[C.elegansII] NMK. Encodes predicted serpentine receptor.sra-6:GFP expressed in sensory neurons ASH,ASI (fain t), interneuron PVQ; also in male spicule neurons SPD/SPV. sra-1 to sra-9 clustered. [Troemel et al. 1995; CX]
sra-6 encodes a seven-transmembrane chemosensory receptor; an sra-6::GFP fusion reporter is expressed in the ASH (strongly) and ASI (weakly) amphid sensory neurons, the PVQ interneurons, and in the SPD and SPV male spicule neurons; sra-6 expression in the ASH neurons is positively regulated by KIN-29, a serine/threonine kinase, acting through the HDA-4 class II histone deacetylase and the MEF-2 MADS domain transcription factor; in addition, maintenance of sra-6::gfp expression in the ASH and ASI requires activity of the DAF-7/TGF-beta signaling pathway.
Predicted to enable olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception. Located in cilium. Expressed in head and tail.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.