WormBase Tree Display for Gene: WBGene00004953
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| WBGene00004953 | Evidence | Author_evidence | O'Connell KF | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F32H2 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | spd-2 | Person_evidence | WBPerson689 | |||||
| Sequence_name | F32H2.3 | ||||||||
| Molecular_name | F32H2.3 | ||||||||
| F32H2.3.1 | |||||||||
| CE09878 | |||||||||
| Other_name | CELE_F32H2.3 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | spd-2 | ||||||||
| DB_info | Database | AceView | gene | 1J544 | |||||
| WormQTL | gene | WBGene00004953 | |||||||
| WormFlux | gene | WBGene00004953 | |||||||
| NDB | locus_tag | CELE_F32H2.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004953|UniProtKB=P91870 | |||||||
| family | PTHR16029 | ||||||||
| NCBI | gene | 172712 | |||||||
| RefSeq | protein | NM_060013.8 | |||||||
| SwissProt | UniProtAcc | P91870 | |||||||
| UniProt_GCRP | UniProtAcc | P91870 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spd | ||||||||
| Allele (48) | |||||||||
| Legacy_information | [O'Connell KF] Spindle defective, temperature-sensitive sterile, uncoordinated | ||||||||
| Complementation_data | [O'Connell KF] complements fer-1(hc13), let-541(h886), let-536(h882) | ||||||||
| Strain | WBStrain00040367 | ||||||||
| WBStrain00007355 | |||||||||
| WBStrain00007382 | |||||||||
| WBStrain00007385 | |||||||||
| WBStrain00007287 | |||||||||
| WBStrain00007306 | |||||||||
| WBStrain00034761 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (38) | |||||||||
| Ortholog (23) | |||||||||
| Structured_description | Concise_description | spd-2 encodes a protein with three predicted coiled-coil domains; SPD-2 activity is essential for centrosome maturation and duplication, and hence for proper mitotic spindle assembly; in regulating the early steps of centrosome maturation, SPD-2 acts together with the coiled-coil protein SPD-5, the Aurora-A kinase AIR-1, and the cytoplasmic dynein DHC-1; in regulating centrosome duplication, SPD-2 likely acts together with the ZYG-1 kinase; in both processes, SPD-2 may function to recruit centrosomal components such as ZYG-9 and microtubule-nucleating gamma-tubulin complexes to the developing centrosome; within centrosomes, SPD-2 localizes to both centrioles and the pericentriolar material; efficient centrosomal localization depends upon AIR-1 and DHC-1, while localization specifically to the pericentriolar material depends upon SPD-5. | Paper_evidence | WBPaper00003120 | |||||
| WBPaper00004200 | |||||||||
| WBPaper00013411 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 07 Oct 2004 00:00:00 | ||||||||
| Automated_description | Enables protein kinase binding activity. Involved in several processes, including centriole replication; embryo development; and vulval development. Located in centriole; cytoplasm; and pericentriolar material. Expressed in intestinal cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F32H2.3 | |||||||
| Corresponding_transcript | F32H2.3.1 | ||||||||
| Other_sequence | CBC02720_1 | ||||||||
| CGC01264_1 | |||||||||
| CR08152 | |||||||||
| CRC00122_1 | |||||||||
| Associated_feature | WBsf649431 | ||||||||
| WBsf984548 | |||||||||
| WBsf220011 | |||||||||
| WBsf220012 | |||||||||
| Experimental_info | RNAi_result (54) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct (15) | |||||||||
| Construct_product (11) | |||||||||
| Antibody | WBAntibody00000747 | ||||||||
| WBAntibody00000822 | |||||||||
| WBAntibody00000889 | |||||||||
| WBAntibody00001163 | |||||||||
| WBAntibody00002268 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (156) | |||||||||
| Interaction (138) | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| Map_info | Map | I | Position | 3.3366 | Error | 0.001372 | |||
| Positive | Inside_rearr | nDf23 | |||||||
| nDf24 | |||||||||
| nDf25 | |||||||||
| Positive_clone | F32H2 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Negative | Outside_rearr | nDf29 | |||||||
| nDf30 | |||||||||
| dxDf1 | |||||||||
| Mapping_data | 2_point | 7098 | |||||||
| Multi_point | 3661 | ||||||||
| 3662 | |||||||||
| 3807 | |||||||||
| 4988 | |||||||||
| Pos_neg_data | 9377 | ||||||||
| 9378 | |||||||||
| 9379 | |||||||||
| 10241 | |||||||||
| 10242 | |||||||||
| 10554 | |||||||||
| Reference (78) | |||||||||
| Remark | Locus-Positive-Method is sequenced alleles/RNAi | Person_evidence | WBPerson728 | ||||||
| Method | Gene |
