WormBase Tree Display for Gene: WBGene00005008
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| WBGene00005008 | Evidence | Paper_evidence | WBPaper00005903 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C07A12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | spr-3 | Person_evidence | WBPerson220 | |||||
| Sequence_name | C07A12.5 | ||||||||
| Molecular_name | C07A12.5a | ||||||||
| C07A12.5a.1 | |||||||||
| CE36266 | |||||||||
| C07A12.5b | |||||||||
| CE53297 | |||||||||
| C07A12.5b.1 | |||||||||
| Other_name | CELE_C07A12.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | spr-3 | ||||||||
| DB_info | Database | AceView | gene | XF135 | |||||
| WormQTL | gene | WBGene00005008 | |||||||
| WormFlux | gene | WBGene00005008 | |||||||
| OMIM | gene | 600571 | |||||||
| NDB | locus_tag | CELE_C07A12.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00005008|UniProtKB=Q17768 | |||||||
| family | PTHR24403 | ||||||||
| NCBI | gene | 180722 | |||||||
| RefSeq | protein | NM_001373281.4 | |||||||
| NM_001029196.5 | |||||||||
| SwissProt | UniProtAcc | Q17768 | |||||||
| UniProt_GCRP | UniProtAcc | Q17768 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info (10) | |||||||||
| Disease_info | Experimental_model | DOID:10652 | Homo sapiens | Paper_evidence | WBPaper00045043 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 Oct 2014 00:00:00 | ||||||||
| Disease_relevance | Human RE1-silencing transcription factor (REST), also known as Neuron-restrictive silencer factor (NRSF) is a transcriptional repressor, also involved in repression of neuronal genes during embryonic development that is down-regulated after terminal neuronal differentiation; recent transcriptional profiling data indicate that REST is induced in the aging brain and declines in Alzhemier''s disease (AD); REST is neuroprotective, repressing genes involved in cell death and strongly inhibiting tau phosphorylation, associated with AD; REST-deficient mice showed a progressive age-related neurodegenerative phenotype; in C. elegans, mutations in the multi-zinc finger transcripton factors, spr-3 and spr-4, structurally resembling mammalian REST, and a mutation in spr-1, orthologous to CoREST, showed significantly reduced survival relative to wild-type controls, with spr-4(by105) most affected; further, transgenic expression of human REST could functionally replace wild-type spr-4, as indicated by reducing paraquat-induced elevated ROS levels in spr-4(by105) and by repressing the presenilin gene hop-1, which is repressed by SPR-4; SPR-4 also modulated the neurotoxicity of A-beta in an C. elegans line that expresses A-beta42 in glutamatergic neurons and undergoes age-dependent neuronal loss, when this line was crossed with the spr-4(by105) mutant, the resulting line expressed A-beta42 and showed significantly accelerated neurodegeneration; thus, SPR-4 protects against both oxidative stress and A-beta toxicity, consistent with a general role in stress resistance. | Homo sapiens | Paper_evidence | WBPaper00045043 | |||||
| Accession_evidence | OMIM | 600571 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 22 Oct 2014 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000800 | ||||||||
| Molecular_info | Corresponding_CDS | C07A12.5a | |||||||
| C07A12.5b | |||||||||
| Corresponding_CDS_history | C07A12.5:wp81 | ||||||||
| C07A12.5:wp114 | |||||||||
| C07A12.5b:wp271 | |||||||||
| Corresponding_transcript | C07A12.5a.1 | ||||||||
| C07A12.5b.1 | |||||||||
| Associated_feature | WBsf648017 | ||||||||
| WBsf648018 | |||||||||
| WBsf1004973 | |||||||||
| WBsf1004974 | |||||||||
| WBsf1022801 | |||||||||
| WBsf1022802 | |||||||||
| WBsf235588 | |||||||||
| Transcription_factor | WBTranscriptionFactor000627 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00113378 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00114341 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00067551 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00000791 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00039964 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00010358 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2603 | ||||||||
| Expr2604 | |||||||||
| Expr2605 | |||||||||
| Expr9762 | |||||||||
| Expr9770 | |||||||||
| Expr1027050 | |||||||||
| Expr1032492 | |||||||||
| Expr1144043 | |||||||||
| Expr2016090 | |||||||||
| Expr2034325 | |||||||||
| Drives_construct | WBCnstr00010865 | ||||||||
| WBCnstr00014282 | |||||||||
| WBCnstr00014290 | |||||||||
| WBCnstr00035271 | |||||||||
| Construct_product | WBCnstr00035271 | ||||||||
| WBCnstr00038836 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (142) | |||||||||
| Interaction (18) | |||||||||
| Map_info | Map | X | Position | -7.38771 | Error | 0.016176 | |||
| Positive | Positive_clone | C07A12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4256 | |||||||
| 4692 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | published in Wen et al., PNAS 97: 14527-14529, 2000 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
