WormBase Tree Display for Gene: WBGene00004795

WBGene00004795 SMap: S_parent: Sequence: C04F5
  Identity: Version: 2
    Name: CGC_name: sid-1 Person_evidence: WBPerson278
      Sequence_name: C04F5.1
      Molecular_name: C04F5.1
        C04F5.1.1
        CE30331
      Other_name: rsd-8 Person_evidence: WBPerson1521
            WBPerson1463
            WBPerson2581
          Author_evidence: Plasterk RHA
        rde-7 Paper_evidence: WBPaper00036036
        CELE_C04F5.1 Accession_evidence: NDB BX284605
      Public_name: sid-1
    DB_info: Database: AceView gene 5F603
        WormQTL gene WBGene00004795
        WormFlux gene WBGene00004795
        NDB locus_tag CELE_C04F5.1
        Panther gene CAEEL|WormBase=WBGene00004795|UniProtKB=Q9GZC8
          family PTHR12185
        NCBI gene 178900
        RefSeq protein NM_071971.10
        SwissProt UniProtAcc Q9GZC8
        TREEFAM TREEFAM_ID TF313076
        UniProt_GCRP UniProtAcc Q9GZC8
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 16 Oct 2013 10:10:50 WBPerson2970 Name_change: Other_name: rde-7
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sid
    Allele (206)
    Strain (13)
    In_cluster: conserved_miRNA_siRNA_cluster
    RNASeq_FPKM (74)
    GO_annotation (23)
    Ortholog (24)
    Paralog: WBGene00012573 Caenorhabditis elegans From_analysis: TreeFam
            Panther
      WBGene00006477 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00015583 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00018205 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00016253 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: sid-1 encodes a dsRNA channel with conserved human (OMIM:606816) and mouse homologs; SID-1 functions to enable passive (ATP-independent) uptake of double-stranded RNA (dsRNA) and is required cell autonomously for systemic RNA interference (RNAi) and for efficient reduction of multicopy transgene expression (repeat-induced silencing); SID-1 is not, however, required for export of RNA silencing from C. elegans tissues; a SID-1::GFP fusion is enriched at cellular membranes of most nonneuronal cells from late embryogenesis through adulthood with highest levels detected in cells exposed to the environment; SID-1 extracellular domain (ECD) selectively binds long double-stranded RNA (dsRNA) and the binding affinity is related to RNA transport efficiency. Paper_evidence: WBPaper00005171
            WBPaper00006046
            WBPaper00032513
            WBPaper00046955
          Person_evidence: WBPerson30282
          Curator_confirmed: WBPerson1843
            WBPerson324
          Date_last_updated: 09 Dec 2015 00:00:00
      Automated_description: Enables RNA transmembrane transporter activity and double-stranded RNA binding activity. Involved in dsRNA transport and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in plasma membrane. Expressed in several structures, including pharynx. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C04F5.1
    Corresponding_transcript: C04F5.1.1
    Other_sequence: CRC01416_1
      Tcol_isotig15794
      CJC06957_1
      MAC02131_1
    Associated_feature: WBsf1019590
      WBsf231727
  Experimental_info: RNAi_result: WBRNAi00076077 Inferred_automatically: RNAi_primary
      WBRNAi00039639 Inferred_automatically: RNAi_primary
      WBRNAi00085060 Inferred_automatically: RNAi_primary
      WBRNAi00000928 Inferred_automatically: RNAi_primary
      WBRNAi00010132 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1867
      Expr11213
      Expr13321
      Expr1023218
      Expr1032379
      Expr1143735
      Expr2015814
      Expr2034047
    Drives_construct: WBCnstr00010496
      WBCnstr00018224
      WBCnstr00035384
    Construct_product (21)
    Regulate_expr_cluster: WBPaper00064375:sid-1(pk3321)_regulated
    Microarray_results (19)
    Expression_cluster (131)
    Interaction (29)
    Anatomy_function: WBbtf0731
  Map_info: Map: V Position: -2.49497 Error: 0.00506
    Positive: Positive_clone: C04F5 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5629
    Pseudo_map_position
  Reference: WBPaper00005171
    WBPaper00006046
    WBPaper00006075
    WBPaper00006232
    WBPaper00006323
    WBPaper00006362
    WBPaper00006382
    WBPaper00010021
    WBPaper00010292
    WBPaper00010629
    WBPaper00013376
    WBPaper00016768
    WBPaper00018870
    WBPaper00018895
    WBPaper00019033
    WBPaper00019494
    WBPaper00019497
    WBPaper00019501
    WBPaper00024419
    WBPaper00024434
    WBPaper00024516
    WBPaper00025129
    WBPaper00026007
    WBPaper00026570
    WBPaper00026973
    WBPaper00027054
    WBPaper00028800
    WBPaper00029290
    WBPaper00030545
    WBPaper00030549
    WBPaper00030758
    WBPaper00031436
    WBPaper00031484
    WBPaper00031898
    WBPaper00032049
    WBPaper00032513
    WBPaper00033742
    WBPaper00034569
    WBPaper00034579
    WBPaper00035245
    WBPaper00036337
    WBPaper00037401
    WBPaper00037412
    WBPaper00037544
    WBPaper00037550
    WBPaper00037555
    WBPaper00037587
    WBPaper00038303
    WBPaper00038491
    WBPaper00038725
    WBPaper00038898
    WBPaper00039192
    WBPaper00039766
    WBPaper00040575
    WBPaper00040725
    WBPaper00040950
    WBPaper00041217
    WBPaper00041563
    WBPaper00041679
    WBPaper00043399
    WBPaper00043610
    WBPaper00043989
    WBPaper00045285
    WBPaper00046081
    WBPaper00046416
    WBPaper00046955
    WBPaper00047221
    WBPaper00047430
    WBPaper00051563
    WBPaper00052435
    WBPaper00052462
    WBPaper00052470
    WBPaper00052479
    WBPaper00053173
    WBPaper00055090
    WBPaper00056400
    WBPaper00056988
    WBPaper00057161
    WBPaper00057162
    WBPaper00058055
    WBPaper00058174
    WBPaper00058186
    WBPaper00058443
    WBPaper00058471
    WBPaper00058720
    WBPaper00060343
    WBPaper00060459
    WBPaper00060622
    WBPaper00060750
    WBPaper00061061
    WBPaper00061115
    WBPaper00061409
    WBPaper00061562
    WBPaper00061750
    WBPaper00061805
    WBPaper00061894
    WBPaper00062345
    WBPaper00062465
    WBPaper00062676
    WBPaper00062691
    WBPaper00063036
    WBPaper00063405
    WBPaper00064204
    WBPaper00064375
    WBPaper00064403
    WBPaper00064523
    WBPaper00064634
    WBPaper00064639
    WBPaper00064987
    WBPaper00065265
    WBPaper00065275
    WBPaper00065312
    WBPaper00065560
    WBPaper00066313
  Remark: Sequence connection from [Winston W, Hunter C]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene