WormBase Tree Display for Gene: WBGene00004980
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| WBGene00004980 | SMap | S_parent | Sequence | B0464 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | spk-1 | Person_evidence | WBPerson1315 | |||||
| Sequence_name | B0464.5 | ||||||||
| Molecular_name (13) | |||||||||
| Other_name | srk-1 | ||||||||
| rsk-1 | Paper_evidence | WBPaper00003988 | |||||||
| CELE_B0464.5 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | spk-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spk | ||||||||
| Allele (80) | |||||||||
| Strain | WBStrain00035941 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (51) | |||||||||
| Paralog (21) | |||||||||
| Structured_description | Concise_description | spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600). | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00004476 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables protein serine/threonine kinase activity. Involved in embryo development. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including gonad and tail. Is an ortholog of human SRPK1 (SRSF protein kinase 1); SRPK2 (SRSF protein kinase 2); and SRPK3 (SRSF protein kinase 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | B0464.5a | |||||||
| B0464.5b | |||||||||
| B0464.5c | |||||||||
| B0464.5d | |||||||||
| Corresponding_CDS_history | B0464.5a:wp123 | ||||||||
| B0464.5c:wp119 | |||||||||
| Corresponding_transcript | B0464.5a.1 | ||||||||
| B0464.5a.2 | |||||||||
| B0464.5b.1 | |||||||||
| B0464.5c.1 | |||||||||
| B0464.5d.1 | |||||||||
| Other_sequence (83) | |||||||||
| Associated_feature (20) | |||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern | Chronogram621 | ||||||||
| Expr439 | |||||||||
| Expr1128 | |||||||||
| Expr5076 | |||||||||
| Expr1028333 | |||||||||
| Expr1032478 | |||||||||
| Expr1143250 | |||||||||
| Expr2016060 | |||||||||
| Expr2034296 | |||||||||
| Drives_construct | WBCnstr00004059 | ||||||||
| WBCnstr00035294 | |||||||||
| Construct_product | WBCnstr00035294 | ||||||||
| Microarray_results (50) | |||||||||
| Expression_cluster (119) | |||||||||
| Interaction (131) | |||||||||
| WBProcess | WBbiopr:00000014 | ||||||||
| Map_info | Map | III | Position | 0.536942 | Error | 0.008194 | |||
| Positive | Positive_clone | B0464 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| T01H8 | |||||||||
| Mapping_data | Multi_point | 5000 | |||||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | The srk-1 gene was merged into this gene following advice by Jonathan Hodgkin. srk-1 was connected to different sequences which may have been in error and these sequence connections have been removed from the merged gene. krb 27/02/02 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
