sc63ts : homozygotes at 25x are non-roller dumpy heterozygotes sc63/+ are non-dumpy left-handed roller in adult high penetrance deformed tail at 25x. ES3 ME0 (25x). At 15x slightly dumpy. NA > 8 (sc80ts (resembles sc63) e24sd ts (pka dpy-15 : dumpy inviable at 25x e24/+ dumpy at 25x) etc.).
See sqt-3.
See also e24, e2117
[C.elegansII] sc63ts,sd : homozygotes at 25C are non-roller dumpy, heterozygotes sc63/+ are non-dumpy left-handed roller in adult; high penetrance deformed tail at 25C. ES3 ME0 (25C). At 15C slightly dumpy. OA3: sc80ts (resembles sc63), e24sd,ts (pka dpy-15, dumpy inviable at 25C, e24/+ dumpy at 25C, sometimes Lon at15C), sc42 (recessive left roller), e2117ts (extreme dumpy early larval lethal at 25C). Cloned: encodes 295 aa collagen (pka col-1), dpy-13 family; mutations all missense; expressed at each larval stage, 4 - 2.5 hours before lethargus. [Kramer et al. 1982; Keyl et al. 1994; IA]
sc8 : adults and L4 larvae left-handed rollers. ES3 (adult) ME2. NA3 (b238ts : at 25x rolls only in adult at 16x wildtype).
[C.elegansII] sc8 : adults and L4 larvae left-handed rollers. ES3 (adult) ME2. OA2: b238ts (at 25C rolls only in adult, WT at 16C). [Cox et al. 1980]
sqt-3 encodes a cuticle collagen; during development, sqt-3 activity is essential for viability and normal body morphology; genetic and expression studies indicate that SQT-3 is a cuticle component at all stages of development and that SQT-3 likely forms higher order cuticular structures with the DPY-17 cuticular collagen, both of which are candidate substrates for the DPY-31 procollagen C-proteinase.
Predicted to be a structural constituent of cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Located in collagen and cuticulin-based cuticle extracellular matrix. Expressed in hypodermis.