WormBase Tree Display for Gene: WBGene00005008
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| WBGene00005008 | Evidence | Paper_evidence | WBPaper00005903 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C07A12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | spr-3 | Person_evidence | WBPerson220 | |||||
| Sequence_name | C07A12.5 | ||||||||
| Molecular_name | C07A12.5a | ||||||||
| C07A12.5a.1 | |||||||||
| CE36266 | |||||||||
| C07A12.5b | |||||||||
| CE53297 | |||||||||
| C07A12.5b.1 | |||||||||
| Other_name | CELE_C07A12.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | spr-3 | ||||||||
| DB_info | Database | AceView | gene | XF135 | |||||
| WormQTL | gene | WBGene00005008 | |||||||
| WormFlux | gene | WBGene00005008 | |||||||
| OMIM | gene | 600571 | |||||||
| NDB | locus_tag | CELE_C07A12.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00005008|UniProtKB=Q17768 | |||||||
| family | PTHR24403 | ||||||||
| NCBI | gene | 180722 | |||||||
| RefSeq | protein | NM_001373281.4 | |||||||
| NM_001029196.5 | |||||||||
| SwissProt | UniProtAcc | Q17768 | |||||||
| UniProt_GCRP | UniProtAcc | Q17768 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spr | ||||||||
| Allele (56) | |||||||||
| Legacy_information | [Iva Greenwald] suppressor of sel-12 presenilin Egl phenotype | ||||||||
| Strain | WBStrain00024092 | ||||||||
| WBStrain00032615 | |||||||||
| WBStrain00004785 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00059128 | ||||||||
| 00059129 | |||||||||
| 00059130 | |||||||||
| 00059131 | |||||||||
| 00059132 | |||||||||
| 00059133 | |||||||||
| Ortholog (14) | |||||||||
| Paralog | WBGene00003002 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00003218 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00009508 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00009834 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00017406 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00006827 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00011924 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00011925 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Automated_description | Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in regulation of gene expression. Predicted to be located in nucleus. Used to study Alzheimer's disease. | Paper_evidence | WBPaper00065943 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:10652 | Homo sapiens | Paper_evidence | WBPaper00045043 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 Oct 2014 00:00:00 | ||||||||
| Disease_relevance | Human RE1-silencing transcription factor (REST), also known as Neuron-restrictive silencer factor (NRSF) is a transcriptional repressor, also involved in repression of neuronal genes during embryonic development that is down-regulated after terminal neuronal differentiation; recent transcriptional profiling data indicate that REST is induced in the aging brain and declines in Alzhemier''s disease (AD); REST is neuroprotective, repressing genes involved in cell death and strongly inhibiting tau phosphorylation, associated with AD; REST-deficient mice showed a progressive age-related neurodegenerative phenotype; in C. elegans, mutations in the multi-zinc finger transcripton factors, spr-3 and spr-4, structurally resembling mammalian REST, and a mutation in spr-1, orthologous to CoREST, showed significantly reduced survival relative to wild-type controls, with spr-4(by105) most affected; further, transgenic expression of human REST could functionally replace wild-type spr-4, as indicated by reducing paraquat-induced elevated ROS levels in spr-4(by105) and by repressing the presenilin gene hop-1, which is repressed by SPR-4; SPR-4 also modulated the neurotoxicity of A-beta in an C. elegans line that expresses A-beta42 in glutamatergic neurons and undergoes age-dependent neuronal loss, when this line was crossed with the spr-4(by105) mutant, the resulting line expressed A-beta42 and showed significantly accelerated neurodegeneration; thus, SPR-4 protects against both oxidative stress and A-beta toxicity, consistent with a general role in stress resistance. | Homo sapiens | Paper_evidence | WBPaper00045043 | |||||
| Accession_evidence | OMIM | 600571 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 22 Oct 2014 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000800 | ||||||||
| Molecular_info | Corresponding_CDS | C07A12.5a | |||||||
| C07A12.5b | |||||||||
| Corresponding_CDS_history | C07A12.5:wp81 | ||||||||
| C07A12.5:wp114 | |||||||||
| C07A12.5b:wp271 | |||||||||
| Corresponding_transcript | C07A12.5a.1 | ||||||||
| C07A12.5b.1 | |||||||||
| Associated_feature | WBsf648017 | ||||||||
| WBsf648018 | |||||||||
| WBsf1004973 | |||||||||
| WBsf1004974 | |||||||||
| WBsf1022801 | |||||||||
| WBsf1022802 | |||||||||
| WBsf235588 | |||||||||
| Transcription_factor | WBTranscriptionFactor000627 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00113378 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00114341 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00067551 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00000791 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00039964 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00010358 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2603 | ||||||||
| Expr2604 | |||||||||
| Expr2605 | |||||||||
| Expr9762 | |||||||||
| Expr9770 | |||||||||
| Expr1027050 | |||||||||
| Expr1032492 | |||||||||
| Expr1144043 | |||||||||
| Expr2016090 | |||||||||
| Expr2034325 | |||||||||
| Drives_construct | WBCnstr00010865 | ||||||||
| WBCnstr00014282 | |||||||||
| WBCnstr00014290 | |||||||||
| WBCnstr00035271 | |||||||||
| Construct_product | WBCnstr00035271 | ||||||||
| WBCnstr00038836 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (142) | |||||||||
| Interaction (18) | |||||||||
| Map_info | Map | X | Position | -7.38771 | Error | 0.016176 | |||
| Positive | Positive_clone | C07A12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4256 | |||||||
| 4692 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | published in Wen et al., PNAS 97: 14527-14529, 2000 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
