WormBase Tree Display for Gene: WBGene00004857
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| WBGene00004857 | SMap | S_parent | Sequence | R13F6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sma-3 | Person_evidence | WBPerson261 | |||||
| Sequence_name | R13F6.9 | ||||||||
| Molecular_name | R13F6.9 | ||||||||
| R13F6.9.1 | |||||||||
| CE25974 | |||||||||
| Other_name | CELE_R13F6.9 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | sma-3 | ||||||||
| DB_info | Database | AceView | gene | 3H952 | |||||
| WormQTL | gene | WBGene00004857 | |||||||
| SignaLink | protein | WBGene00004857 | |||||||
| WormFlux | gene | WBGene00004857 | |||||||
| NDB | locus_tag | CELE_R13F6.9 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004857|UniProtKB=P45896 | |||||||
| family | PTHR13703 | ||||||||
| NCBI | gene | 175955 | |||||||
| RefSeq | protein | NM_066092.5 | |||||||
| SwissProt | UniProtAcc | P45896 | |||||||
| UniProt_GCRP | UniProtAcc | P45896 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sma | ||||||||
| Reference_allele | WBVar00143246 | ||||||||
| Allele (54) | |||||||||
| Legacy_information | e491 : short somewhat dumpy; males have crumpled spicules. ES3 (adult) ME0. NA3 (e637 e958). | ||||||||
| See also e491 | |||||||||
| [C.elegansII] e491 : short, somewhat dumpy; males have crumpled spicules, abnormal rays. Similar to Sma-2, Sma-4, Daf-4ES3 (adult), ME0. OA2: e637, e958. Cloned: encodes DWARFIN. [Baird et al. 1991; LT; PB] | |||||||||
| Strain (23) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (43) | |||||||||
| Ortholog (34) | |||||||||
| Paralog | WBGene00000899 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| WBGene00000904 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000910 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004856 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004858 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006445 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | sma-3 encodes a Smad protein; during development, SMA-3 functions as part of a DBL-1/SMA-6 TGF-beta-related signaling pathway that controls body size and male tail sensory ray and spicule formation; sma-3, through this pathway, also regulates reproductive aging; studies have shown that a reduction of TGF-beta pathway genes extends reproductive span by maintaining oocyte and germline quality; sma-3 is widely expressed at all developmental stages, beginning during embryogenesis, continuing through all larval stages, and seen very strongly in adult hermaphrodites and males; a SMA-3::GFP is detected in the pharynx, intestine, and hypodermis and localizes to the nucleus; sma-3 expression in the hypodermis is necessary and sufficient for normal body size; SMA-3 can physically interact with the LIN-31 forkhead transcription factor and with DAF-16. | Paper_evidence | WBPaper00004199 | |||||
| WBPaper00005567 | |||||||||
| WBPaper00026644 | |||||||||
| WBPaper00035556 | |||||||||
| WBPaper00037682 | |||||||||
| WBPaper00051279 | |||||||||
| Person_evidence | WBPerson50 | ||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jul 2017 00:00:00 | ||||||||
| Automated_description | Enables transcription coactivator activity. Involved in several processes, including defense response to other organism; male anatomical structure morphogenesis; and regulation of developmental process. Located in cytoplasm and nucleus. Expressed in several structures, including hypodermis; intestine; pharynx; somatic gonad; and tail. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | R13F6.9 | |||||||
| Corresponding_transcript | R13F6.9.1 | ||||||||
| Other_sequence (32) | |||||||||
| Associated_feature | WBsf978789 | ||||||||
| WBsf992887 | |||||||||
| WBsf992888 | |||||||||
| WBsf1015163 | |||||||||
| WBsf226875 | |||||||||
| Transcription_factor | WBTranscriptionFactor001049 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00009073 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00051929 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00097938 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00026120 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00081750 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00051928 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027662 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075973 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005965 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00097937 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct (16) | |||||||||
| Construct_product (21) | |||||||||
| Regulate_expr_cluster | WBPaper00062491:sma-3(wk30)_downregulated | ||||||||
| WBPaper00062491:sma-3(wk30)_upregulated | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (114) | |||||||||
| Interaction (92) | |||||||||
| WBProcess | WBbiopr:00000025 | ||||||||
| WBbiopr:00000039 | |||||||||
| Map_info | Map | III | Position | -0.9165 | Error | 0.001173 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | sDf127 | |||||||
| nDf16 | |||||||||
| Positive_clone | R13F6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point | 64 | |||||||
| 482 | |||||||||
| 6038 | |||||||||
| 6040 | |||||||||
| Multi_point (69) | |||||||||
| Pos_neg_data | 1613 | ||||||||
| 1614 | |||||||||
| 1615 | |||||||||
| 5139 | |||||||||
| 8675 | |||||||||
| 8765 | |||||||||
| 8815 | |||||||||
| Landmark_gene | |||||||||
| Reference (176) | |||||||||
| Picture | WBPicture0000013077 | ||||||||
| Method | Gene |
