WormBase Tree Display for Gene: WBGene00004972

WBGene00004972 SMap: S_parent: Sequence: R10H10
  Identity: Version: 1
    Name: CGC_name: spe-26 Person_evidence: WBPerson252
      Sequence_name: R10H10.2
      Molecular_name: R10H10.2
        R10H10.2.1
        CE06293
      Other_name: CELE_R10H10.2 Accession_evidence: NDB BX284604
      Public_name: spe-26
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:37 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: spe
    Allele (33)
    Legacy_information: [C.elegansII] hc138 : accumulates defective spermatocytes; pleiotropic effects in increasing lifespan, thermotolerance, UV resistance. OA5: hc139, hc140, it112, it118, hc107ts( Spe, non-Age).5/6 alleles ts. Cloned: encodes 570 aa protein containing 5 tandem 50 aa scruin/kelch repeats, possible actin-binding domains. [Van Voorhies 1992; Varkey et al. 1995; BA; HU; KK]
      [Varkey JP] hc138 rescued by 6.5 kb HindIII fragment from C26H10. Predicted gene R10H10.2
    Strain (12)
    RNASeq_FPKM (74)
    GO_annotation: 00056371
      00056372
      00056373
      00056374
    Ortholog (31)
    Paralog (11)
    Structured_description: Concise_description: spe-26 encodes a Kelch motif-containing protein similar to the Drosophila proteins kelch and diablo and the Limulus (horseshoe crab) actin-bundling protein scruin; SPE-26 activity is required for several processes including embryogenesis, spermatogenesis, thermotolerance, and regulation of lifespan; SPE-26 mRNA is detected in spermatogonial cells and spermatocytes, but not in spermatids. Paper_evidence: WBPaper00002181
            WBPaper00004651
            WBPaper00020755
            WBPaper00021636
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable actin binding activity. Predicted to be located in cytoplasm and cytoskeleton. Expressed in spermatocyte and in male. Human ortholog(s) of this gene implicated in spermatogenic failure 11. Is an ortholog of human KLHL10 (kelch like family member 10). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070180 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18829)
  Molecular_info: Corresponding_CDS: R10H10.2
    Corresponding_transcript: R10H10.2.1
    Other_sequence: CJC18311_1
    Associated_feature: WBsf230728
  Experimental_info: RNAi_result (20)
    Expr_pattern: Expr1550
      Expr1028235
      Expr1032473
      Expr1155404
      Expr2016036
      Expr2034270
    Drives_construct: WBCnstr00035299
    Construct_product: WBCnstr00035299
    Microarray_results (18)
    Expression_cluster (152)
    Interaction: WBInteraction000000409
      WBInteraction000000776
      WBInteraction000001112
      WBInteraction000001396
      WBInteraction000001708
      WBInteraction000004789
      WBInteraction000004790
      WBInteraction000008426
      WBInteraction000008427
      WBInteraction000008428
      WBInteraction000008429
      WBInteraction000030290
      WBInteraction000031761
      WBInteraction000126062
      WBInteraction000126382
      WBInteraction000126973
      WBInteraction000133315
      WBInteraction000134525
      WBInteraction000141688
      WBInteraction000164883
      WBInteraction000166497
      WBInteraction000185240
      WBInteraction000185824
      WBInteraction000191516
      WBInteraction000204799
      WBInteraction000209783
      WBInteraction000210954
      WBInteraction000210957
      WBInteraction000218683
      WBInteraction000223000
      WBInteraction000228767
      WBInteraction000237751
      WBInteraction000239599
      WBInteraction000247390
      WBInteraction000253076
      WBInteraction000255736
      WBInteraction000263783
      WBInteraction000271028
      WBInteraction000271483
      WBInteraction000281496
      WBInteraction000281944
      WBInteraction000288130
      WBInteraction000289016
      WBInteraction000294450
      WBInteraction000303247
      WBInteraction000308085
      WBInteraction000312824
      WBInteraction000316595
      WBInteraction000316693
      WBInteraction000319014
      WBInteraction000325770
      WBInteraction000328770
      WBInteraction000333363
      WBInteraction000345107
      WBInteraction000345967
      WBInteraction000349791
      WBInteraction000354352
      WBInteraction000363744
      WBInteraction000378302
      WBInteraction000378707
      WBInteraction000395445
      WBInteraction000399270
      WBInteraction000402222
      WBInteraction000403346
      WBInteraction000403414
      WBInteraction000404897
      WBInteraction000405554
      WBInteraction000409738
      WBInteraction000414117
      WBInteraction000421753
      WBInteraction000426053
      WBInteraction000426170
      WBInteraction000426253
      WBInteraction000429189
      WBInteraction000430218
      WBInteraction000436811
      WBInteraction000442055
      WBInteraction000445436
      WBInteraction000472634
      WBInteraction000519006
    WBProcess: WBbiopr:00000069
  Map_info: Map: IV Position: 4.58041 Error: 0.001418
    Well_ordered
    Positive: Positive_clone: C26H10
        R10H10 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 7044
        7045
        7046
        7047
        7048
      Multi_point: 4373
        4660
      Pos_neg_data: 8905
        8906
        8907
  Reference (58)
  Remark: Extracted from Varkey et al. (1995)
  Method: Gene