WormBase Tree Display for Gene: WBGene00004973

WBGene00004973 SMap: S_parent: Sequence: C06E7
  Identity: Version: 1
    Name: CGC_name: spe-27 Person_evidence: WBPerson252
      Sequence_name: C06E7.6
      Molecular_name: C06E7.6
        C06E7.6.1
        CE03962
      Other_name: CELE_C06E7.6 Accession_evidence: NDB BX284604
      Public_name: spe-27
    DB_info: Database: AceView gene 4G630
        WormQTL gene WBGene00004973
        WormFlux gene WBGene00004973
        NDB locus_tag CELE_C06E7.6
        Panther gene CAEEL|WormBase=WBGene00004973|UniProtKB=P54218
          family PTHR34493
        NCBI gene 177357
        RefSeq protein NM_068474.7
        SwissProt UniProtAcc P54218
        TREEFAM TREEFAM_ID TF343123
        UniProt_GCRP UniProtAcc P54218
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:37 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: spe
    Allele (16)
    Legacy_information: [C.elegansII] it132 : ts, hermaphrodites produce nonfunctionalsperm, males are fertile. Hypomorphic allele.OA>3: some alleles probably null. Cloned: transcript only in spermatogenic germ line, encodes novel predicted protein. [BA]
    Strain (11)
    RNASeq_FPKM (74)
    GO_annotation: 00048253
      00048254
      00048255
    Ortholog (15)
    Paralog: WBGene00189995 Caenorhabditis elegans From_analysis: Panther
      WBGene00011548 Caenorhabditis elegans From_analysis: Panther
      WBGene00013573 Caenorhabditis elegans From_analysis: Panther
      WBGene00044391 Caenorhabditis elegans From_analysis: Panther
      WBGene00044024 Caenorhabditis elegans From_analysis: Panther
      WBGene00011508 Caenorhabditis elegans From_analysis: Panther
      WBGene00020983 Caenorhabditis elegans From_analysis: Panther
      WBGene00015679 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: spe-27 encodes a novel, hydrophilic protein; spe-27 is required for hermaphrodite spermatogenesis or sperm activation but not for male-derived sperm activation (sperm activation is the morphogenesis of a round non-motile spermatid to an amoeboid crawling sperm); however, mutant hermaphrodite spe-27 spermatids can transactivate and form functional sperm during mating with males; genetic and phenotypic evidence suggests that spe-27 acts in a common pathway with spe-8, spe-12, spe-19 and spe-29. Paper_evidence: WBPaper00002446
            WBPaper00004444
          Curator_confirmed: WBPerson48
            WBPerson1843
            WBPerson324
          Date_last_updated: 26 Jul 2010 00:00:00
      Automated_description: Involved in spermatid development. Expressed in sperm; spermatocyte; and in male. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C06E7.6
    Corresponding_transcript: C06E7.6.1
  Experimental_info: RNAi_result: WBRNAi00039916 Inferred_automatically: RNAi_primary
      WBRNAi00010324 Inferred_automatically: RNAi_primary
      WBRNAi00027822 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1561
      Expr1562
      Expr1023781
      Expr1143995
      Expr2016037
      Expr2034271
    Drives_construct: WBCnstr00035298
    Construct_product: WBCnstr00035298
    Microarray_results (17)
    Expression_cluster: WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00040285:H2S_12hr_upregulated
      WBPaper00041071:spe-44_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044736:rising_dev_expression
      WBPaper00045420:fertilization_upregulated_transcript
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00046805:P-granule-RNAi_upregulated_Set1
      WBPaper00048762:FOG-3_associated
      WBPaper00049377:MWCNT_upregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00050231:male_enriched
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00054872:egl-9(sa307)_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055648:sperm_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059253:sucrose_downregulated
      WBPaper00059253:sucrose_stearic-acid_downregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061340:Tail_hypodermis
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061527:C01G10.14-dct-9_3227
      WBPaper00061651:RMF_enriched
      WBPaper00061753:csr-1(tor159)_downregulated_20C
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_transcript
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4489_group_18
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00026629:L2_male_enriched
      WBPaper00026629:L4_male_enriched
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00027111:rrf-2(ok210)_downregulated
      WBPaper00035504:daf-2(e1370)_upregulated
      WBPaper00036286:Pattern_E
      WBPaper00038172:aak-2overexpression_up_regulated
      WBPaper00042236:flcn-1(ok975)_upregulated
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045263:ProLongevity-mtROS_downregulated
      WBPaper00045673:colistin_downregulated
      WBPaper00051387:Triclosan_downregulated
      [cgc6390]:Cluster_D
      [cgc6390]:mixed_spermatogenesis-somatic
    Interaction (49)
    WBProcess: WBbiopr:00000069
  Map_info: Map: IV Position: 2.435 Error: 0.000957
    Well_ordered
    Positive: Positive_clone: C06E7 Inferred_automatically: From sequence, transcript, pseudogene data
        DC12
    Mapping_data: 2_point: 7049
        7050
      Multi_point: 4783
      Pos_neg_data: 8919
        8920
        8921
        8922
        9076
  Reference (44)
  Method: Gene