WormBase Tree Display for Gene: WBGene00004788
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| WBGene00004788 | SMap | S_parent | Sequence | C54H2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sft-4 | Person_evidence | WBPerson699 | |||||
| Sequence_name | C54H2.5 | ||||||||
| Molecular_name | C54H2.5 | ||||||||
| C54H2.5.1 | |||||||||
| CE06987 | |||||||||
| Other_name | SURF-4 | Accession_evidence | EMBL | Y14949 | |||||
| CELE_C54H2.5 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | sft-4 | ||||||||
| DB_info | Database | AceView | gene | XG398 | |||||
| WormQTL | gene | WBGene00004788 | |||||||
| WormFlux | gene | WBGene00004788 | |||||||
| NDB | locus_tag | CELE_C54H2.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004788|UniProtKB=Q18864 | |||||||
| family | PTHR23427 | ||||||||
| NCBI | gene | 180843 | |||||||
| RefSeq | protein | NM_076569.12 | |||||||
| SwissProt | UniProtAcc | Q18864 | |||||||
| TREEFAM | TREEFAM_ID | TF300001 | |||||||
| UniProt_GCRP | UniProtAcc | Q18864 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sft | ||||||||
| Allele (39) | |||||||||
| Strain | WBStrain00001112 | ||||||||
| WBStrain00001113 | |||||||||
| WBStrain00036029 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00004787 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00011379 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | sft-4 encodes an integral membrane protein orthologous to Saccharomyces cerevisiae endoplasmic reticulum (ER)-to-Golgi cargo receptor Erv29p and mouse Surfeit-4 (Surf-4); by homology, SFT-4 is predicted to function as a cargo receptor that selectively transports proteins in COPII vesicles from the ER to the cis-Golgi; SFT-4 activity is required for larval development and for normal down regulation of the LET-23 EGF receptor in the secondary vulval cell lineages; an SFT-4::GFP reporter fusion localizes to the perinuclear region of the cytoplasm, consistent with localization to the endoplasmic reticulum. | Paper_evidence | WBPaper00013574 | |||||
| WBPaper00045219 | |||||||||
| WBPaper00025129 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 19 Aug 2014 00:00:00 | ||||||||
| Automated_description | Enables cargo receptor activity. Involved in several processes, including negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of vulval development; and protein exit from endoplasmic reticulum. Located in endoplasmic reticulum exit site and perinuclear region of cytoplasm. Expressed in several structures, including head; hermaphrodite gonad; pharyngeal muscle cell; tail; and vulval precursor cell. Is an ortholog of human SURF4 (surfeit 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C54H2.5 | |||||||
| Corresponding_transcript | C54H2.5.1 | ||||||||
| Other_sequence (50) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (35) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00002026 | ||||||||
| WBCnstr00002027 | |||||||||
| WBCnstr00011292 | |||||||||
| WBCnstr00019384 | |||||||||
| WBCnstr00035388 | |||||||||
| WBCnstr00039895 | |||||||||
| Construct_product | WBCnstr00006217 | ||||||||
| WBCnstr00006224 | |||||||||
| WBCnstr00019384 | |||||||||
| WBCnstr00035388 | |||||||||
| WBCnstr00039895 | |||||||||
| Antibody | WBAntibody00002803 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (144) | |||||||||
| Interaction (111) | |||||||||
| Map_info | Map | X | Position | -4.34017 | Error | 0.013244 | |||
| Positive | Positive_clone | C54H2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
