WormBase Tree Display for Gene: WBGene00004989

WBGene00004989 SMap: S_parent: Sequence: T08A9
  Identity: Version: 1
    Name: CGC_name: spp-4
      Sequence_name: T08A9.8
      Molecular_name: T08A9.8
        T08A9.8.1
        CE04923
      Other_name: CELE_T08A9.8 Accession_evidence: NDB BX284606
      Public_name: spp-4
    DB_info: Database: AceView gene XH938
        WormQTL gene WBGene00004989
        WormFlux gene WBGene00004989
        NDB locus_tag CELE_T08A9.8
        Panther gene CAEEL|WormBase=WBGene00004989|UniProtKB=Q22338
          family PTHR21579
        NCBI gene 188266
        RefSeq protein NM_076836.6
        TREEFAM TREEFAM_ID TF343148
        TrEMBL UniProtAcc Q22338
        UniProt_GCRP UniProtAcc Q22338
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:37 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: spp
    Allele (15)
    RNASeq_FPKM (74)
    Ortholog (19)
    Paralog (12)
    Structured_description: Concise_description: spp-4 encodes an antimicrobial peptide that belongs to the SPP-protein family, called caenopores, with structural similarity to saposin-like proteins (SAPLIPs), the amoebapores and the mammalian NK-lysin and granulysin; caenopores are part of the worm's innate immune system and interact with and eliminate bacteria via membrane pore-forming activity; C. elegans has at least 33 putative SPP proteins; phylogenetic analysis indicates that spp-4 is most similar to spp-2, spp-5 and spp-6. Paper_evidence: WBPaper00035289
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Sep 2013 00:00:00
      Automated_description: Enriched in hypodermis; intestine; male-specific anatomical entity; muscle cell; and neurons based on tiling array; RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including daf-16; daf-2; and dpy-10 based on microarray and RNA-seq studies. Is affected by twenty-four chemicals including Heme; methylmercuric chloride; and bisphenol S based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: Saposin B type, region 2; Saposin B type domain; Saposin-like; Phosphorylation site; and Saposin-like type B, region 2. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T08A9.8
    Corresponding_transcript: T08A9.8.1
    Other_sequence (89)
    Associated_feature: WBsf237570
  Experimental_info: RNAi_result: WBRNAi00075981 Inferred_automatically: RNAi_primary
      WBRNAi00082193 Inferred_automatically: RNAi_primary
      WBRNAi00018422 Inferred_automatically: RNAi_primary
      WBRNAi00052829 Inferred_automatically: RNAi_primary
      WBRNAi00035334 Inferred_automatically: RNAi_primary
      WBRNAi00082200 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1027235
      Expr1156431
      Expr2016082
      Expr2034318
    Drives_construct: WBCnstr00035288
    Construct_product: WBCnstr00035288
    Microarray_results (16)
    Expression_cluster (268)
    Interaction (47)
  Map_info: Map: X Position: -1.77366
    Positive: Positive_clone: T08A9 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00003435
    WBPaper00006437
    WBPaper00024209
    WBPaper00035289
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene