WormBase Tree Display for Gene: WBGene00004750

WBGene00004750 SMap: S_parent: Sequence: F19B10
  Identity: Version: 2
    Name: CGC_name: sea-1 Person_evidence: WBPerson421
      Sequence_name: F19B10.9
      Molecular_name: F19B10.9
        F19B10.9.1
        CE09476
      Other_name: tbx-18 Paper_evidence: WBPaper00026779
        Ce-tbx-18 Paper_evidence: WBPaper00002863
        CELE_F19B10.9 Accession_evidence: NDB BX284602
      Public_name: sea-1
    DB_info: Database: AceView gene 2D962
        WormQTL gene WBGene00004750
        WormFlux gene WBGene00004750
        NDB locus_tag CELE_F19B10.9
        Panther gene CAEEL|WormBase=WBGene00004750|UniProtKB=O02073
          family PTHR11267
        NCBI gene 173710
        RefSeq protein NM_062210.6
        SwissProt UniProtAcc O02073
        UniProt_GCRP UniProtAcc O02073
        OMIM gene 300307
            601719
            602427
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 19 Dec 2005 15:07:23 WBPerson2970 Event: Acquires_merge: WBGene00006548
              Name_change: Sequence_name: F19B10.9
                Other_name: tbx-18
      Acquires_merge: WBGene00006548
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sea
    Allele (111)
    Legacy_information: mutation isolated as a suppressor of X signal elements, genetically appears to be an autosomal signal element Person_evidence: WBPerson495
    Strain: WBStrain00035145
      WBStrain00036678
      WBStrain00036794
    RNASeq_FPKM (74)
    GO_annotation (24)
    Ortholog (69)
    Paralog (20)
    Structured_description: Concise_description: sea-1 encodes a T-box transcription factor; during development, sea-1 functions, zygotically and in a dose-dependent manner, as an autosomal element of the X:A (X chromosome:autosome) ratio that determines C. elegans sex; in opposition to the X signal elements, SEA-1 positively regulates transcription of xol-1, the master sex-determination switch gene that is essential for male development and for setting the proper activity level of the dosage compensation complex; consistent with its role as a regulator of sex determination, SEA-1 is expressed in nuclei of early embryos from approximately the 20- to 100-cell stage of embryogenesis. Paper_evidence: WBPaper00026779
          Curator_confirmed: WBPerson1843
          Date_last_updated: 23 Oct 2007 00:00:00
      Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in dosage compensation by hypoactivation of X chromosome; positive regulation of transcription by RNA polymerase II; and sex determination. Located in nucleus. Expressed in several structures, including coelomocyte; head muscle; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in Abruzzo-Erickson syndrome; X-linked cleft palate with or without ankyloglossia; and bone disease (multiple). Is an ortholog of several human genes including TBX15 (T-box transcription factor 15); TBX4 (T-box transcription factor 4); and TBX6 (T-box transcription factor 6). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111382 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11603)
      DOID:381 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11603)
      DOID:0111826 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11600)
      DOID:0112363 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11605)
      DOID:674 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11600)
      DOID:0060613 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11600)
  Molecular_info: Corresponding_CDS: F19B10.9
    Corresponding_transcript: F19B10.9.1
    Associated_feature: WBsf978787
      WBsf987333
      WBsf987334
      WBsf222873
    Transcription_factor: WBTranscriptionFactor000201
  Experimental_info: RNAi_result: WBRNAi00000778 Inferred_automatically: RNAi_primary
      WBRNAi00044987 Inferred_automatically: RNAi_primary
      WBRNAi00031117 Inferred_automatically: RNAi_primary
      WBRNAi00013541 Inferred_automatically: RNAi_primary
      WBRNAi00062211 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3766
      Expr4413
      Expr7511
      Expr10434
      Expr1015627
      Expr1032347
      Expr1148957
      Expr1200017
      Expr2015703
      Expr2033935
    Drives_construct: WBCnstr00005109
      WBCnstr00012656
      WBCnstr00015326
      WBCnstr00035412
    Construct_product: WBCnstr00005109
      WBCnstr00016689
      WBCnstr00035412
    Antibody: WBAntibody00000877
    Microarray_results (20)
    Expression_cluster (173)
    Interaction (76)
    WBProcess: WBbiopr:00000056
  Map_info: Map: II Position: -6.23142 Error: 0.000768
    Positive: Positive_clone: F19B10 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5672
    Pseudo_map_position
  Reference (17)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene