WormBase Tree Display for Gene: WBGene00004773
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WBGene00004773 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | sem-4 | Person_evidence | WBPerson268 | |||||
Sequence_name | F15C11.1 | ||||||||
Molecular_name | F15C11.1 | ||||||||
F15C11.1.1 | |||||||||
CE17673 | |||||||||
Other_name | CELE_F15C11.1 | Accession_evidence | NDB | BX284601 | |||||
Public_name | sem-4 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | sem | ||||||||
Allele (118) | |||||||||
Legacy_information | [C.elegansII] n1378 : Egl, hermaphrodite sex muscles fail to differentiate; additional axon and lineage defects. ME0 (severe Mab), HME3. OA3: h769, n2087, n1971 (stronger allele, two mesodermal and six neuronal cell types pleiotropically affected; 2 additional touch cells formed in tail), etc. Cloned: encodes predicted protein with 6 C2H2 zincfinger motifs. [Desai et al. 1988; Mitani et al. 1993; MT; NH; TU] | ||||||||
Strain (13) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (25) | |||||||||
Ortholog (50) | |||||||||
Paralog | WBGene00017430 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
Structured_description | Concise_description | sem-4 encodes a zinc-finger protein; sem-4 activity is required for proper development of cells in neuronal, mesodermal, and vulval cell lineages; sem-4 activity is also required for transdifferentiation of the Y rectal cell to the PDA neuron during larval development; a SEM-4::GFP reporter fusions are widely expressed with fluorescence seen in a number of different cell types including neurons, hypodermis, vulval precursor cells, and tail blast cells such as B and F. | Paper_evidence | WBPaper00002518 | |||||
WBPaper00004300 | |||||||||
WBPaper00040964 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 04 Dec 2012 00:00:00 | ||||||||
Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell differentiation; regulation of transcription by RNA polymerase II; and response to oxidative stress. Located in nucleus. Expressed in several structures, including HSN; M lineage cell; rectal epithelial cell; rectum; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Duane retraction syndrome; Duane-radial ray syndrome; and Holt-Oram syndrome. Is an ortholog of human SALL1 (spalt like transcription factor 1) and SALL3 (spalt like transcription factor 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model (13) | ||||||||
Molecular_info | Corresponding_CDS | F15C11.1 | |||||||
Corresponding_transcript | F15C11.1.1 | ||||||||
Other_sequence (20) | |||||||||
Associated_feature (28) | |||||||||
Gene_product_binds (380) | |||||||||
Transcription_factor | WBTranscriptionFactor000098 | ||||||||
Experimental_info (8) | |||||||||
Map_info | Map | I | Position | 1.65489 | Error | 0.003417 | |||
Well_ordered | |||||||||
Positive | Positive_clone | E02H2 | |||||||
F15C11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 1446 | |||||||
1447 | |||||||||
2089 | |||||||||
4030 | |||||||||
5026 | |||||||||
5509 | |||||||||
Pos_neg_data (5) | |||||||||
Reference (87) | |||||||||
Method | Gene |