WormBase Tree Display for Gene: WBGene00004804
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| WBGene00004804 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | skn-1 | Person_evidence | WBPerson498 | |||||
| Sequence_name | T19E7.2 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | sow-1 | Paper_evidence | WBPaper00049017 | ||||||
| xrep-3 | Paper_evidence | WBPaper00051108 | |||||||
| skinhead 1 | Paper_evidence | WBPaper00053562 | |||||||
| CELE_T19E7.2 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | skn-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 12 Jan 2016 14:12:59 | WBPerson2970 | Name_change | Other_name | sow-2 | ||||
| 3 | 16 May 2017 09:44:11 | WBPerson2970 | Name_change | Other_name | xrep-3 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | skn | ||||||||
| Allele (161) | |||||||||
| Legacy_information | [C.elegansII] zu67mat : maternal effect embryonic lethal, extra internal hypodermal cells, fails to produce pharynx and intestine; EMS adopts P2-like fate(MS more affected than E). OA>5: or12, or13 etc. Cloned: encodes predicted transcription factor. Antibody stains early nuclei, differential localization to EMS, not detectable beyond 12-cell stage. [Bowerman et al. 1992, 1993; EU; JJ] | ||||||||
| Strain (28) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (84) | |||||||||
| Contained_in_operon | CEOP4172 | ||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00020961 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | skn-1 encodes a bZip transcription factor orthologous to the mammalian Nrf (Nuclear factor-erythroid-related factor) transcription factors; during early embryogenesis, maternally provided SKN-1 is required for specification of the EMS blastomere, a mesendodermal precursor that gives rise to pharyngeal, muscle, and intestinal cells; later, during postembryonic development, SKN-1 functions in the p38 MAPK pathway to regulate the oxidative stress response and in parallel to DAF-16/FOXO in the DAF-2-mediated insulin/IGF-1-like signaling pathway to regulate adult lifespan; in vitro assays indicate that SKN-1 can be directly phosphorylated by the AKT-1, AKT-2, and SGK-1 kinases that lie downstream of DAF-2 in the insulin signaling pathway and in vivo experiments suggest that this phosphorylation is essential for regulation of SKN-1 nuclear accumulation and hence, transcriptional regulator activity; in the early embryo, SKN-1 is detected at highest levels in nuclei of the P1 blastomere and its descendants through the 8-cell stage of embryogenesis; later in embryogenesis, SKN-1 is observed in all hypodermal and intestinal nuclei, with reporter constructs indicating that intestinal expression begins as early as the 50-100-cell stage; in larvae and young adults, SKN-1::GFP reporters are expressed in the intestine and ASI neurons, with expression in intestinal nuclei enhanced under conditions of stress or reduced DAF-2 signaling. | Paper_evidence | WBPaper00001521 | |||||
| WBPaper00001785 | |||||||||
| WBPaper00006024 | |||||||||
| WBPaper00031617 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 19 Aug 2008 00:00:00 | ||||||||
| Automated_description | Enables Hsp70 protein binding activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including endoderm development; endoplasmic reticulum unfolded protein response; and positive regulation of macromolecule biosynthetic process. Located in endoplasmic reticulum; mitochondrion; and nucleus. Expressed in several structures, including germ line; head ganglion; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; liver disease (multiple); obesity; and pulmonary emphysema. Is an ortholog of several human genes including NFE2 (nuclear factor, erythroid 2); NFE2L1 (NFE2 like bZIP transcription factor 1); and NFE2L2 (NFE2 like bZIP transcription factor 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (11) | ||||||||
| Molecular_info | Corresponding_CDS | T19E7.2a | |||||||
| T19E7.2b | |||||||||
| T19E7.2c | |||||||||
| T19E7.2d | |||||||||
| Corresponding_transcript | T19E7.2a.1 | ||||||||
| T19E7.2b.1 | |||||||||
| T19E7.2c.1 | |||||||||
| T19E7.2d.1 | |||||||||
| Other_sequence (45) | |||||||||
| Associated_feature (21) | |||||||||
| Gene_product_binds (3762) | |||||||||
| Transcription_factor | WBTranscriptionFactor000014 | ||||||||
| Experimental_info (11) | |||||||||
| Map_info | Map | IV | Position | 2.04386 | Error | 0.029993 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | B0547 | |||||||
| T19E7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 1708 | |||||||
| 1709 | |||||||||
| 4783 | |||||||||
| Pos_neg_data | 9033 | ||||||||
| 9038 | |||||||||
| Reference (864) | |||||||||
| Picture | WBPicture0000013046 | ||||||||
| WBPicture0000013093 | |||||||||
| Method | Gene |
