype. | |||||||||
| [C.elegansII] yj13 : all larval stages (but not adult) label with L1-specific mAbs M37, M38. Gross phenotype WT. See also daf-1,4,7,8,11,14. OA4: yj41, yj43, yj5, yj15. [AT; DR] | |||||||||
| Complementation_data | [Grenache DG] Reference allele yj13 fails to complement yj5, yj15, yj41, and yj43 | ||||||||
| Strain | WBStrain00047205 | ||||||||
| WBStrain00047206 | |||||||||
| WBStrain00047204 | |||||||||
| WBStrain00047203 | |||||||||
| Structured_description | Concise_description | srf-6 was identified in surface immunofluorescence screens for mutants that show constitutive larval display (CLD) of the L1 epitope on all four larval stages; normally wild-type worms can be induced to display a first larval stage (L1) epitope in response to environmental signals, known as the inducible larval display (ILD); srf-6 is required for chemotaxis, similar to the genes osm-3 (a cytoplasmic kinesin), che-3 (a cyotosolic dynein heavy chain), and tax-4 (a cyclic-nucleotide-gated ion channel subunit), whose mutants show reduced ILD and block the CLD of srf-6; srf-6 interacts with the genes in the TGF-beta like pathway like daf-14 to enhance the dauer-constitutive phenotype; srf-6 mutants are also resistant to the attachment of Yersinia biofilms; thus srf-6 may play a regulatory role in the overlapping functions of chemotaxis, dauer formation and surface determination. | Paper_evidence | WBPaper00002589 | |||||
| WBPaper00028386 | |||||||||
| WBPaper00029153 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 04 Oct 2011 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:104 | Homo sapiens | Paper_evidence | WBPaper00029153 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 07 Nov 2023 00:00:00 | ||||||||
| Disease_relevance | C. elegans is used as a model system to study bacterial adherence via biofilm formation and to identify genes in the infectious agent as well as the host that are required for infection; elegans srf genes are required for cuticle surface properties like binding to antigens, and for the adherence of bacterial pathogens like Yersinia pseduotuberculosis and Yersinia pestis via biofilms. | Homo sapiens | Paper_evidence | WBPaper00001706 | |||||
| WBPaper00026735 | |||||||||
| WBPaper00029153 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Mar 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000018 | ||||||||
| Experimental_info | Interaction (18) | ||||||||
| Map_info | Map | II | Position | 0.106368 | Error | 0.015512 | |||
| Well_ordered | |||||||||
| Mapping_data | Multi_point | 2653 | |||||||
| 2654 | |||||||||
| 2655 | |||||||||
| 2657 | |||||||||
| 2658 | |||||||||
| 2659 | |||||||||
| Pos_neg_data | 7204 | ||||||||
| 7205 | |||||||||
| 7206 | |||||||||
| 7209 | |||||||||
| 7210 | |||||||||
| Reference (25) | |||||||||
| Method | Gene |
